intrathecal transplantation
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scholarly journals Lumbar spine intrathecal transplantation of neural precursor cells promotes oligodendrocyte proliferation in hot spots of chronic demyelination

2021 ◽  
Author(s):  
Paschalis Theotokis ◽  
Evangelia Kesidou ◽  
Dimitra Mitsiadou ◽  
Steven Petratos ◽  
Olympia Damianidou ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Hot Spots ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Intrathecal Transplantation

scholarly journals Intrathecal Transplantation of Autologous and Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Dogs

2021 ◽  
Vol 30 ◽  
pp. 096368972110344
Author(s):  
Felipe Pérez Benavides ◽  
Giovana Boff Araujo Pinto ◽  
Marta Cristina Thomas Heckler ◽  
Diana Milena Rodríguez Hurtado ◽  
Livia Ramos Teixeira ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Treatment Success ◽  
Control Group ◽  
Allogeneic Bone ◽  
Marrow Mesenchymal Stem Cells ◽  
Intrathecal Transplantation ◽  
Healthy Dogs ◽  
Magnetic Resonance Imaging Mri

The route used in the transplantation of mesenchymal stem cells (MSCs) can directly affect the treatment success. The transplantation of MSCs via the intrathecal (IT) route can be an important therapeutic strategy for neurological disorders. The objective of this study was to evaluate the safety and feasibility of the IT transplantation of autologous (Auto-MSCs) and allogeneic (Allo-MSCs) bone marrow mesenchymal stem cells (BM-MSCs) in healthy dogs. Based on neurodisability score, cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI), no significant differences from the control group were observed on day 1 or day 5 after IT Auto- or Allo-MSCs transplantation ( P > 0.05). In addition, analysis of matrix metalloproteinase (MMP)-2 and MMP-9 expression in the CSF revealed no significant differences ( P > 0.05) at 5 days after IT transplantation in the Auto- or Allo-MSCs group when compared to the control. Intrathecal transplantation of BM-MSCs in dogs provides a safe, easy and minimally invasive route for the use of cell-based therapeutics in central nervous system diseases.

Intrathecal transplantation of Wharton’s jelly mesenchymal stem cells suppresses the NLRP1 inflammasome in the rat model of spinal cord injury

2019 ◽  
Vol 97 ◽  
pp. 1-8 ◽  
Author(s):  
Yousef Mohamadi ◽  
Seyed Mohammad Hossein Noori Moghahi ◽  
Mahboubeh Mousavi ◽  
Maryam Borhani-Haghighi ◽  
Farid Abolhassani ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Wharton’S Jelly ◽  
Wharton's Jelly ◽  
Nlrp1 Inflammasome ◽  
Cord Injury ◽  
Intrathecal Transplantation

scholarly journals In Vitro Assessment of Fluorine Nanoemulsion-Labeled Hyaluronan-Based Hydrogels for Precise Intrathecal Transplantation of Glial-Restricted Precursors

2019 ◽  
Vol 21 (6) ◽  
pp. 1071-1078 ◽  
Author(s):  
Marcin Piejko ◽  
Piotr Walczak ◽  
Xiaowei Li ◽  
Jeff W. M. Bulte ◽  
Miroslaw Janowski
Keyword(s):  
Intrathecal Transplantation ◽  
In Vitro Assessment

scholarly journals MRI-guided intrathecal transplantation of hydrogel-embedded glial progenitors in large animals

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Izabela Malysz-Cymborska ◽  
Dominika Golubczyk ◽  
Lukasz Kalkowski ◽  
Adam Burczyk ◽  
Miroslaw Janowski ◽  
...  
Keyword(s):  
Glial Progenitors ◽  
Intrathecal Transplantation ◽  
Mri Guided ◽  
Large Animals
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