Integrated Bioinformatics Analysis for Identification of the Hub Genes Linked with Prognosis of Ovarian Cancer Patients

Background. One of the most usual gynecological state of tumor is ovarian cancer and is a major reason of gynecological tumor-related global mortality rate. There have been multiple risk elements related to ovarian cancer like the background of past cases associated with breast cancer or ovarian cancer, or excessive body weight issues, case history of smoking, and untimely menstruation or menopause. Because of unclear expressions, more than 70% of the ovarian cancer patient cases are determined during the early stage. Material and Methods. GSE38666, GSE40595, and GSE66957 were the three microarray datasets which were analyzed using GEO2R for screening the differentially expressed genes. GO, Kyoto Encyclopedia of Genes, and protein expression studies were performed for analysis of hub genes. Then, survival analysis was performed for all the hub genes. Results. From the dataset, a total of 199 differentially expressed genes (DEGs) were identified. Through the KEGG pathway study, it was noted that the DEGs are mainly linked with the AGE-RAGE signaling pathway, central carbon metabolism, and human papillomavirus infection. The survival analysis showed 4 highly expressed hub genes COL4A1, SDC1, CDKN2A, and TOP2A which correlated with overall survival in ovarian cancer patients. Moreover, the expression of the 4 hub genes was validated by the GEPIA database and the Human Protein Atlas. Conclusion. The results have shown that all 4 hub genes were found to be upregulated in ovarian cancer tissues which predict poor prognosis in patients with ovarian cancer.

Respiratory pathophysiology in obesity

In the modern world, obesity is the most important medical and social problem that requires an interdisciplinary approach. Many diseases of the respiratory system are caused by obesity.Aim. The review analyzes scientific sources on respiratory disorders in patients with obesity from the open-access electronic libraries PubMed and eLibrary published in the last 15 years.Methods. A comparative systematical assessment of the results of these studies was carried out. The mechanical effects of excess body weight on the respiratory apparatus have been singled out. The current views about cellular and humoral effects of adipose tissue on the development of respiratory pathology have been given.Conclusion. The analysis results present evidence of the multifactorial negative influence of excessive body weight on the respiratory system. Some aspects of the role of obesity in the development of respiratory disorders require further study. Understanding the pathogenic mechanisms behind the influence of obesity on the respiratory apparatus is essential for developing the patient management strategy.

The association between living environmental factors and adolescents’ body weight: a cross-sectional study

Background The effect of the living environment on public health has received increasingly scholarly attention. This study aims to explore the relationship between adolescents’ body weight and their living environmental factors. Methods This cross-sectional study comprised 1362 middle-school students from Nanjing and 826 from Changzhou in China. We further collected information on living environmental factors based on their home address and ran multivariate logistic regressions to explore potential correlations after considering a range of potential confounding factors. Results Approximately 25% (n = 303) of students from Nanjing and 26% (n = 205) of students from Changzhou were excessive body weight. In Nanjing, students’ BMI (Body Mass Index) showed a strong negative correlation with the number of sports venues in their neighborhood (Adjusted Odds Ratio (AOR): 0.64, 95%CI: 0.40–0.94) after controlling for other covariates. In Changzhou, we observed a positive correlation between adolescents’ body weight and the number of bus stops in their neighbourhood (AOR:1.63, 95%CI:1.11–2.38). Conclusions The living environment factors were independently associated with teenagers’ excessive body weight. We hypothesis that the environmental risk factors might be associated with political management, which will consequently affect personal health outcomes. Further research and proactive measures are required to manage those potential risks and attenuate the problem.

Overview of The Lifestyle of Hypertension Patients

Hypertension is influenced by several factors such as gender, age, genetics, family history of the disease, excessive salt intake, smoking habits, less than optimal diet (quality and quantity), lack of physical activity, and excessive body weight. The world health organization (WHO) shows that in world data about 39.6% of people suffer from hypertension. Hypertension is usually experienced by late adults or the elderly. According to Riskesdas, the prevalence of hypertension in Indonesia was 25.8% in 2007 with age > 18 years. Research conducted in Jakarta shows that the prevalence of hypertension reaches 20%. Researchers are interested in studying the relationship between lifestyle and the incidence of hypertension. This study aims to determine the description of the lifestyle of patients with hypertension. This study uses a qualitative method by collecting data from interviews which are expressed in words or writing. This study is a study conducted on 4 people with hypertension. The time of the research took place in June 2021. The results of the study obtained that lifestyle greatly affects the incidence of hypertension. Physical activity research was obtained from 4 respondents, most respondents rarely do physical activity and most of them consume foods that are high in salt content.

S-ademetionine in the treatment of non-alcoholic fatty liver disease (NAFLD)

The experimental and clinic data supporting S- ademetionin application in NAFLD complex therapy were presented. The therapy corrects an oxidative stress in hepatocytes and transforms the nutrition behavior in patients with excessive body weight when depressive syndrome is developed.

