Minat Berwirausaha Dampak Efikasi Diri, Motivasi dan Lokus Kendali Pada Mahasiswa

Higher education in a place of final educationwhich has an important role in creating human resources who are able to compete in the world of work. Business development that is done by students is growing, especiallyin the city of Surabaya. Tecresearch of population was Surabaya students the samples were determinated using the simple random sampling method. Data were collected by means of a questionnaire to 75 responden. The purpose of the research is to determine the interest in doing business is the impact of Self – Efficacy, Motivation and locus of control. The results of study show that interest in doing business is a significant impact of self-ethification, this can be seen from t count3.801>t table 1.99394 and a significant value of 0.00< 0.05 and from the control locus it can be seen from t count -3.081>-1.99394 and the significant value is 0.003<0.05, while motivation has no impacton the interest in doing business, it can be seen from the t count 1.565< t table 1.99394 and the significant value 0.112 > 0.05. So it can be concluded that interest in trying to impact to impact from of self-ethics and locus of control

Rhesus Macaques As a Preclinical Model Organism for RUNX1-FPD

Germline loss-of-function (LOF) heterozygous mutations in the central hematopoietic transcription factor RUNX1 gene cause the marrow failure/malignancy predisposition syndrome Familial Platelet Disorder with associated Myeloid Malignancies (FPDMM, or FPD). Patients with FPD have defective megakaryocytic development, low platelet counts, and a very high (35-50%) life-long risk of hematological malignancies, particularly MDS/AML. Murine heterozygous gene knockout models do not recapitulate the human phenotype in terms of thrombocytopenia or myeloid leukemia progression. Although gene correction of the RUNX1 mutation in hematopoietic stem and progenitor cells (HSPCs) is being considered as a possible treatment approach, it is unknown whether mutation-corrected HSPCs will have the hoped for advantage over RUNX1 mutant HSCs in vivo, likely necessary to significantly lower leukemia risk. In order to study the relative function of wildtype and RUNX1-mutated HSPCs in vivo in a model with close hematopoietic similarity to humans, we generated a rhesus macaque FPD competitive repopulation model via CRISPR/Cas9 NHEJ editing of the RUNX1 gene versus the AAVS1 safe-harbor control locus. We transplanted mixtures of autologous HSPCs edited at the two loci: 75% RUNX1-edited/25% AAVS1- edited CD34+ HSPCs in animal 1 and 25% RUNX1-edited/75% AAVS1-edited CD34+ HSPCs in animal 2, following conditioning with total body irradiation. Both animals engrafted tri-lineage hematopoiesis promptly following transplantation. However, platelet numbers remained below the normal range long-term in animal 1 receiving a higher ration of RUNX1-edited HSPCS and below counts of macaques receiving HSPCs edited at other loci (Figure 1). Bone marrow morphology at 6 months was normal. To assess the HSPC function of RUNX1 mutant versus AAV1 control and unedited WT cells we tracked RUNX1 and AAVS1-mutated allele frequencies in blood cells over time via deep sequencing (Figure 2). In the infusion products (IP), allele fractions reflected the desired ratios. In both animals, AAVS1-edited cells dominated compared to RUNX1-edited cells. However, in animal 1, RUNX1-mutated cells expanded over time eventually exceeding the ratio in the IP, and in animal 2, levels of RUNX1 and AAVS1-mutated cells were equivalent long-term. Marrow analyzed at 6 months showed heterozygous RUNX1-mutated CFU at levels concordant with mutation frequencies in the blood, but no homozygous RUNX1 mutated CFU, suggesting homozygous LOF is not compatible with long-term HSPC function. In conclusion, we have created pre-clinical model for FPD via CRISPR/Cas editing of HSPCs in rhesus macaques. The lack of a competitive advantage for wildtype or control-locus edited HSPCs over RUNX1 heterozygous-mutated HSPCs long-term in our model suggests that gene correction approaches for FPD will be challenging, particularly to reverse the MDS/AML predisposition phenotype. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

Studying the level of subjective control as a factor of students’ readiness for family life

В статье предпринята попытка осмысления факторов, оказывающих влияние на формирование готовности студентов к семейной жизни. Обозначены наиболее существенные трудности, которые испытывает современная семья. Представлены эмпирические данные выявления уровня субъективного контроля (локуса контроля) студенческой молодежи по следующему алгоритму: изучение общей интернальности / экстернальности, исследование локуса контроля в области межличностных и семейных отношений, выявление особенностей мотивации (стремление к достижению успеха – преобладание мотива избегания неудач). На основе представленного диагностического исследования выявлены основные трудности, с которыми сталкиваются молодые люди при локализации контроля в области личных и семейных отношений, в сфере принятия ответственных решений; а также предложены пути формирование ценностного отношения молодых людей к семье и браку. The authors attempt to analyze the factors influencing the formation of students’ readiness for family life. The article outlines the most considerable difficulties faced by a modern family. It presents the empirical data on researching the level of subjective control (locus of control) of student youth according to the following algorithm: studying general internality and externality, studying locus of control in the area of interpersonal and family relations, and revealing peculiarities of motivation (striving for success or avoiding failures). Based on the presented research, the authors reveal the main difficulties faced by young people during localization of control in interpersonal and family relations. Finally, the article suggests the ways of forming young people’s value attitude to family and marriage.

