thalamocortical projection
Recently Published Documents


TOTAL DOCUMENTS

50
(FIVE YEARS 1)

H-INDEX

20
(FIVE YEARS 0)

Author(s):  
Barbara J. Hunnicutt ◽  
Brian R. Long ◽  
Deniz Kusefoglu ◽  
Katrina J. Gertz ◽  
Haining Zhong ◽  
...  

2019 ◽  
Author(s):  
Idoia Quintana-Urzainqui ◽  
P Pablo Hernández-Malmierca ◽  
James M. Clegg ◽  
Ziwen Li ◽  
Zrinko Kozić ◽  
...  

AbstractThalamocortical axons (TCAs) cross several tissues on their journey to the cortex. Mechanisms must be in place along the route to ensure they connect with their targets in an orderly fashion. The ventral telencephalon acts as an instructive tissue, but the importance of the diencephalon in TCA mapping is unknown. We report that disruption of diencephalic development by Pax6 deletion results in a thalamocortical projection containing mapping errors. We used conditional mutagenesis to test whether these errors are due to the disruption of pioneer projections from prethalamus to thalamus and found that, while this correlates with abnormal TCA fasciculation, it does not induce topographical errors. To test whether the thalamus contains navigational cues for TCAs, we used slice culture transplants and gene expression studies. We found the thalamic environment is instructive for TCA navigation and that the molecular cues Netrin1 and Semaphorin3a are likely to be involved. Our findings indicate that the correct topographic mapping of TCAs onto the cortex requires the order to be established from the earliest stages of their growth by molecular cues in the thalamus itself.


2017 ◽  
Vol 637 ◽  
pp. 26-30 ◽  
Author(s):  
Hiroaki Tsukano ◽  
Masao Horie ◽  
Kuniyuki Takahashi ◽  
Ryuichi Hishida ◽  
Hirohide Takebayashi ◽  
...  

2014 ◽  
Vol 17 (9) ◽  
pp. 1276-1285 ◽  
Author(s):  
Barbara J Hunnicutt ◽  
Brian R Long ◽  
Deniz Kusefoglu ◽  
Katrina J Gertz ◽  
Haining Zhong ◽  
...  

Development ◽  
2014 ◽  
Vol 141 (10) ◽  
pp. 2075-2084 ◽  
Author(s):  
K. Ono ◽  
A. Clavairoly ◽  
T. Nomura ◽  
H. Gotoh ◽  
A. Uno ◽  
...  

2010 ◽  
Vol 20 (10) ◽  
pp. 2277-2286 ◽  
Author(s):  
Hanno S. Meyer ◽  
Verena C. Wimmer ◽  
M. Oberlaender ◽  
Christiaan P.J. de Kock ◽  
Bert Sakmann ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document