Synthesis, Characterization, Antimicrobial, DNA Cleavage and Fluorescent Activity of Metal ion(II) Coordinate with 2H-Chromene Azo novel ligand

A new ligand 2H-chromene containing azo group 2-(4-nitrophenyl)-N-(4-(phenyldiazenyl)-2H-chromen-4-amine (AH), were synthesized from the condensation reaction (1:2)of 2'-hydroxychalcone and p-aminoazobenzene. Co(II), Cu(II) and Ni(II) complexes of the new ligand have been synthesized and characterized using C.H.N. analysis,1HNMR spectra, FT.IR, UV/Visible, magnetic susceptible, conductance measuring, and fluorescence spectral spectroscopy; 13CNMR spectroscopy of the ligand was also studied. Spectroscopic results revealed the 2H-Chromene Azo (AH) ligand behaves as monodentate chelating via the nitrogen atom of amine groupat position 4 having 1:1 [M:L] ratio; suggested that the cobalt and nickel complexes have the tetrahedralstructure and a distorted tetrahedralgeometry for the copper complex, indicating their non-electrolyte nature. The new ligand shows a fluorescence emissioncomparingwith this fluorescence quenching was noticed in its metal complexes. The antibacterial potency of the free ligand and its chelates with metal ion(II) were screened against E.coli, K.pneumoniae, Staph.aureus andB.Subtilis;The DNA cleavage activity of the free ligand and its 2H-chromene azo metal (II) complexes was performedby the gel electrophoresis process, which giventhat thesecompounds are effectiveupon DNA cleavage .

Formation of the rehabilitation therapy in patients with chronic pulmonary diseases by means of composite homeopathic remedies

According to the survey of 214 patients aged between 28 to 75 years (the average age 49 years) with chronic broncho-pulmonary diseases the author identified the informative of the use of medical test of the electro-acupunctural method by Reinhold Voll (EAV) when forming the rehabilitation therapy by using composite homeopathic remedies. The method presented in this study shows the dynamics of the electro-dermal skin conductance measuring at acupoints when choosing a composite homeopathic remedy. When testing homeopathic remedies and in case of compliance of the particular drug with physiological processes or biological information of the patient´s body the resonant response on a EAV device scale is being fixed as a positive medical test. At the same time the pathological changes in electrophysiological measurements such as the «maximum deflection» (MD) and the «range of return arrow» (RRA) return to relative range of physiological norm. In the study we introduce the research on objectification of the selection of homeopathic remedies and optimization of the recommended amount of complex homeopathic remedies in the patients with respiratory system diseases. The diagnostic results of the electro-acupunctural method by Reinhold Voll obtained in this study allow to forming tactics of the therapy using composite homeopathic remedies in the rehabilitation treatment of patients with chronic lung disease.

DETERMINATION OF THE UNIT OF CAPACITANCE

As part of the program to establish a wholly self-consistent group of basic electrical units for the country, the unit of capacitance maintained in the National Research Council has been determined in an absolute sense in terms of the frequency and resistance units maintained in the laboratories, with an accuracy comparable to that of the primary standards. The determination was made by connecting additional components to an existing capacitance and conductance measuring bridge to form a modified Wien bridge network. The results obtained indicate an accuracy of ± 0.0025%.