PSYCHOLOGICAL AND PEDAGOGICAL CONDITIONS FOR FORMING PROFESSIONAL-IMPORTANT QUALITIES IN ATHLETES

The study of the conditions for the formation of professionally important qualities in athletes is due to the fact that every year in sports of the highest achievements the level of physical complexity and psychological endurance rises, new records are set, the requirements for professional training and the personality of an athlete increase. The article discusses the issues of psychological and pedagogical conditions in the formation of professionally important qualities in athletes. The aim of the study is to identify the psychological and pedagogical conditions for the formation of professionally important qualities in athletes. The content of the article includes a theoretical analysis of the psychological and pedagogical literature of the concepts of "condition", "pedagogical conditions", "psychological conditions". The author's vision on the definition of the concepts of "psychological and pedagogical conditions in sports", "professional qualities of an athlete" is given, as well as the characteristics of these conditions that contribute to the formation of professionally important qualities in athletes, and provide psycho-emotional stability. According to the authors, the professionally important qualities of an athlete (PVK) are individual psychological and physiological qualities that affect his effectiveness in sports activity. These include psychoemotional stability, self-reflection, motivation, resilience, concentration of attention, self-regulation, self-control, locus control (localization of control of volitional effort), etc. The main result of the study is the concretization of conditions that contribute to the formation of professionally important qualities necessary for the implementation of successful sports activity. The authors refer to the psychological and pedagogical conditions: ensuring a favorable socio-psychological climate in the team, relationships and the creation of psychological safety; ensuring the consistency of the athlete's psychological training; providing psychological and pedagogical debriefing; improvement of educational and methodological, scientific and methodological support of the psychological training of an athlete; psychological and pedagogical competence of a trainer through refresher courses; organization of scientific and practical conferences, symposia, forums; implementation of digitalization in sports.

PENERAPAN SISTEM INFORMASI AKUNTANSI MANAJEMEN TERHADAP KINERJA UMKM MELALUI LOCUS OF CONTROL

Pandemi covid-19 ini menyebabkan sebagian besar UMKM mengalami gulung tikar sehingga diperlukan adanya usaha ataupun strategi yang digunakan untuk mengatasi permasalahan tersebut untuk menjaga keberlangsungan hidup UMKM. Dalam perkembangan teknologi informasi karakteristik sistem informasi akuntansi manajemen sangatlah penting untuk mendukung pertumbuhan UMKM. Namun perkembangan teknologi informasi tumbuh dalam kondisi lingkungan yang sulit diprediksi sehingga kondisi tersebut dapat mempengaruhi locus of control yang dampaknya dapat mempengaruhi kinerja UMKM. Populasi penelitian ini meliputi semua pelaku UMKM di wilayah Pasuruan dan Malang yang masih aktif usahanya. Menurut data dari Dinas Koperasi, Perindustrian dan Perdagangan, jumlah UMKM sebanyak 1625 unit dengan berbagai sektor. Teknik pengambilan sampel yang digunakan adalah metode purposive sampling. Sampel yang diambil sebesar 20% dari jumlah populasi sehingga diperoleh sampel sebesar 325 responden. Teknik analisis yang dipilih untuk menganalisis data dalam penelitian ini adalah analisis faktor konfirmatori dan maximum likehood estimation pada SEM (Structural Equation Model) dengan menggunakan aplikasi STATA 14. Dari hasil penelitian diketahui bahwa sistem informasi akuntansi manajemen berpengaruh positif dan signifikan sebesar 0,27 terhadap kinerja UMKM. Sistem informasi akuntansi manajemen berpengaruh positif dan signifikan sebesar 0,77 terhadap Locus of control. Locus of control berpengaruh positif dan signifikan sebesar 0,34 terhadap kinerja UMKM. Sistem informasi akuntansi manajemen berpengaruh positif dan signifikan sebesar 0,26 terhadap kinerja UMKM melalui Locus of control. Hasil penelitian ini menjelaskan bahwa Keberhasilan UMKM yaitu ada pada kemampuan diri (locus of control) dalam mengendalikan permasalahan yang terjadi di perusahaan. Kemampuan perusahaan dalam menggunakan sistem informasi akuntansi manajemen dengan adanya locus of control dari pelaku (UMKM) sehingga dapat meningkatkan kinerja UMKM.

Ageism attitudes of Ukrainian students

Introduction. The article is devoted to the study of factors that determine the students’ ageism attitudes, as well as their perception of the image “I am the old”.Aim. To investigate the connection between ageism attitudes with the indicators of conformism and control locus.Materials and methods. Sample: 100 students of the Faculty of Psychology, Taras Shevchenko National University of Kyiv (specialty “social pedagogy” and “social work”). Toolkit: Leary interpersonal communication skills test, The level of empathy test (I. Yusupov), Big-5 personality questionnaire, The locus of control test (J. Rotter), Questionnaire of ageism attitudes (E. Krainikov).Results. Younger youths are more conformal and less empathic than older youths. Regarding the openness to the new experience, there were no significant differences between the respondents of both groups. Older youths are characterized by internal control locus comparing to younger youths. In addition, older youths have more positive and objective view to aging and old age. On the contrary, younger youths are more biased towards aging and old age.Conclusions. The low level of conformism contributes to the formation of positive ageism attitudes, with the relative adoption of the image “I am the old”; the average level of conformism contributes to a balanced approach to aging and old age; a high level of conformism contributes to the formation of a negative ageism attitudes, testifies to the rejection of the image “I am the old”. Also, the ageism attitudes are affected by the level of subjective control. The internal control locus correlates with more positive ageism attitudes. Youth associates with a decrease in the level of conformism and increased control of the internal locus; therefore, older youths show more positive ageism attitudes and are likely to adopt the image “I am the old”.