Synthesis, characterization, solubilization, cytotoxicity and antioxidant activity of aminomethylated dihydroquercetin

We successfully synthesised an efficient, water-soluble, nontoxic, and high antioxidant activity dihydroquercetin derivative (DHQA) by aminomethylation reaction.

Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation

The one-pot [3 + 2] cycloaddition of an azomethine ylide with a maleimide followed by another [3 + 2] cycloaddition of an azide with the second maleimide gives a 1,5-diamino intermediate which is used for a sequential aminomethylation reaction with formaldehyde through [5 + 1] annulation to afford a novel polycyclic scaffold bearing tetrahydroquinazoline, pyrrolidine, pyrrolidinedione, and N-substituted maleimide in stereoselective fashion.

Polymer-Analogous Transformations in Triblock Copolymers Containing Polyacrylamide and Poly(ethylene oxide)

The polymer-analogous conversion of triblock copolymers (TBC) PAAm-b-PEO-b-PAAm by the aminomethylation reaction in PAAm blocks under the effect of dimethylamine and formaldehyde (Mannich’s reaction) was studied. Kinetic investigations of the Mannich’s reaction in TBC as compared to that in pure PAAm were performed by potentiometric titration. The existence of two competitive polymer-analogous transformations in PAAm chains of all the (co)polymers such as aminomethylation and alkaline hydrolysis of amide groups was established and discussed.