Excessive Body Weight and Diverticular Disease

<b><i>Background:</i></b> The worldwide proportion of overweight adults almost doubled from 22% in 1975 to 39% in 2016. Comparably, for the USA and Germany in 2016, the proportion was 68 and 56.8%, respectively. In Olmsted County, Minnesota, the prevalence of diverticulitis also doubled between 1980 and 2007, from 19 to 40%. Obesity substantially increases the risk of multiple gastrointestinal (GI) diseases and non-GI diseases. In a narrative review, we examined the evidence on whether obesity also increases the risk for the development of diverticulosis or diverticular disease and its outcome. <b><i>Summary:</i></b> Evidence suggests that being overweight (body mass index ≥25 kg/m²) or obese (≥30 kg/m²), especially viscerally obese, is a risk factor for diverticulosis, diverticular disease and diverticulitis, diverticular bleeding, more severe or complicated disease, recurrent disease, and for worse outcomes after surgery. <b><i>Key Messages:</i></b> There is a well-founded association between overweight and diverticular disease as well as diverticulosis. It is not clear whether overweight per se or confounders linked with it are responsible for the association. However, means to fight the overweight and obesity epidemic might also help to reduce the prevalence of morbidity and mortality from diverticular disease.

Common and Unique Genetic Background between Attention-Deficit/Hyperactivity Disorder and Excessive Body Weight

Comorbidity studies show that children with ADHD have a higher risk of being overweight and obese than healthy children. This study aimed to assess the genetic alternations that differ between and are shared by ADHD and excessive body weight (EBW). The sample consisted of 743 Polish children aged between 6 and 17 years. We analyzed a unique set of genes and polymorphisms selected for ADHD and/or obesity based on gene prioritization tools. Polymorphisms in the KCNIP1, SLC1A3, MTHFR, ADRA2A, and SLC6A2 genes proved to be associated with the risk of ADHD in the studied population. The COMT gene polymorphism was one that specifically increased the risk of EBW in the ADHD group. Using the whole-exome sequencing technique, we have shown that the ADHD group contains rare and protein-truncating variants in the FBXL17, DBH, MTHFR, PCDH7, RSPH3, SPTBN1, and TNRC6C genes. In turn, variants in the ADRA2A, DYNC1H1, MAP1A, SEMA6D, and ZNF536 genes were specific for ADHD with EBW. In this way, we confirmed, at the molecular level, the existence of genes specifically predisposing to EBW in ADHD patients, which are associated with the biological pathways involved in the regulation of the reward system, intestinal microbiome, and muscle metabolism.

Specialties of course of early and late preeclampsia in women in Vinnitsya region

Annotation. Preeclampsia is one of the leading causes of maternal and perinatal death, and it complicates from 5 to 8% of all pregnancies. The aim of the research was to show the differences in anamnesis, diagnostics and prognosis, in groups of pregnant with hypertensive disorders. Retrospective investigation included 138 delivery histories and perinatal record cards from Vinnitsya Municipal Clinical Maternity hospital №1, in a period from 2016 till 2018. Women were divided into two investigated groups: I – 36 women with early preeclampsia, and II group – 52 women with late preeclampsia, and a control group of 50 women. The structure of somatic and gynecological diseases of pregnant women was studied, the severity of preeclampsia and the condition of the newborn were assessed according to the Apgar scale. Statistical processing of the obtained results was performed by odds ratio, its standard error and 95% confidence interval were calculated according to D. G. Altman (1991). It is established that in women with obesity or excessive body weight (every second women in groups), and those who had cardiovascular disorders (twice more often with late preeclampsia) developed preeclampsia more often, comparing to control group. All cases of antenatal and early neonatal death of newborn were registered in a group with early preeclampsia, which points out on heavier flow of the disease and different pathogenesis. Cases of early pregnancy toxemia and edema of pregnant occurred twice more often, in group with early preeclampsia, and ran more heavy (up to the development of ascites), comparing to the second group. Debut of symptoms was earlier, that requires earlier prophylaxis (since week 12). Fetal intrauterine growth retardation, reversible and high resistant blood stream during ultrasound were marked only in group with EP. In future, this research together with pathohistological investigation of placentas and immunohistochemical research of those tissues, can underlie predictive and preventive personalized system for early and late preeclampsia.

THE ROLE OF OBESIT Y IN THE DE VELOPMENT OF VITAMIN D DEFICIENCY RICKETS IN CHILDREN

Vitamin D deficiency rickets is one of the most common diseases among children of the first years of life in many countries around the world. It is very important to understand the aforementioned nosological unit as a metabolism disorder, and not just as a D-deficiency state. In modern conditions, the risk factors for vitamin D deficiency rickets have undergone further study. The results of the research indicate that obesity is one of the risk factors for vitamin D deficiency in children. Thus, vitamin D metabolism, deposition, bioavailability and its biological role are dependent on the size of adipose tissue. The pathogenetic interaction between obesity andМvitamin D deficiency is probably predetermined by several mechanisms. Firstly, in case of obesity, vitamin D,Мwhich is a fat-soluble substance, is distributed in a considerable amount of adipose tissue, which leads toa decrease in its concentration in the blood plasma. Secondly, with excessive body weight there is a limitation of vitamin D bioavailability, caused by vitamin D capture with adipocytes and depositing in adipose tissue.Thirdly, there is a genetic proof that the increase in BMI leads to a decrease in vitamin D levels in blood serum.Recent studies have shown that adipose tissue may be the direct target of vitamin D physiological actions.It has been proved that vitamin D can affect obesity through numerous mechanisms, including protein expression, oxidative stress, inflammation and cellular metabolism. Currently, recommendations for treatment and prevention of vitamin D deficiency can be found in international foreign guidebooks whose authors state that obese children need a higher dosage of vitamin D compared to those whose physical development is consistent with age. Understanding the influence of adipose mass on bone tissue during its growth and development is a very important aspect for further health and pharmacotherapy strategies to prevent bone disorders.