Dorsoradial Ligament Reconstruction in Trapeziometacarpal Joint Arthritis

Background The main purpose of the study is to present the alternative novel surgical technique in treating patients with trapeziometacarpal (TMC) joint arthritis using dorsoradial ligament (DRL) reconstruction technique and report the clinical outcomes. Methods Patients who were diagnosed with TMC joint arthritis and underwent DRL reconstruction were evaluated. Visual analog pain score; Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score; grip, tip pinch, tripod pinch, and key pinch strengths along with range of motion of the thumb; and Kapandji score were recorded in the preoperative period and at follow-up. Stress examination was also performed under a fluoroscope. Results Eleven patients were included in the study. Median follow-up time was 13 months. At follow-up, postoperative visual analog scale and QuickDASH score improved in all patients. Grip, tip pinch, tripod pinch, and key pinch strengths also improved. The range of motion and Kapandji score were slightly improved compared with the preoperative period except for the thumb metacarpophalangeal flexion. Two patients had numbness at the thumb and spontaneously recovered after 3 months. Conclusions According to recent evidence which proposed the importance of DRL in TMC joint stability, our DRL reconstruction technique may be an alternative treatment in treating patients presented with TMC joint arthritis. Further study with a longer follow-up period is needed.

CORRELATION BETWEEN STRESS AND TEMPOROMANDIBULAR DISORDER IN ORPHANED ADOLESCENT IN BANJARMASIN

ABSTRACTBackground: Temporomandibular disorder is a temporomandibular joint disturbance characterized with the pain in masticatory muscle and TMJ; clicking in TMJ; and deflection, deviation pattern with limitation in opening of the mouth. TMD can be found in adolescents with prevalence and severity increased along with the age. TMD in adolescent was caused by the increased of the masticatory muscle activity. In adolescent, it was caused by the increase of the emotional state especially stress. Stress is a condition that often experienced by every people including orphaned adolescent, who has more problems than the other adolescent. Purpose: The aim of this study was to analyze the correlation between stress and temporomandibular disorder in orphaned adolescent in Banjarmasin. Method: This study is an analytical observational research with cross sectional design. The study was involving 13-18 years old orphaned adolescents in Banjarmasin with purposive sampling. This study is using PSS for stress examination and RDC/TMD for TMD examination. The correlation between stress and TMD were analyzed with Spearman analysis test. Results: This research showed that 61% of the subject had moderate stress level and TMD was found in 68.3% of the subject, which consists of 58.5% had myofascial pain and 9.8% had disc displacement. Spearman analysis test showed that there is statistical correlation between stress and temporomandibular disorder in orphaned adolescent in Banjarmasin (p<0.05). Conclusion: There is a correlation between stress and temporomandibular disorder in orphaned adolescent in Banjarmasin. Keywords: Myofascial Pain, Stress, Temporomandibular disorder (TMD).

Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells

Despite considerable efforts, mTOR inhibitors have produced limited success in the clinic. To define the vulnerabilities of mTORC1-addicted cancer cells and to find previously unknown therapeutic targets, we investigated the mechanism of piperlongumine, a small molecule identified in a chemical library screen to specifically target cancer cells with a hyperactive mTORC1 phenotype. Sensitivity to piperlongumine was dependent on its ability to suppress RUVBL1/2-TTT, a complex involved in chromatin remodeling and DNA repair. Cancer cells with high mTORC1 activity are subjected to higher levels of DNA damage stress via c-Myc and displayed an increased dependency on RUVBL1/2 for survival and counteracting genotoxic stress. Examination of clinical cancer tissues also demonstrated that high mTORC1 activity was accompanied by high RUVBL2 expression. Our findings reveal a previously unknown role for RUVBL1/2 in cell survival, where it acts as a functional chaperone to mitigate stress levels induced in the mTORC1-Myc-DNA damage axis.

Aluminium stress examination of Pasaman local brown rice genotypes in early phase

One of brown rice resistance is tolerant to Aluminium stress. The research was conducted in Seed Technology Laboratory and shade net house of Faculty of Agriculture, Andalas University form March to June 2017. The research aimed to study the tolerance of 6 Pasaman brown rice genotypes to Al stress. Factorial design in Completely Randomized Design was used in this research. The first factor was brown rice genotypes, Sigambiri,LadangTalamau, SikarojukSilomlomPulen and Perbatasan. The second factor was AlCl3 doses, 0 ppm, 5 ppm, 10 ppm, 15 ppm and 20 ppm. The data was analysed by F test and extended by Duncan’s New Multiple Range Test in 5%. The result showed that there was interaction between Al concentration and 6 brown rice genotypes for height of plant, length of leaves. Based on tolerance level, all genotypes were grouped to Moderate-Tolerant level.

Results of the Gravity Stress Examination in the Normal Patient Population

In ankle fractures, the result of a gravity stress radiographic examination is clinically used to determine if a patient may need surgical intervention. The purpose of this study is to report the results of a gravity stress examination in the normal patient population. Fifty study participants were prospectively enrolled and complete ankle radiographs were obtained, including a nonweightbearing gravity stress examination. The mean medial clear space in the gravity stress view was 3.6 mm. This compared to a mean medial clear space of 3.3 mm, and 3.1 mm in the anteroposterior and mortise views. These values were statistically significantly different from the gravity stress view ( P = .006 and P < .001, respectively). There was no statistically significant difference between the talar tilt as measured on the anteroposterior and gravity stress radiographs ( P = .22). No participant had medial clear space widening with gravity stress to more than 5.2 mm or an increase in their widening by more than 0.2 mm. In conclusion, this study helps guide surgeons by providing normative radiographic data for a gravity stress examination and supports the notion that measureable medial clear space widening or talar tilt on gravity stress examination represents an unstable injury. Levels of Evidence: Level II: Prospective