Hydrogen sulfide (H2S) - therapeutic relevance in rehabilitation and balneotherapy Systematic literature review and meta-analysis based on the PRISMA paradig

Background. An active molecule in sulfurous mineral - therapeutic waters and also in sapropelic mud is H2S, a hormetic gaseous molecule that can actively penetrate the skin. While high levels of H2S are extremely toxic, low levels are tolerated and have potential cytoprotective effects, with anti-inflammatory and antioxidant applications. Objective. This systematic review aims to rigorously select related articles and identify within their content the main possible uses of hydrogen sulfide from balneary sources and to explain its physiological mechanisms and therapeutic properties. Methods. To elaborate our systematic review, we have searched for relevant open access articles in 6 international databases: Cochrane , Elsevier , NCBI/PubMed , NCBI/PMC , PEDro , and ISI Web of Knowledge/Science , published from January 2016 until July 2021. The contextually quested keywords combinations/ syntaxes used are specified on this page. The eligible articles were analyzed in detail regarding pathologies addressed by hydrogen sulfide. All articles with any design (reviews, randomized controlled trials, non-randomized controlled trials, case-control studies, cross-sectional studies), if eligible according to the above-mentioned selection methodology, containing in the title the selected combinations, were included in the analysis. Articles were excluded in the second phase if they did not reach the relevance criterion. Results. Our search identified, first, 291 articles. After eliminating the duplicates and non-ISI articles, remained 121 papers. In the second phase, we applied a PEDro selection filter, resulting in 108 articles that passed the relevance criterion and were included in this systematic review. Conclusions. H2S biology and medical relevance are not fully understood and used adequately for sanogenic or medical purposes. More research is needed to fully understand the mechanisms and importance of this therapeutic gase. The link between balneotherapy and medical rehabilitation regarding the usage of hydrogen sulfide emphasises the unity for this medical speciality.

Therapeutic gases used in balneotherapy and rehabilitation medicine - scientific relevance in the last ten years (2011 – 2020) - Synthetic literature review

ABSTRACT: Background. The medical relevance of therapeutic gases can range from use in burns and stroke victims to hypoxia therapy in children. However, medical gases such as oxygen, hydrogen, helium and xenon have recently come under increased exploration for their potential therapeutic use on various brain disease states, including traumatic brain injuries, hypoxia-ischemia and, cerebral hemorrhages. Objective. This synthetic review aims to rigorously select related articles and identify within their content the main possible uses of therapeutic gases and physiological mechanisms. The objective of this article is to present the various therapeutic mechanisms that have been proposed in the current literature and the medical relevance of various therapeutic gases used in balneotherapy or medical rehabilitation. Methods. To elaborate our synthesis review, we have searched for relevant open access articles in 6 international databases: Cochrane, Elsevier, NCBI/PubMed, NCBI/PMC, PEDro, and ISI Web of Knowledge/Science, published from January 2011 until December 2020. The contextually quested keywords combinations/ syntaxes used specified on this page. The eligible articles were analyzed in detail regarding pathologies addressed by therapeutic gases. All articles with any design (reviews, randomized controlled trials, non-randomized controlled trials, case-control studies, cross-sectional studies), if eligible according to the above-mentioned selection methodology, containing in the title or abstract the above-mentioned combinations, were included in the analysis. Articles were excluded in the second phase if they did not reach the relevance criterion. Results. Our search identified, first, 225 articles. After eliminating the duplicates, remained 180 articles. In the second phase, we applied a relevance criterion. Although our team - including the authors of this paper – have quite long and consistent expertise in achieving systematic literature reviews, the marked heterogeneity of both the item composing the subject we have approached and inherently the wase of presentations in the respective quite vast and diverse domain of medical gases, prevented us to fulfil, at least regarding this initial work, a systematic literature review. Instead, we succeeded to make a hopefully interesting and valuable narrative synthetic-related literature review. At the end of the second phase, 63 articles passed the relevance criterion and were included in this synthetic review. Conclusions. Therapeutic gases are not fully understood and used adequately for sanogenic or medical purposes. More research is needed to fully understand the mechanisms and importance of therapeutic gases. The link between balneotherapy and medical rehabilitation regarding the usage of therapeutical gases emphasises the unity for this medical speciality. Keywords: "Therapeutic gas"/ "Oxygen therapy"/ "Carbon dioxide"/ "CO2 therapy"/ "Carbon monoxide"/ "Mofette"/ "Hydrogen Sulfide"/ "H2S"/ "Helium"/ "Xenon"/ "Ozone therapy"/ "Radon"/ "Hydrogen therapy"/ "Nitric oxide"/ "Heliox" AND "Rehabilitation".

Efficient Access of Data Resources in Cloud

An attempt towards developing time efficient cloud computing architecture, by considering the deficiencies with respect to existing clouds, better ontology-based cloud information architecture is proposed in this thesis. In this architecture, additional modules on query retrieval and query refinement are added for better performance. Rocchio technique is used for query refinement to extract results with respect to relevance criterion is adopted. The proposed architecture gives better-indexed results after transforming the user query. Further, the cloud customers are provided with a flexible, scalable and pay per use services via many cloud vendors, security becomes a major issue. Hence, the article also proposes an alternate authentication technique for generating password at client end towards secured data access from cloud and it also prevents third party from accessing data at client side.

Gravizor

Users of Web search engines are generally confronted to numerous responses that are rarely structured, making it difficult to analyze the available results. Indeed, the linear results displayed through lists ordered according to a relevance criterion, although still widely used, seem often limitless. A solution to this problem is to improve the interfaces for better visualization of large number of results. In this paper, we propose modeling and implementation of a tool for graphical visualization and manipulation of results returned by search engines. The goal is to facilitate the analysis, the interpretation and the supervision of users' information needs. The architecture of the ‘Gravisor' tool is based on Multi-Agent paradigm. It is composed of four agents working in full cooperation and coordination. We hope that besides the web information retrieval field, the three graphical visualization modes offered by the ‘Gravisor' tool will be a promising alternative for better information visualization in other areas.

Gravizor

Users of Web search engines are generally confronted to numerous responses that are rarely structured, making it difficult to analyze the available results. Indeed, the linear results displayed through lists ordered according to a relevance criterion, although still widely used, seem often limitless. A solution to this problem is to improve the interfaces for better visualization of large number of results. In this paper, we propose modeling and implementation of a tool for graphical visualization and manipulation of results returned by search engines. The goal is to facilitate the analysis, the interpretation and the supervision of users' information needs. The architecture of the ‘Gravisor' tool is based on Multi-Agent paradigm. It is composed of four agents working in full cooperation and coordination. We hope that besides the web information retrieval field, the three graphical visualization modes offered by the ‘Gravisor' tool will be a promising alternative for better information visualization in other areas.