Non-Invasive Monitoring of the Technical Condition of Power Units Using the FAM-C and FDM-A Electrical Methods

This article presents the selected results of analytical and structural work conducted at the Air Force Institute of Technology (pl. ITWL) in the field of building a measuring apparatus for non-invasive monitoring of the technical condition of aircraft power units. Presented innovative FAM-C and FDM-A methods allow for observation of frequency modulation parameters as well as identification and diagnostic classification of particular mechanical subassemblies supplying the on-board generator and thus enable non-invasive monitoring of technical condition of the aircraft power unit and the aircraft propulsion system. The main purpose of this article is to present the measurement apparatus errors that occur in the signal conditioning system in the FAM-C and FDM-A methods. In spite of the fact that the measuring instrument was built on the basis of digital technology and that it uses typical solutions of electronic frequency measurement, due to the specificity of the applied diagnostic method there occur specific measuring errors which are presented in this article.

Conceptual Robot Design For The Automated Layout of Building Structures By Integrating QFD And TRIZ

According to the increase in building size and lack of skilled laborers, layout operation has high demands on automation for productivity and quality improvement. With such a background, research has been recently undertaken to develop an automated layout system based on marking robots for structural work in Korea. Although there are several robot-based automation systems under development targeted at interior works, the system for structural work has different functional needs and technical requirements in designing the robots compared with the existing ones. Therefore, this study proposes a conceptual robot design for an automated layout of building structures, based on a systematic design process, by integrating quality function deployment (QFD) and the theory of creative problem solving (TRIZ). With the support of the approach, 11 user requirements and 16 relevant technical characteristics were derived and prioritized, and 15 creative ideas were derived to solve the technical contradictions. The selected design solution improves driving speed by separating driving and marking operations, and the two-wheeled steering drive system with a suspension device allows easier driving control in a narrow and uneven driving environment. The noncontact type of printer head also minimizes the complexity of the device and provides excellent performance in securing marking precision and quality in response to floor conditions. The results of this study will be used for the detailed design of the layout robot system, and the design process can be utilized for designing and evaluating other construction robots and automation systems.

Optimalisasi Penjadwalan Proyek Pembangunan Gedung Puskesmas Badas Menggunakan Critical Path Method-Project Evaluation and Review Technique (CPM-PERT)

Lack of project scheduling planning and ineffective control make the activity of a project less efficient. This will have an impact on the success of the project. This situation will result in delays and a decrease in the quality of work due to time constraints. Scheduling is important for determining the required activities and arranging a sequence and time frame to complete project activities on time. This study aims to optimize the scheduling of a moderate light rehabilitation project in the Badas Community Health Center building, Kediri Regency, where project start-ups are experiencing delays. The method used is Critical Path Method-Project Evaluation and Review Technique (CPM-PERT), which is a method to determine the duration of a project that can be completed and the percentage of its success. The analysis carried out includes calculation the duration desired acceleration and cost slope. Analysis results using CPM-PERT obtained critical path in: preparation activities (A), earthworks (B), structural work (D), 1st floor work (E), 2nd floor work (F), 3rd floor work (G), roof, ceiling and plank work (H), iron work (I), electrical work (L), floor and wall covering work (M) and finishing work (N). The normal duration of project completion is 140 days and costs Rp. 1,818,182,709, whereas with the CPM-PERT method the duration can be accelerated to 128 days (probability 99.99%) and required additional fee 8.1% or worth Rp. 146,719,664. Implementers can use it in optimizing scheduling and financing on the badas public health center building construction project.

Structural biology of human telomerase: progress and prospects

Telomerase ribonucleoprotein was discovered over three decades ago as a specialized reverse transcriptase that adds telomeric repeats to the ends of linear eukaryotic chromosomes. Telomerase plays key roles in maintaining genome stability; and its dysfunction and misregulation have been linked to different types of cancers and a spectrum of human genetic disorders. Over the years, a wealth of genetic and biochemical studies of human telomerase have illuminated its numerous fascinating features. Yet, structural studies of human telomerase have lagged behind due to various challenges. Recent technical developments in cryo-electron microscopy have allowed for the first detailed visualization of the human telomerase holoenzyme, revealing unprecedented insights into its active site and assembly. This review summarizes the cumulative work leading to the recent structural advances, as well as highlights how the future structural work will further advance our understanding of this enzyme.

