direct mass measurement
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2015 ◽  
Vol 92 (4) ◽  
Author(s):  
U. Chowdhury ◽  
K. G. Leach ◽  
C. Andreoiu ◽  
A. Bader ◽  
M. Brodeur ◽  
...  

2012 ◽  
Vol 108 (5) ◽  
Author(s):  
M. Brodeur ◽  
T. Brunner ◽  
C. Champagne ◽  
S. Ettenauer ◽  
M. J. Smith ◽  
...  

2008 ◽  
Vol 101 (1) ◽  
Author(s):  
V. L. Ryjkov ◽  
M. Brodeur ◽  
T. Brunner ◽  
M. Smith ◽  
R. Ringle ◽  
...  

2006 ◽  
Vol 15 (07) ◽  
pp. 1471-1475 ◽  
Author(s):  
ZDENĚK DLOUHÝ

The derivation of two-neutron separation energies from the direct mass measurement of the neutron-rich nuclei at GANIL has enabled us to establish new neutron magic numbers N=6 and 16 in neutron-rich region for the first time instead of normal 8 and 20 and to confirm the existence of new doubly magic nuclei 8 He and 24 O . Adjunction of a proton to the new doubly magic nuclei 8 He and 24 O enable to accept two or more neutrons by these nuclei and form, respectively, the neutron halo 11 Li nucleus and create a very neutron-rich set of 27,29,31 F isotopes. The connection between doubly magic nuclei and the neutron halo and/or very neutron-rich odd-Z nuclei is studied by analysis of triton separation energies St of light neutron-rich nuclei.


2005 ◽  
Vol 31 (10) ◽  
pp. S1771-S1774 ◽  
Author(s):  
M Chartier ◽  
M B Gómez Hornillos ◽  
W Mittig ◽  
A Lépine-Szily ◽  
L Caballero Ontanaya ◽  
...  

2004 ◽  
Vol 586 (1-2) ◽  
pp. 27-33 ◽  
Author(s):  
J Stadlmann ◽  
M Hausmann ◽  
F Attallah ◽  
K Beckert ◽  
P Beller ◽  
...  

1997 ◽  
Vol 43 (7) ◽  
pp. 1172-1181 ◽  
Author(s):  
Chuanliang Liu ◽  
Larry D Bowers

Abstract We describe the use of an HPLC/MS technique for the characterization of nicked fragments of hCG β-subunit. After reductive alkylation of the nicked hCG β-subunit with vinylpyridine, endoproteinase Glu-C or trypsin was used to digest the protein to produce peptides that could be analyzed by HPLC/electrospray ionization MS. Human leukocyte elastase digestion was used to produce an experimentally nicked hCG. Two nicking sites were observed, between amino acids 42Thr and 43Arg and between 44Val and45Leu. The former site has not been previously reported for elastase digestion. The structures of the fragments were confirmed by HPLC/MS after removal of the oligosaccharide by direct mass measurement and by mass determination of their proteolytic digests. Without the glycopeptidase treatment, the microheterogeneity of the two N-linked oligosaccharides could be deduced from the spectra of the proteolytic fragments. Nicking with elastase was found to alter the oligosaccharide structures. Nicked β-subunit samples isolated from the urine of choriocarcinoma patients were also analyzed and the location of the nicking site(s) agreed with that determined by classical techniques. Important differences in the oligosaccharide structures were also observed in these samples, including the presence of triantennary oligosaccharides not found in hCG from healthy subjects. These findings demonstrate the potential of HPLC/MS for characterization of glycoprotein standard preparations.


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