Switch Elements with S-Shaped Current-Voltage Characteristic in Models of Neural Oscillators

In this paper, we present circuit solutions based on a switch element with the S-type I–V characteristic implemented using the classic FitzHugh–Nagumo and FitzHugh–Rinzel models. Using the proposed simplified electrical circuits allows the modeling of the integrate-and-fire neuron and burst oscillation modes with the emulation of the mammalian cold receptor patterns. The circuits were studied using the experimental I–V characteristic of an NbO2 switch with a stable section of negative differential resistance (NDR) and a VO2 switch with an unstable NDR, considering the temperature dependences of the threshold characteristics. The results are relevant for modern neuroelectronics and have practical significance for the introduction of the neurodynamic models in circuit design and the brain–machine interface. The proposed systems of differential equations with the piecewise linear approximation of the S-type I–V characteristic may be of scientific interest for further analytical and numerical research and development of neural networks with artificial intelligence.

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

It has been proposed that one of the mechanisms of taxane-site ligand-mediated tubulin activation is modulation of the structure of a switch element (the M-loop) from a disordered form in dimeric tubulin to a folded helical structure in microtubules. Here, we used covalent taxane-site ligands, including cyclostreptin, to gain further insight into this mechanism. The crystal structure of cyclostreptin-bound tubulin reveals covalent binding to βHis229, but no stabilization of the M-loop. The capacity of cyclostreptin to induce microtubule assembly compared to other covalent taxane-site agents demonstrates that the induction of tubulin assembly is not strictly dependent on M-loop stabilization. We further demonstrate that most covalent taxane-site ligands are able to partially overcome drug resistance mediated by βIII-tubulin (βIII) overexpression in HeLa cells, and compare their activities to pironetin, an interfacial covalent inhibitor of tubulin assembly that displays invariant growth inhibition in these cells. Our findings suggest a relationship between a diminished interaction of taxane-site ligands with βIII-tubulin and βIII tubulin-mediated drug resistance. This supports the idea that overexpression of βIII increases microtubule dynamicity by counteracting the enhanced microtubule stability promoted by covalent taxane-site binding ligands.

Cross-Point Comparison of Multistage Non-Blocking Technologies

Multistage switching networks play important role in communication and computer network. They make communication nodes connect to each other. In computer hardware switches connect processors and memories. Initially, switches are arranged as one stage interconnection. As clients are growing, multistage is a must. The finding Clos multistage switching initiated multistage technologies. Benes improves Clos by reducing number of cross-points by using a 2 x 2 switch element and call re-routing. Batcher improves the technology by other way which is sorting destination address. Banyan is then joined to Batcher to simplify routing control. This paper analyses the number of cross-point required in Clos, Benes and Batcher Banyan to accomplish multistage switching architecture of 16, 64, 256, 1024 and 2048 input/output ports. As results, Clos cross-point is in averages 495.24% higher than Benes and 160.30% higher than Batcher Banyan. Clos blocking probabilities are closed to zero. Benes blocking probabilities are conditionally zero. Batcher Banyan blocking probabilities are zero.

Vision-based navigation using multi-rate feedback from optic flow and scene reconstruction

Vision-based control is being aggressively pursued for autonomous systems. Such control is particularly valuable for path planning to achieve mission objectives like target tracking and obstacle avoidance. This paper presents a multi-rate strategy that utilises a fast-rate optic flow approach and a slow-rate scene reconstruction approach. The vehicle uses scene reconstruction to generate an accurate map for path planning; however, optic flow is used to avoid obstacles while the scene reconstruction is computed. A switch element is used in the feedback path to determine whether information relating to the reconstructed map or the optical flow should be used for navigation. The resulting controller is able to generate flight trajectories and perform obstacle avoidance within a computational cost which is reasonable given performance demands and computational resources on a wide range of aircraft. A simulation demonstrates the performance of an aircraft that uses the multi-rate controller to avoid an obstacle which is only observed after a turn. Essentially, the fast-rate optic flow indicates the presence of the obstacle during the time that slow-rate scene reconstruction is being performed. The resulting flight path is able to follow mission objectives and avoid a collision.