TWO-LEAD JOINT DETECTION ALGORITHM OF QRS COMPLEXES IN ECG SIGNAL

Objective: The detection of QRS complexes is an important part of computer-aided analysis of electrocardiogram (ECG). However, most of the existing detection algorithms are mainly for single-lead ECG signals, which requires high quality of signal. If the signal quality decreases suddenly due to some interference, then the current algorithm is easy to cause misjudgment or missed detection. To improve the detection ability of QRS complexes under sudden interference, we study the QRS complexes information on multiple leads in-depth, and propose a two-lead joint detection algorithm of QRS complexes. Methods: Firstly, the suspected QRS complexes are screened on the main lead. For the suspected QRS complexes with low confidence and the complexes that may be missed, further accurate detection and joint judgment shall be carried out at the corresponding position of the auxiliary lead. At the same time, the adaptive threshold adjustment algorithm and backtracking mechanism are used to modify the detection results. Results: The proposed detection algorithm is validated using 48 ECG records of the MIT-BIH arrhythmia database, and achieves average detection accuracy of 99.71%, sensitivity of 99.88% and positive predictivity of 99.81%. Conclusion: The proposed algorithm has high accuracy, which can effectively deal with the sudden interference of ECG signal. Meanwhile, the algorithm requires small amount of computation, and can be embedded into hardware for real-time detection.

Bayesian approach to discriminant problems for count data with application to multilocus short tandem repeat dataset

Short Tandem Repeats (STRs) are a type of DNA polymorphism. This study considers discriminant analysis to determine the population of test individuals using an STR database containing the lengths of STRs observed at more than one locus. The discriminant method based on the Bayes factor is discussed and an improved method is proposed. The main issues are to develop a method that is relatively robust to sample size imbalance, identify a procedure to select loci, and treat the parameter in the prior distribution. A previous study achieved a classification accuracy of 0.748 for the g-mean (geometric mean of classification accuracies for two populations) and 0.867 for the AUC (area under the receiver operating characteristic curve). We improve the maximum values for the g-mean to 0.830 and the AUC to 0.935. Computer simulations indicate that the previous method is susceptible to sample size imbalance, whereas the proposed method is more robust while achieving almost identical classification accuracy. Furthermore, the results confirm that threshold adjustment is an effective countermeasure to sample size imbalance.