tiarella polyphylla
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2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110169
Author(s):  
Ha-Rim Kim ◽  
Sol Kim ◽  
Eun Yee Jie ◽  
Sang Jun Kim ◽  
Woo Seok Ahn ◽  
...  

Ultraviolet (UV)-irradiation causes an overproduction of matrix metalloproteinases (MMPs) and collagen (COL) degradation causing skin sunburn, inflammation, or photoaging in human. In this study, we prepared callus from Tiarella polyphylla D. Don ( T. polyphylla) stem and its phytochemical profiles were analyzed using HPLC-MWD. The effects of T. polyphylla callus extract evaluated against on UVB-induced damage in human foreskin fibroblast (Hs68). Hs68 was exposed to UVB in the presence or absence of T. polyphylla callus extract at concentrations of 100 and 250 µg/mL. Cell damage caused by UVB was inhibited by T. polyphylla callus extract, which was tested by cell viability and caspase 3 activity in Hs68 cells. Further experiment revealed that T. polyphylla extract suppressed the level of MMP-1, but increased the level of type I procollagen. In addition, T. polyhylla callus extract inhibited UVB-mediated COL (-1 and -3) protein degradation and MMP (-1, 2, and -3) overexpression in Hs68. These results suggest that T. polyphylla callus extract has considerable potential as a cosmetic ingredient with anti-aging effects.


Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
OK Kwon ◽  
KS Ahn ◽  
G Shen ◽  
SR Oh ◽  
HK Lee

2008 ◽  
Vol 31 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Guanghai Shen ◽  
Sei-Ryang Oh ◽  
Byung-Sun Min ◽  
Joongku Lee ◽  
Kyung Seop Ahn ◽  
...  

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