dimeric bisbenzimidazoles
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DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties; genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n)

2020 ◽  
Vol 28 (7) ◽  
pp. 115378
Author(s):  
Vasiliy S. Koval ◽  
Albert F. Arutyunyan ◽  
Victor I. Salyanov ◽  
Alexey A. Kostyukov ◽  
Olga E. Melkina ◽  
...  
Keyword(s):  
Dna Sequence ◽  
Chemical Properties ◽  
Physico Chemical ◽  
Biochemical Studies ◽  
Dimeric Bisbenzimidazoles

Effects of Dimeric Bisbenzimidazoles and Ionizing Radiation on MCF-7 Breast Cancer Stem Cells

BIOPHYSICS ◽  
2020 ◽  
Vol 65 (1) ◽  
pp. 74-81
Author(s):  
K. A. Churyukina ◽  
A. L. Zhuze ◽  
A. A. Ivanov ◽  
I. A. Zamulaeva
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Ionizing Radiation ◽  
Breast Cancer Stem Cells ◽  
Dimeric Bisbenzimidazoles ◽  
Mcf 7

scholarly journals Dimeric bisbenzimidazoles DB(n) in combination with ionizing radiation decrease number and clonogenic activity of MCF-7 breast cancer stem cells

2020 ◽  
Vol 7 (4) ◽  
pp. 339-361
Author(s):  
Irina A. Zamulaeva ◽  
◽  
Kristina A. Churyukina ◽  
Olga N. Matchuk ◽  
Alexander A. Ivanov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Ionizing Radiation ◽  
Breast Cancer Stem Cells ◽  
Dimeric Bisbenzimidazoles ◽  
Mcf 7

DNA sequence-specific ligands. XVII. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric bisbenzimidazoles DBA(n)

2018 ◽  
Vol 26 (9) ◽  
pp. 2302-2309 ◽  
Author(s):  
Vasiliy S. Koval ◽  
Albert F. Arutyunyan ◽  
Victor L. Salyanov ◽  
Regina R. Klimova ◽  
Alla A. Kushch ◽  
...  
Keyword(s):  
Dna Sequence ◽  
Spectral Properties ◽  
Biochemical Studies ◽  
Dimeric Bisbenzimidazoles

DNA sequence-specific dimeric bisbenzimidazoles DBP(n) and DBPA(n) as inhibitors of H-NS silencing in bacterial cells

2018 ◽  
Vol 207 ◽  
pp. 75-82 ◽  
Author(s):  
Olga E. Melkina ◽  
Vasilii S. Koval ◽  
Alexander A. Ivanov ◽  
Alexei L. Zhuze ◽  
Gennadii B. Zavilgelsky
Keyword(s):  
Dna Sequence ◽  
Bacterial Cells ◽  
Dimeric Bisbenzimidazoles

scholarly journals Symmetric dimeric bisbenzimidazoles DBP(n) reduce methylation of RARB and PTEN while significantly increase methylation of rRNA genes in MCF-7 cancer cells

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0189826 ◽  
Author(s):  
Svetlana V. Kostyuk ◽  
Margarita A. Kvasha ◽  
Daria A. Khrabrova ◽  
Olga V. Kirsanova ◽  
Elizaveta S. Ershova ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Rrna Genes ◽  
Dimeric Bisbenzimidazoles ◽  
Mcf 7

scholarly journals Erratum to: “DNA sequence-specific ligands: XVI. Series of the DBP(n) fluorescent dimeric bisbenzimidazoles with 1,4-piperazine-containing linkers”

2017 ◽  
Vol 43 (6) ◽  
pp. 690-690
Author(s):  
V. S. Koval ◽  
A. A. Ivanov ◽  
V. I. Salyanov ◽  
A. A. Stomakhin ◽  
V. A. Oleinikov ◽  
...  
Keyword(s):  
Dna Sequence ◽  
Dimeric Bisbenzimidazoles

scholarly journals DIMERIC BISBENZIMIDAZOLES SUPPRESS THE HERPES SIMPLEX VIRUS AND HUMAN CYTOMEGALOVIRUS INFECTIONS IN CELL СULTURES

2017 ◽  
Vol 62 (4) ◽  
pp. 162-168 ◽  
Author(s):  
R. R. Klimova ◽  
E. D. Momotyuk ◽  
N. A. Demidova ◽  
Ya. Yu. Chernoryzh ◽  
V. S. Koval ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Antiviral Activity ◽  
Human Cytomegalovirus ◽  
Active Agent ◽  
Therapeutic Effects ◽  
Test Models ◽  
Dimeric Bisbenzimidazoles ◽  
Simplex Virus

Antiviral activity of new AТ-specific fluorescent symmetric dimeric bisbenzimidazoles of DBА(n) series was assessed in the cell models of infections caused by type 1 herpes simplex virus (HSV1) and human cytomegalovirus (CMV). In DBA(n) molecules bisbenzimidazole fragments are bound to an oligomethylene liner with varied number of methylene groups in the linker (n = 1, 3, 5, 7, 9, 11). In contrast to DB(n) dimeric bisbenzimidazoles, in DBA(n) series terminal fragments of macromolecules contain N-dimethylaminopropylcarboxamide groups instead of N-methylpiperazine groups. DBА(n) compounds better dissolve in water, pass across plasma and nuclear membrane, and stain DNA in living cells. DBA(1) and DBA(7) produced therapeutic effects in HSV1 infection; DBA(7) completely suppressed the infection. DBA(11) displayed in vitro therapeutic activity in HSV1 and CMV infections. In addition, DBA(7) and DBA(1) showed microbicidal activity. Thus, DBA(11), which is active against two viruses causing severe diseases with serious health consequences for immunodeficient individuals, should be further investigated. High antiviral activity of DBA(7) in all test models indicates that this compound is a promising active agent for innovative antiviral drugs.

DNA sequence-specific ligands: XVI. Series of the DBP(n) fluorescent dimeric bisbenzimidazoles with 1,4-piperazine-containing linkers

2017 ◽  
Vol 43 (2) ◽  
pp. 143-149 ◽  
Author(s):  
V. S. Koval ◽  
A. A. Ivanov ◽  
V. I. Salyanov ◽  
A. A. Stomakhin ◽  
V. A. Oleinikov ◽  
...  
Keyword(s):  
Dna Sequence ◽  
Dimeric Bisbenzimidazoles
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