Niebieski ptak und cukier biały – Eine Klassifikation und Korpusanalyse der Funktion und Wortfolge polnischer Farbadjektive

SummaryThis paper investigates the position of Polish color adjectives in their attributive function in the noun phrase. In general, Polish attributive adjectives may precede the noun (AN) or follow it (NA). There is rich literature on this issue, especially on the motivation for AN or NA order in particular semantic classes of adjectives or types of adjective-noun constructions. However, most of the contributions are theoretical in nature and account for only a part of linguistic reality but fail to capture the entire scope of data. One of the reasons for this might be that, so far, no systematic empirical analysis of this specific syntactical phenomenon has been conducted. This paper presents the results from a corpus analysis (NKJP) of 203 noun-with-color-adjective constructions and their AN/NA distributions. These constructions were classified based on the color adjective’s function (qualifying, classificatory, or part of an idiom). The results show that, regardless of its respective function, Polish color adjectives typically tend to appear in the AN order.

BHi-Cect: a top-down algorithm for identifying the multi-scale hierarchical structure of chromosomes

High-throughput chromosome conformation capture (Hi-C) technology enables the investigation of genome-wide interactions among chromosome loci. Current algorithms focus on topologically associating domains (TADs), that are contiguous clusters along the genome coordinate, to describe the hierarchical structure of chromosomes. However, high resolution Hi-C displays a variety of interaction patterns beyond what current TAD detection methods can capture. Here, we present BHi-Cect, a novel top-down algorithm that finds clusters by considering every locus with no assumption of genomic contiguity using spectral clustering. Our results reveal that the hierarchical structure of chromosome is organized as ‘enclaves’, which are complex interwoven clusters at both local and global scales. We show that the nesting of local clusters within global clusters characterizing enclaves, is associated with the epigenomic activity found on the underlying DNA. Furthermore, we show that the hierarchical nesting that links different enclaves integrates their respective function. BHi-Cect provides means to uncover the general principles guiding chromatin architecture.

Degree of Grammaticalisation of Behind, Beneath, Between and Betwixt in Middle English

The present paper traces the history of four selected adverbs with the prefix be- in Middle English. Already in Old English behind, beneath, between and betwixt are attested to function as both adverbs and prepositions, which demonstrates that the process of grammaticalisation accounting for the development of prepositions from adverbs started before that period. The focus of the study are the diachronic changes of the degree of grammaticalisation of the examined lexemes in the Middle English period as demonstrated by the ratio of their use with a respective function in the most natural context. Hence, specially selected Middle English prose texts are analysed. The analysis shows that while behind and beneath are still frequently used as adverbs in the whole Middle English period, between and betwixt are predominantly used as prepositions already in Early Middle English. This clearly demonstrates that the degree of grammaticalisation of the latter two Middle English words was much higher than that of behind and beneath.

Influence of orchiectomy of seven month old bulls on bronchoalveolar immune function

ABSTRACT The present study evaluated the impact that orchiectomy, a routine but painful intervention in bovine husbandry, can cause on pulmonary immunity. To identify whether orchiectomy can impair lung defense, analyses of serum cortisol concentration and of alveolar macrophage and their function (phagocytosis and respiratory burst) were evaluated. Sixteen Holstein bulls (7 mo old, 250±50kg of body weight BW) were divided in two homogeneous groups - the castrated group and the sham group - and the sample were collected on Days -7, 1 and 7 relative to the day of the procedure. Serum cortisol concentration statistically increased on Days 1 and 7 (D-7: 4,97±1,28ng/ml; D1: 6,35 ±1,10ng/ml; D7: 8,28±1,94ng/ml) after castration and these variables seem to impact the alveolar macrophage percentage on D1 (D-7: 76,86±3,44%; D1: 60,92±2,44%; D7: 74,17±2,56%) and their respective function of phagocytosis (P) and the oxidative burst (OB) on Days 1 and 7 for the castrated group (P D-7: 56,25±15,63 arbitrary values; D1: 54,75±14,07 arbitrary values; D7: 31,77±8,44 arbitrary values; and OB D-7: 222,34±39,52 arbitrary values; D1: 135,25±37,68 arbitrary values; D7: 117,73±18,17 arbitrary values). These results indicate that surgical castration affected lung defense until seven days after the practice, so the pulmonary cell function was impaired for a period higher than that reported in the literature.

