substance k
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2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Jeffrey Barrett ◽  
Brenden Canning ◽  
Joseph Coulson ◽  
Erin Dombrowsky ◽  
Steven D. Douglas ◽  
...  

Tachykinin receptors (provisional nomenclature as recommended by NC-IUPHAR [90]) are activated by the endogenous peptides substance P (SP), neurokinin A (NKA; previously known as substance K, neurokinin α, neuromedin L), neurokinin B (NKB; previously known as neurokinin β, neuromedin K), neuropeptide K and neuropeptide γ (N-terminally extended forms of neurokinin A). The neurokinins (A and B) are mammalian members of the tachykinin family, which includes peptides of mammalian and nonmammalian origin containing the consensus sequence: Phe-x-Gly-Leu-Met. Marked species differences in in vitro pharmacology exist for all three receptors, in the context of nonpeptide ligands. Antagonists such as aprepitant and fosaprepitant were approved by FDA and EMA, in combination with other antiemetic agents, for the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy.


2010 ◽  
pp. 1290-1290
Author(s):  
Michael M. Morgan ◽  
MacDonald J. Christie ◽  
Luis De Lecea ◽  
Jason C. G. Halford ◽  
Josee E. Leysen ◽  
...  
Keyword(s):  

1993 ◽  
Vol 293 (2) ◽  
pp. 325-328 ◽  
Author(s):  
M A Debernardi ◽  
R Munshi ◽  
M Yoshimura ◽  
D M Cooper ◽  
G Brooker

In C6-2B cells, agonist-stimulated cyclic AMP accumulation is inhibited when the cytosolic Ca2+ concentration is increased. We now demonstrate that in C6-2B cells: (i) the early kinetics of the cyclic AMP inhibition by substance K (t1/2 = 35 s) and thapsigargin (t1/2 = 1.6 min) closely mimic the kinetics of the cytosolic Ca2+ increase evoked by either agent (t1/2 = 25 s and 1.5 min respectively); (ii) the Ca2+ rise and cyclic AMP inhibition by substance K or thapsigargin are similarly affected in EGTA-containing medium; (iii) PCR detects type-III and type-VI adenylate cyclase cDNAs, and RNAase protection assays show that the mRNA for type-VI adenylate cyclase, an isoform inhibitable by submicromolar Ca2+ concentrations, is the predominant species, strongly suggesting that type-VI adenylate cyclase is probably the target molecule for Ca(2+)-mediated inhibition of cyclic AMP accumulation.


Peptides 1992 ◽  
1993 ◽  
pp. 667-668 ◽  
Author(s):  
Kiyoshi Nokihara ◽  
Minoru Yamaguchi ◽  
Toshiaki Ohmori ◽  
Atukazu Kuwahara

1992 ◽  
Vol 203 (3) ◽  
pp. 625-631 ◽  
Author(s):  
Johan B. SUNDELIN ◽  
Diego M. PROVVEDINI ◽  
Claes R. WAHLESTEDT ◽  
Henrik LAURELL ◽  
Jens S. POHL ◽  
...  

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