Membrane fouling amelioration through pseudo dead-end filtration coupled with transmembrane pressure (TMP) set-point control in an anaerobic membrane bioreactor for municipal wastewater treatment

Sustainable membrane operation in an AnMBR achieved under pseudo dead-end filtration coupled with TMP set-point control with a low energy demand and operational cost, promoting energy neutral sewage treatment to be realized.

Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1

To better understand telomere length set point control in human stem cells, we generated knockout stem cell lines for TPP1 and contrasted their phenotypes with those of homozygous TPP1 L104A mutant stem cells. This comparison reveals that TPP1 L104A is not a hypomorphic allele but formally establishes TPP1 L104 as a dissociation of function mutant.

Multi-Loop Model Reference Proportional Integral Derivative Controls: Design and Performance Evaluations

Due to unpredictable and fluctuating conditions in real-world control system applications, disturbance rejection is a substantial factor in robust control performance. The inherent disturbance rejection capacity of classical closed loop control systems is limited, and an increase in disturbance rejection performance of single-loop control systems affects the set-point control performance. Multi-loop control structures, which involve model reference control loops, can enhance the inherent disturbance rejection capacity of classical control loops without degrading set-point control performance; while the classical closed Proportional Integral Derivative (PID) control loop deals with stability and set-point control, the additional model reference control loop performs disturbance rejection control. This adaptive disturbance rejection, which does not influence set-point control performance, is achieved by selecting reference models as transfer functions of real control systems. This study investigates six types of multi-loop model reference (ML-MR) control structures for PID control loops and presents straightforward design schemes to enhance the disturbance rejection control performance of existing PID control loops. For this purpose, linear and non-linear ML-MR control structures are introduced, and their control performance improvements and certain inherent drawbacks of these structures are discussed. Design examples demonstrate the benefits of the ML-MR control structures for disturbance rejection performance improvement of PID control loops without severely deteriorating their set-point performance.

Set-Point Control of a Musculoskeletal System Under Gravity by a Combination of Feed-Forward and Feedback Manners Considering Output Limitation of Muscular Forces

This paper proposes a new control method for musculoskeletal systems, which combines a feed-forward input with a feedback input, while considering an output limit. Our previous research proposed a set-point control that used a complementary combination of feedback using a time delay and a muscular internal force feed-forward; it achieved robust and rapid positioning with relatively low muscular contraction forces. However, in that control method, the range of motion of the musculoskeletal system was limited within a horizontal plane. In other words, that system did not consider the effect of gravity. The controller proposed in this paper can achieve the reaching movement of the musculoskeletal system without requiring accurate physical parameters under gravity. Moreover, the input of the proposed method can be prevented from becoming saturated with the output limit. This paper describes the design of the proposed controller and demonstrates the effectiveness of the proposed method based on the results of numerical simulations.

Behavioural Fault tolerant control of an Omni directional Mobile Robot with Four mecanum Wheels

This paper analyses the four-mecanum wheeled drive mobile robot wheels configurations that will give near desired performance with one fault and two faults for both set-point control and trajectory-tracking (circular profile) using kinematic motion control scheme within the tolerance limit. For one fault the system remains in its full actuation capabilities and gives the desired performance with the same control scheme. In case of two-fault wheels all combinations of faulty wheels have been considered using the same control scheme. Some configurations give desired performance within the tolerance limit defined while some does not even use pseudo inverse since using the system becomes under-actuated and their wheel alignment and configurations greatly influenced the performance.