Simplifying Dialysis Through User-Centered Design and Sensor-Based Interactions on the Tablo Hemodialysis System

Hemodialysis is a complicated process that comes with many risks to both the user and the patient. The Tablo Hemodialysis System demonstrates how applying user-centered approaches to design could greatly improve device usability, and in turn, user and patient safety. Even with the Covid-19 pandemic creating unexpected hurdles to this approach, Tablo’s sensor-based technology offers a unique solution to ensure that user needs continue to be met.

Severe methanol poisoning treated with a novel hemodialysis system: a case report, analysis, and review

In May and June 2020, an outbreak of methanol poisoning arose in the southwest United States linked to ingestion of contaminated hand sanitizer imported during the coronavirus disease 2019 pandemic, ultimately resulting in over a dozen hospitalizations and at least four deaths in New Mexico and Arizona. In this report, we describe one of these cases in which profound methanol intoxication was successfully treated with the Tablo® Hemodialysis System, the first reported case of toxic alcohol poisoning treated with this novel device. We carry out a formal regression analysis of the serial methanol levels obtained in this case to conservatively estimate that intermittent hemodialysis with Tablo achieved a clearance of methanol of 239 mL/min (95% confidence interval, 173–305 mL/min), a clearance that is well within the previously published standard of care. We conclude by reviewing both the treatment of toxic alcohol poisoning and the determinants of small molecule clearance with hemodialysis, emphasizing the importance of optimizing the dialytic treatment of intoxications with extended treatment times and the use of high-efficiency dialyzers.