Research of the choice of the basis of a semi-solid medicine with a semi-solid extract of Feverfew (Tanacetum parthenium)

The aim. To conduct the research on the choice of the basis for a mild drug with a semi-solid extract of feverfew for use in dermatology. Materials and methods. In the study of the solubility of a semi-solid extract of feverfew (SSFE) used the method of optical microscopy using a laboratory microscope “Konus Academy”. Determination of pH and homogeneity of the studied samples was performed according to the methods described in SPhU, Vol.1. The bioavailability of the model samples was investigated by diffusion in 3 % agar gel. Colloidal stability and thermal stability were determined according to the methods of GOST 29188.3-91. Measurements of rheological parameters were performed on a rotary viscometer “MYR 3000 V 2R” (Viskotech, Spain). Determination of particle distribution was performed using a laser diffraction analyzer of particle size Mastersizer 3000. Results. The best results in determining the organoleptic properties, stability and degree of release of biologically active substances (BAS) showed samples prepared on emulgel and gel bases. Structural and mechanical parameters of the samples on these bases proved the presence of a non-Newtonian type of flow with plastic and thixotropic properties. When determining the distribution of SSFE particles by optical diffraction, their smaller size was determined in the sample on an emulgel basis in comparison with the gel. Conclusions. Emulgel loaded with specific drugs has been found effective in some topical disorders, and it is emerging as potential drug delivery system in the area of dermatology. Since emu-lgel shows enhanced spreadability, adhesion, viscosity and extrusion. Based on the obtained results, an emulsion gel base was chosen as a carrier for a semi-solid drug with SSFE

Convective Transport of Fluid–Solid Interaction: A Study between Non-Newtonian Casson Model with Dust Particles

The Casson model is a fascinating model, which is genuinely recommended for use with fluids of a non-Newtonian type. The conventional model is not capable to represent the Casson model with the suspension of foreign bodies (dust particles). Due to this, the two-phase model for the mixture of Casson model fluid and dust particles is formulated. This study examines the emerging role of dust particles in changing the behavior of Casson model. In particular, two-phase flow of dusty Casson model with modified magnetic field and buoyancy effect under Newtonian heating boundary condition along a vertically stretching sheet is considered. The equations that govern under Casson model, together with dust particles, are reduced to a system of nonlinear ordinary differential equations by employing the suitable similarity variables. These transformed equations are then solved numerically by implementing the Runge–Kutta–Fehlberg (RKF45) method. The numerical results of skin friction coefficient plus Nusselt number are displayed graphically. The results revealed the fluid’s velocity tends to deteriorate due to the existence of dust particles, whilst its temperature is increased. The two-phase flow is one of the mathematical modeling techniques for multiphase flow, where the relationship between the fluid and solid is examined more closely. It is expected that the present findings can contribute to the understanding of the theory of two-phase flow mathematically, which will continue to produce significant research in this field.

Toward Interactions through Information in a Multifractal Paradigm

In a multifractal paradigm of motion, Shannon’s information functionality of a minimization principle induces multifractal–type Newtonian behaviors. The analysis of these behaviors through motion geodesics shows the fact that the center of the Newtonian-type multifractal force is different from the center of the multifractal trajectory. The measure of this difference is given by the eccentricity, which depends on the initial conditions. In such a context, the eccentricities’ geometry becomes, through the Cayley–Klein metric principle, the Lobachevsky plane geometry. Then, harmonic mappings between the usual space and the Lobachevsky plane in a Poincaré metric can become operational, a situation in which the Ernst potential of general relativity acquires a classical nature. Moreover, the Newtonian-type multifractal dynamics, perceived and described in a multifractal paradigm of motion, becomes a local manifestation of the gravitational field of general relativity.

Newtonian-Type Adaptive Filtering Based on the Maximum Correntropy Criterion

This paper provides a novel Newtonian-type optimization method for robust adaptive filtering inspired by information theory learning. With the traditional minimum mean square error (MMSE) criterion replaced by criteria like the maximum correntropy criterion (MCC) or generalized maximum correntropy criterion (GMCC), adaptive filters assign less emphasis on the outlier data, thus become more robust against impulsive noises. The optimization methods adopted in current MCC-based LMS-type and RLS-type adaptive filters are gradient descent method and fixed point iteration, respectively. However, in this paper, a Newtonian-type method is introduced as a novel method for enhancing the existing body of knowledge of MCC-based adaptive filtering and providing a fast convergence rate. Theoretical analysis of the steady-state performance of the algorithm is carried out and verified by simulations. The experimental results show that, compared to the conventional MCC adaptive filter, the MCC-based Newtonian-type method converges faster and still maintains a good steady-state performance under impulsive noise. The practicability of the algorithm is also verified in the experiment of acoustic echo cancellation.

