Synthesis and Properties of Biodegradable Copolymers Based on ε-Caprolactam and α-Angelicalactone

Copolymers and block-copolymers of ε-caprolactam, α-angelicalactone and polyangelicalactone were first synthesized by the anionic polymerization method. Yields of polymers and rates of their formation decrease with increasing the α-angelicalactone and polyangelicalactone concentration. Physical and mechanical properties of the obtained copolymers are very close to the properties of polycaprolactam. The synthesized block-copolymers are biodegradable in the grey forest soil, and they are completely visually destroyed during 20 weeks. The water extracts of the biodegradation products are nontoxic

A facile method to synthesize bio-based and biodegradable copolymers from furandicarboxylic acid and isosorbide with high molecular weights and excellent thermal and mechanical properties

Biobased, biodegradable copolymers containing isosorbide and 2,5-furandicarboxylic acid with high performance are successfully synthesized through a non-solvent and economical pathway.

Preparation and Characterization of Copolymeric Polymersomes for Protein Delivery

Biodegradable copolymeric polymersomes have been used for controlled drug delivery of proteins. These polymersomes important areas to overcome formulation associated problems of the proteins. The aim of this study was to develop polymersomes using biodegradable copolymers for delivery of bovine serum albumin (BSA) as a model protein. Encapsulated BSA by mPEG-PCL polymersomes led to formation of BSA-loaded mPEG-PCL polymersomes. The polymersomes synthesized with the protein-polymer ratio of 1:4 at 15 000 rpm gave maximum loading, minimum polydispersion with maximally sustained protein release pattern, among the prepared polymersomes. Investigation on FTIR and DSC results revealed that such a high encapsulation efficiency is due to strong interaction between BSA and the copolymer.The particles size and their morphology of polymersomes were determined by DLS and AFM.The encapsulation efficiency of BSA was 91.02%. The results of AFM showed that the polymersomes had spherical shapes with size of 49 nm.The sizes of BSA-loaded polymersomes ranged from 66.06 nm to 84.97 nm. The results showed that polymersomes exhibited a triphasic release, for BSA. Overall, the results indicated that mPEG–PCL polymersomes can be considered as a promising carrier for proteins.

Polycarbonate-based biodegradable copolymers for stimuli responsive targeted drug delivery

The newly developed polymeric nanocarrier could open a new avenue for cancer therapy, due to its unique design as well as, most importantly, its biocompatible and biodegradable nature.