Person and Knowledge: Introduction

The relation between person and epistemicity has been a topic of investigation throughout the humanities, including linguistics, but has mostly been focused on how conceptualisations of these two notions overlap, or diverge. This paper reviews some of these conceptualisations, but also adds a finergrained picture of how they intersect in the world’s languages. Purported categories such as egophoric marking and lesser known expressions such as non-selected arguments (i.e. "ethical datives") are compared to evidentials and modals from a synchronic and diachronic perspective in order to explain how the roles of the speech-act participants as specific arguments relate to their respective function as epistemic authorities. The aim of the paper is to introduce separate contributions relating to such systems as they are found in various parts of the world.

Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity

Most kallikrein-related peptidases (KLKs) are N-glycosylated with N-acetylglucosamine2-mannose9 units at Asn-Xaa-Ser/Thr sequons during protein synthesis and translocation into the endoplasmic reticulum. These N-glycans are modified in the Golgi machinery, where additional O-glycosylation at Ser and Thr takes place, before exocytotic release of the KLKs into the extracellular space. Sequons are present in all 15 members of the KLKs and comparative studies for KLKs from natural and recombinant sources elucidated some aspects of glycosylation. Although glycosylation of mammalian KLKs 1, 3, 4, 6, and 8 has been analyzed in great detail, e.g., by crystal structures, the respective function remains largely unclear. In some cases, altered enzymatic activity was observed for KLKs upon glycosylation. Remarkably, for KLK3/PSA, changes in the glycosylation pattern were observed in samples of benign prostatic hyperplasia and prostate cancer with respect to healthy individuals. Potential functions of KLK glycosylation in structural stabilization, protection against degradation, and activity modulation of substrate specificity can be deduced from a comparison with other glycosylated proteins and their regulation. According to the new concept of protein sectors, glycosylation distant from the active site might significantly influence the activity of proteases. Novel pharmacological approaches can exploit engineered glycans in the therapeutical context.

What's at Stake in the Lives of People With Intellectual Disability? Part I: The Power of Naming, Defining, Diagnosing, Classifying, and Planning Supports

This article focuses on the power of naming, defining, diagnosing, classifying, and planning supports for people with intellectual disability. The article summarizes current thinking regarding these five functions, states the essential question addressed by the respective function, and provides an overview of the high stakes involved for people with intellectual disability, their families, and the field of intellectual disability.

New Insights into Ligand-Receptor Pairing and Coevolution of Relaxin Family Peptides and Their Receptors in Teleosts

Relaxin-like peptides (RLN/INSL) play diverse roles in reproductive and neuroendocrine processes in placental mammals and are functionally associated with two distinct types of receptors (RXFP) for each respective function. The diversification of RLN/INSL and RXFP gene families in vertebrates was predominantly driven by whole genome duplications (2R and 3R). Teleosts preferentially retained duplicates of genes putatively involved in neuroendocrine regulation, harboring a total of 10-11 receptors and 6 ligand genes, while most mammals have equal numbers of ligands and receptors. To date, the ligand-receptor relationships of teleost Rln/Insl peptides and their receptors have largely remained unexplored. Here, we use selection analyses based on sequence data from 5 teleosts and qPCR expression data from zebrafish to explore possible ligand-receptor pairings in teleosts. We find support for the hypothesis that, with the exception of RLN, which has undergone strong positive selection in mammalian lineages, the ligand and receptor genes shared between mammals and teleosts appear to have similar pairings. On the other hand, the teleost-specific receptors show evidence of subfunctionalization. Overall, this study underscores the complexity of RLN/INSL and RXFP ligand-receptor interactions in teleosts and establishes theoretical background for further experimental work in nonmammals.