Unilateral Renal Cystic Disease: A Case Report and Literature Review

BACKGROUND: URCD is a rare disease characterized by cysts with various sizes in a diffusely enlarged kidney without forming a distinct encapsulated mass. We present literature review and report a case of URCD in our center. The aim of the study was to report a case of unilateral renal cystic disease (URCD) in a 25-year-old female. CASE REPORT: The patient was a 25-year-old female. She came to emergency unit of Mitra Medika Amplas Hospital Medan, Indonesia, with dyspepsia associated symptoms. Physical examination and family health-related history were normal. Laboratory examinations and genetic evaluation showed no abnormalities. Ultrasonography examination revealed multiple cysts in her right kidney which was confirmed by computed tomography (CT) scan. The diagnosis of URCD was confirmed. No specific treatment was given and she was advised to do a routine follow-up. CONCLUSION: URCD may present with mild symptoms or even asymptomatic. Diagnosis is confirmed by imaging modalities with normal renal function and absence of genetic predisposition. The management is conservative. Routine follow-up is mandatory.

Unilateral renal cystic disease: a case report study

Unilateral renal cystic disease (URCD) of kidney is a non-familial, extremely rare condition, characterized by replacement of the renal parenchyma of one kidney by a cluster of multiple cysts of varying size with a normal contralateral kidney. It is morphologically indistinguishable from autosomal dominant polycystic kidney disease (ADPKD); as such, hepatic and pancreatic cysts is not seen and shows no progressive deterioration in renal function; thus, differentiating ADPKD from URCD becomes important. We report a case of URCD documented by clinical and radiological imaging. A 21 year-old female, presented with history of mild lancinating pain in the left flank for 6 years which aggravated in the past 3 days, with no history of lower urinary tract symptoms. No significant family illnesses reported. Examination showed normal vitals and ballotability present and associated tenderness on deep palpation in left lumbar region. Laboratory findings were within normal limits. Ultrasonography of abdomen and pelvis showed left hydronephrosis with multiple cysts. CECT Abdomen revealed an enlarged left kidney (∼15×16×10 cm) filled with variable sized round, well-marginated multiple cysts. Renal ultrasound was performed on patient’s parents and her siblings and ruled out cystic renal disease. Hence, authors considered the diagnosis of URCD in this patient. In conclusion, treatment and managing guidelines of URCD have not been mentioned in any of the medical literatures. There is little information regarding the progression of URCD. Hence there is a need for further understanding of pathogenesis, progression and management of these patients.

Unilateral Renal Cystic Disease (URCD)

DOI: http://dx.doi.org/10.3329/jafmc.v8i1.13541 JAFMC Vol.8(1) 2012 pp.53-55