penem antibiotic
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2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Hunter R. Batchelder ◽  
Elizabeth Story-Roller ◽  
Evan P. Lloyd ◽  
Amit Kaushik ◽  
Kristina M. Bigelow ◽  
...  

Abstractβ-lactams are the most widely used antibiotic class to treat bacterial infections in humans. Mycobacteroides abscessus is an emerging pulmonary pathogen resistant to most antibiotics, including penicillins and cephalosporins. With no current FDA-approved treatment and cure rates <50%, there is a pressing need for effective therapies. Here we report T405, a new β-lactam of the penem subclass that exhibits potent activity against M. abscessus and a panel of drug-resistant strains isolated from cystic fibrosis patients. Additionally, in combination with the β-lactamase inhibitor avibactam, the rate of spontaneous resistance of M. abscessus to T405 approached the limit of detection. Lastly, we show the favorable pharmacokinetic profile of T405 in mice and the absence of toxicity at elevated dosage, which support the clinical potential of this compound.


ChemInform ◽  
2010 ◽  
Vol 26 (31) ◽  
pp. no-no
Author(s):  
M. ALTAMURA ◽  
E. PERROTTA ◽  
P. SBRACI ◽  
V. PESTELLINI ◽  
F. ARCAMONE ◽  
...  

Chemotherapy ◽  
2002 ◽  
Vol 48 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Lucio Ferrari ◽  
Maria Altamura ◽  
Massimo De Luca ◽  
Tomaso Ceruti

ChemInform ◽  
2001 ◽  
Vol 32 (10) ◽  
pp. no-no
Author(s):  
Federico Maria Arcamone ◽  
Maria Altamura ◽  
Enzo Perrotta ◽  
Attilio Crea ◽  
Stefano Manzini ◽  
...  

2000 ◽  
Vol 53 (10) ◽  
pp. 1086-1095 ◽  
Author(s):  
FEDERICO MARIA ARCAMONE ◽  
MARIA AURAMURA ◽  
ENZO PERROTTA ◽  
ATTILIO CREA ◽  
STEFANO MANZINI ◽  
...  

Chemotherapy ◽  
1999 ◽  
Vol 45 (6) ◽  
pp. 405-410 ◽  
Author(s):  
Fabio Varotto ◽  
Elena Parravidini ◽  
Massimo De Luca ◽  
Alessandro Casini ◽  
Franco Fraschini

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