segmental allergen challenge
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2016 ◽  
Vol 138 (2) ◽  
pp. 596-599.e4 ◽  
Author(s):  
Marina Miller ◽  
Stephane Esnault ◽  
Richard C. Kurten ◽  
Elizabeth A. Kelly ◽  
Andrew Beppu ◽  
...  

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0143976
Author(s):  
Vanessa J. Kelly ◽  
Tilo Winkler ◽  
Jose G. Venegas ◽  
Mamary Kone ◽  
Daniel L. Hamilos ◽  
...  

Thorax ◽  
2015 ◽  
Vol 71 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Chris Carlsten ◽  
Anders Blomberg ◽  
Mandy Pui ◽  
Thomas Sandstrom ◽  
Sze Wing Wong ◽  
...  

RationaleTraffic-related air pollution has been shown to augment allergy and airway disease. However, the enhancement of allergenic effects by diesel exhaust in particular is unproven in vivo in the human lung, and underlying details of this apparent synergy are poorly understood.ObjectiveTo test the hypothesis that a 2 h inhalation of diesel exhaust augments lower airway inflammation and immune cell activation following segmental allergen challenge in atopic subjects.Methods18 blinded atopic volunteers were exposed to filtered air or 300 µg PM2.5/m3 of diesel exhaust in random fashion. 1 h post-exposure, diluent-controlled segmental allergen challenge was performed; 2 days later, samples from the challenged segments were obtained by bronchoscopic lavage. Samples were analysed for markers and modifiers of allergic inflammation (eosinophils, Th2 cytokines) and adaptive immune cell activation. Mixed effects models with ordinal contrasts compared effects of single and combined exposures on these end points.ResultsDiesel exhaust augmented the allergen-induced increase in airway eosinophils, interleukin 5 (IL-5) and eosinophil cationic protein (ECP) and the GSTT1 null genotype was significantly associated with the augmented IL-5 response. Diesel exhaust alone also augmented markers of non-allergic inflammation and monocyte chemotactic protein (MCP)-1 and suppressed activity of macrophages and myeloid dendritic cells.ConclusionInhalation of diesel exhaust at environmentally relevant concentrations augments allergen-induced allergic inflammation in the lower airways of atopic individuals and the GSTT1 genotype enhances this response. Allergic individuals are a susceptible population to the deleterious airway effects of diesel exhaust.Trial registration numberNCT01792232.


Radiology ◽  
2015 ◽  
Vol 274 (1) ◽  
pp. 267-275 ◽  
Author(s):  
Julius Renne ◽  
Jan Hinrichs ◽  
Christian Schönfeld ◽  
Marcel Gutberlet ◽  
Carla Winkler ◽  
...  

2014 ◽  
Vol 21 (8) ◽  
pp. 994-1001
Author(s):  
Jan Hinrichs ◽  
Frank Schaumann ◽  
Julius Renne ◽  
Christian Schönfeld ◽  
Cornelia Faulenbach ◽  
...  

2014 ◽  
Vol 85 (7) ◽  
pp. 580-587 ◽  
Author(s):  
Dorothea Dijkstra ◽  
Christian Hennig ◽  
Gesine Hansen ◽  
Heike Biller ◽  
Norbert Krug ◽  
...  

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