Effects of anxiety on preferences for generic medicines in Australia

Generic medicines have been available to consumers for ∼40 years, with varying degrees of uptake in different countries. Despite offering equivalent therapeutic qualities, generic medicines still struggle to be accepted by consumers. This study examines the role of a consumer’s affective state and framing effects on the purchase of a branded versus a generic pharmaceutical product. These issues are examined in an experiment, with independent manipulations of consumer anxiety levels and the framing of generic alternatives by the pharmacist. The sample comprised 426 men and women within Australia who completed an online survey with a scenario of purchasing a pharmaceutical after visiting a General Practitioner. Results indicate that those consumers experiencing higher levels of anxiety and where the doctor prescribed the branded medicine are more likely to choose branded medicines over cheaper, generic alternatives. The effect of framing the generic alternative as either ‘generic’ or ‘cheaper’ was not significant.

Drug shortages in a pediatric stem cell transplantation ward: Challenges and implications. A 5-year bilan

This article describes the implications of shortages of pharmaceutical products used in conditioning and supportive care regimens of pediatric patients undergoing a hematopoietic stem cell transplantation in a tertiary care hospital. Between July 2011 and July 2016, a total of 84 individual shortages, affecting 22 different drugs (79.8% supportive care drugs; 20.2% chemotherapeutics) were detected with a mean duration of 85 days (SD 138) per individual drug shortage. Eighteen shortages were critical and very urgent. Sulfamethoxazol/trimethoprim, piperacillin/tazobactam, ranitidine, benzylpenicillin, ondansetron (supportive care) and methotrexate, melphalan (chemotherapeutics) had the longest supply disruptions. A variety of solutions could be identified including the purchase of a generic alternative (36.9%) for both oral and parenteral treatments (in a ratio 3:2). Urgent import from another (European) country was performed in 14 cases (16.7%). High impact solutions such as cohorting of patients and change of ongoing treatments (2.4%) were used for parenteral treatments only. Pharmaceutical modification was sometimes applied for oral treatments (2.4%). Due to persistent occurrence of these shortages, an efficient pharmacy workflow (electronic follow-up by end of 2016) and a multidisciplinary approach were needed.

Chemotherapy drug shortages in paediatric oncology: A 14-year single-centre experience in Belgium

Shortages of chemotherapy are a growing challenge for the healthcare system. We present the burden of drug shortages of chemotherapeutics in the paediatric hemato-oncology unit of a tertiary care hospital and solutions that were used to manage them. Between January 2001 and December 2014, 54 individual shortages were detected, affecting a total number of 21 different drugs. In total, 4127 shortage days were registered with a mean duration of 196.5 SD ± 144.0 days per individual drug shortage. Methotrexate, doxorubicin and carboplatin had the longest supply disruptions. Solutions to address the problems were purchase of a generic alternative, a change of individual treatment plans, cohorting of patients and import from abroad.

Characterising Complex Enzyme Reaction Data

The relationship between enzyme-catalysed reactions and the Enzyme Commission (EC) number, the widely accepted classification scheme used to characterise enzyme activity, is complex and with the rapid increase in our knowledge of the reactions catalysed by enzymes needs revisiting. We present a manual and computational analysis to investigate this complexity and found that almost one-third of all known EC numbers are linked to more than one reaction in the secondary reaction databases (e.g. KEGG). Although this complexity is often resolved by defining generic, alternative and partial reactions, we have also found individual EC numbers with more than one reaction catalysing different types of bond changes. This analysis adds a new dimension to our understanding of enzyme function and might be useful for the accurate annotation of the function of enzymes and to study the changes in enzyme function during evolution.

Stereo 3D Mouse Cursor: A Method for Interaction with 3D Objects in a Stereoscopic Virtual 3D Space

We introduce a different approach of applying stereoscopy principles to implement a virtual 3D pointing technique called stereo 3D mouse cursor (S3D-Cursor) based on two or more views of an ordinary mouse cursor. The basics of such an idea have already been applied as a by-product of some stereo-based visualization applications with usually less attention to its strengths or weaknesses as a generic alternative of its 2D counterpart in stereoscopic 3D space. Here, we examine if such an idea satisfies all or the main expected requirements of an abstract 3D cursor. Moreover, we analyze its accuracy and evaluate the applicability of this approach in terms of different efficiency factors. For this purpose, we have adapted a real-time point-based rendering software called QSplat to a multiview rendering version named QSplatMV. We have implemented the S3D-Cursor on top of this new application and developed a simple editing toolset for manipulating the virtual 3D objects. Our user evaluation results suggest the effectiveness of the approach in terms of detection accuracy and user satisfaction compared to using an ordinary mouse cursor on a conventional 2D screen.

Practical Changes to Single-Boom Sprayers for Zone Herbicide Application

Reduced-rate zone herbicide application (ZHA) consists of banding reduced herbicide rates between crop rows (≤ full broadcast registered rate, 1×) and banding much reduced herbicide rates over crop rows (≪ 1×). The objective of this research was to compare the mechanically complicated dual-boom ZHA sprayer with a much simpler, single-boom ZHA sprayer for controlling giant foxtail and common waterhemp in field corn in 2003 and 2004 in Missouri. The dual-boom ZHA sprayer employed two different herbicide solutions, which were propelled through two booms on separate sprayer systems to apply different herbicide rates over in-row and between-row areas while maintaining similar carrier volumes and coverage through two booms. In contrast, the single-boom ZHA sprayer is a mechanically simpler system in which both herbicide rates and carrier volumes were varied across one boom over in-row (IR) and between-row (BR) areas. In single-boom ZHA, two different nozzle tips were alternated on one boom over in-row and between-row areas, the number of nozzles per boom was doubled, and the distance between nozzles was halved compared with a conventional sprayer boom. In a 2-yr study, these different ZHA sprayers were used to apply preemergence atrazine + S-metolachlor between and over crop rows at various reduced rates (1× = 2,240 + 1,750 g ai/ha, respectively). Among all single- and dual-boom ZHA sprayer treatments and the weed-free checks, corn yields and in-row total weed cover were statistically indistinguishable for both years and for between-row total weed cover in 1 of 2 yr. In both years, a single-boom ZHA system prevented yield loss from competing weeds as effectively as the dual-boom ZHA system. The new single-boom ZHA system is a mechanically simple, inexpensive, generic alternative for reducing herbicide rates and lowering input costs.