RESEARCH OF RHEOLOGICAL PROPERTIES OF MEDICINAL SYRUP FOR ORAL USE

The aim of the present research was to investigate the rheological properties of the medicinal syrup for oral administration with glucosamine hydrochloride and levocarnitine. Matherials and methods: Coefficient of the dynamic flow (at shear rates of 3,49 and 10,3 s -1, as well as at shear rates of 27.2 and 149.0 s-1), mechanical stability, the index of destruction and restoration were studied. The rheological (structural-mechanical) properties of the samples were determined using a Rheolab QC rotary viscometer (AntonPaar, Austria) with coaxial cylinders CC27 / S-SN29766. The rheological parameters were studied at the temperature 20±0,5 °С. Results: It is established that the syrup has weakly expressed plastic viscous and thixotropic properties (the hysteresis area for the syrupis 1710.19 Pas/s). Such results characterize the system as a reopex. Conclusions: The results of the study enables classification of the research object as system with a low degree of fluidity. Such dependence is typical for systems of the Newtonian type of flow and characterizes the syrup under investigation as a weakly structured disperse system.

Velocity Profile of Fluid Particle Suspension over a Horizontal Plate with Electrification of Particles

The modelling of electrified flow over a horizontal plate is considered. Here the fluid is of Newtonian type and fluid-fluid, fluid- particles collisions are accounted. The effective volumetric force, viscous dissipation, browanion diffusion, in fluid phase as well as particle phase has been considered. In this paper we considered the generation of electricity due to hitting of particles with each other and with the wall of the flow and its impact on motion of flow particles. The systems of equations representing the flow are solved by finite difference method. It concludes from outcome of computation that the particle velocity rises with rise of electricity generation and increasing size of particles.

The Hawking Temperature Intensive Crisis and a Possible Solution that Leads to an Intensive Schwarzschild Surface Temperature

Crothers and Robitaille have recently pointed out that the Hawking temperature and the Unruh temperature are not intensive and how this is inconsistent with thermodynamics, which suggests that the theory around the temperature of black holes is flawed, incomplete, or at least not fully understood. Here we offer a modified Newtonian type acceleration field linked to the Planck scale that leads to a new modified intensive Schwarzschild surface temperature for so-called black holes.

Influence of Total Inertia Effects in a Thrust Curvilinear Bearing Lubricated with Newtonian Lubricants

In the paper, the flow of a Newtonian type of lubricant in the clearance of a curvilinear bearing is considered. It is assumed that the bearing walls are modelled as smooth and impermeable. In analytical considerations, full inertia of the longitudinal flow and partial inertia of the circumferential flow are taken into account. The equation of motion of the lubricant is solved by the modified method of averaged inertia. A thrust bearing and spherical bearing are considered, for which dimensionless pressure distributions and the bearing capacity are given.

Numerical and Analytical Investigation of Viscous Fluids in a Screw Extruder

This study presents a flow model for a single screw extruder which has been investigated by means of analytical and numerical methods. Flow phenomena in single screw extruders has evoked attention of many researchers since non-Newtonian type of fluid transport by an extruder is utilized in many industrial applications. In this study we focused on the Newtonian-type of fluid transport by a single screw extruder since we aimed to generate an analytical model for the simplified Navier-Stokes equations under certain boundary conditions. The analytical model for a steady, laminar, isothermal and incompressible flow is derived using integral transform technique for a highly viscous flow where the convective acceleration terms are assumed to be negligible. Numerical investigation is conducted by an incompressible, laminar, finite volume based flow solver using a Volume of Fluid (VoF) approximation. An appropriate single-screw extruder model is used for the simulations. The novelty of the study relies on the usage of a simplified analytical model for a highly viscous flow and the comparison between the analytical and numerical results where the numerical results are obtained by a two-phase flow solver for the full Navier-Stokes equations using the complex extruder geometry.