The present work aims to simulate and predict the molecular pathway of Parkinson’s disease (PD) initiated by environmental stress. It is designed to predict how protein aggregation and Lewy body (LB) formation leads to dopamine toxicity finally leading to cell death. The Mechanistic electronic modeling using Digital-Analog hybrid technique has been designed and implemented using MULTISIM 8.0 (National Instruments, USA) to simulate and predict the dynamics of PD pathway under environmental stress condition. The electronic network is initiated through an analog comparator circuit that compares the long-term environmental alterations with the cellular set point level of the molecular kinetics. The pattern of neuronal firing is simulated with the help of analog electronic circuit. The simulation results show a slow progressive rise in [Formula: see text]-synuclein/LB/dopamine toxicity level within the neuronal cells, which is comparable to published experimental and modeling studies associated with PD. Finally, cell death is demonstrated, which leads to neurodegeneration. In conclusion, our model allows a straightforward implementation of qualitative representation for systems where the network topology or pathway is at least moderately known.
Piezoelectric energy harvesting from colored fat-tailed fluctuations: An electronic analogy