lymphocyte mitogenesis
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2001 ◽  
Vol 47 (3) ◽  
pp. 258-271 ◽  
Author(s):  
Humitoshi Sakazaki ◽  
Hitoshi Ueno ◽  
Kaori Umetani ◽  
Hideo Utsumi ◽  
Katsuhiko Nakamuro

2000 ◽  
Vol 7 (2) ◽  
pp. 68-76 ◽  
Author(s):  
Edward Baral ◽  
Eva Nagy ◽  
Siuchan Kwok ◽  
Archibald McNicol ◽  
Jon Gerrard ◽  
...  

1995 ◽  
Vol 20 (8) ◽  
pp. 821-835 ◽  
Author(s):  
Alexander W. Kusnecov ◽  
Michael R. Shurin ◽  
Ada Armfield ◽  
Jennifer Litz ◽  
Paul Wood ◽  
...  

Endocrinology ◽  
1994 ◽  
Vol 135 (6) ◽  
pp. 2351-2357 ◽  
Author(s):  
G J Wiegers ◽  
J M Reul ◽  
F Holsboer ◽  
E R de Kloet

1994 ◽  
Vol 82 (1) ◽  
pp. 105-111 ◽  
Author(s):  
Harald R. Rosen ◽  
Christoph Ausch ◽  
Georg Reiner ◽  
Marta Reinerova ◽  
Jurai Svec ◽  
...  

1993 ◽  
Vol 265 (6) ◽  
pp. E825-E830 ◽  
Author(s):  
G. J. Wiegers ◽  
G. Croiset ◽  
J. M. Reul ◽  
F. Holsboer ◽  
E. R. de Kloet

The effects of corticosteroids were studied on the concanavalin A (Con A)-induced mitogenesis of peripheral blood T-lymphocytes obtained from intact and adrenalectomized (ADX) Wistar rats. One week of adrenalectomy reduced the proliferative response of T-cells by 65% compared with sham-operated controls. Substitution of ADX rats with subcutaneously implanted 12.5-mg corticosterone (Cort) pellets, which resulted in low circulating Cort levels (17 +/- 3 nM), restored the reduced proliferative capacity to that of sham-ADX animals. In contrast, T-lymphocyte proliferation was nearly absent in ADX rats substituted with high circulating Cort levels (173 +/- 15 nM; 100-mg Cort pellet). In vitro, Cort suppressed the mitogenic response of T-lymphocytes from ADX and sham-ADX animals. The glucocorticoid antagonist RU-486 (500 nM) completely blocked this suppressive effect. However, a 10 times lower concentration of RU-486 reversed the effects of a low (10 nM) Cort concentration from suppression to stimulation. It is concluded that high Cort concentrations in vivo and in vitro suppressed T-lymphocyte mitogenesis but that low concentrations in vivo were stimulatory, whereas this stimulation in vitro occurred only in the presence of antiglucocorticoids. These opposing effects of Cort emphasize a bimodal regulatory role of this hormone in immune regulation that may be mediated by different corticosteroid receptors.


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