The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities

The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (GR-LBD) have been reported, the functional oligomeric state of the full-length receptor, which is essential for its transcriptional activity, remains disputed. Here we present five new crystal structures of agonist-bound GR-LBD, along with a thorough analysis of previous structural work. Biologically relevant homodimers were identified by studying a battery of GR point mutants including crosslinking assays in solution and quantitative fluorescence microscopy in living cells. Our results highlight the relevance of non-canonical dimerization modes for GR, especially of contacts made by loop L1-3 residues such as Tyr545. Our work unveils likely pathophysiologically relevant quaternary assemblies of the nuclear receptor with important implications for glucocorticoid action and drug design.

An Efficient Image Segmentation Using Partial Differential Equation for Image Processing Applications

Different processing of the images, such as the image captured, saved and retrieved from another use of the specific image, must be restructured in various ways in the process. More methods such as image restoration, picture segmentation, improvement of the picture etc can be used when processing images. Reconstructed in 3D picture 2D pictures are need to be proper. Including geometric wavelets and geometric analysis the structural work focused upon a variational and a selectable differential equation to test PDE’s which is a convergence of stochastic modelling and analysis of harmonics. This paper focuses primarily on the critical reviews of the image segmentation collection with the PDE application as a mathematical method and introduces the key tool of mathematics and techniques along with the literature-based analysis.

Structural basis for potassium transport in prokaryotes by KdpFABC

KdpFABC is an oligomeric K+ transport complex in prokaryotes that maintains ionic homeostasis under stress conditions. The complex comprises a channel-like subunit (KdpA) from the superfamily of K+ transporters and a pump-like subunit (KdpB) from the superfamily of P-type ATPases. Recent structural work has defined the architecture and generated contradictory hypotheses for the transport mechanism. Here, we use substrate analogs to stabilize four key intermediates in the reaction cycle and determine the corresponding structures by cryogenic electron microscopy. We find that KdpB undergoes conformational changes consistent with other representatives from the P-type superfamily, whereas KdpA, KdpC, and KdpF remain static. We observe a series of spherical densities that we assign as K+ or water and which define a pathway for K+ transport. This pathway runs through an intramembrane tunnel in KdpA and delivers ions to sites in the membrane domain of KdpB. Our structures suggest a mechanism where ATP hydrolysis is coupled to K+ transfer between alternative sites in KdpB, ultimately reaching a low-affinity site where a water-filled pathway allows release of K+ to the cytoplasm.

MECHANISMS OF OPERATIONAL PORTFOLIO MANAGEMENT OF PROJECTS IN SHIPBUILDING AND SHIP REPAIR

Over the past decades, the competitiveness of enterprises in the world shipbuilding and ship repair markets is being determined by the level of development of information and communication technologies, on the basis of which global value chains are being formed. The shipbuilding 4.0 methodology is being introduced in the industry, which is based on the advanced technologies of the fourth industrial revolution. The aim of the article is to study the models and mechanisms for portfolio management of shipbuilding and ship repair enterprises on the basis of modern information technology for the effective implementation of strategic goals and sustainable development. The basis of the organizational and methodological support of portfolio management of shipbuilding enterprises is a system of planning and accounting units. This is a three-level model for the shipbuilding work breakdown. The first level of work breakdown consists of shop stages (list of works performed by a certain production department). The second level of work breakdown is technological sets that are being formed in the process of production planning on the principles of structural and technological unity of work and are the basic elements in the intershop operational management. Technological operations are carried out at the third level of work breakdown (brigade sets). At the upper levels of shipbuilding work breakdown, all the key features of project management take place. Technological sets are recommended to be used as an information and analytical basis when developing the network models at the upper levels of structural work breakdown. The methodology for portfolio management of projects of a shipbuilding enterprise described in the article is aimed at aligning the goals and objectives of individual projects and the portfolio as a whole with the strategic plans of the enterprise.