Assessing the Physiological Relevance of Cough Simulators for Respiratory Droplet Dispersion

Various breathing and cough simulators have been used to model respiratory droplet dispersion and viral droplets, in particular for SARS-CoV-2 modeling. However, limited data are available comparing these cough simulations to physiological breathing and coughing. In this study, three different cough simulators (Teleflex Mucosal Atomization Device Nasal (MAD Nasal), a spray gun, and GloGermTM MIST) that have been used in the literature were studied to assess their physiologic relevance. Droplet size, velocity, dispersion, and force generated by the simulators were measured. Droplet size was measured with scanning electron microscopy (SEM). Slow-motion videography was used to 3D reconstruct and measure the velocity of each simulated cough. A force-sensitive resistor was used to measure the force of each simulated cough. The average size of droplets from each cough simulator was 176 to 220 µm. MAD Nasal, the spray gun, and GloGermTM MIST traveled 0.38 m, 0.89 m, and 1.62 m respectively. The average velocities for the MAD Nasal, spray gun, and GloGermTM MIST were 1.57 m/s, 2.60 m/s, and 9.27 m/s respectively, and all yielded a force of <0.5 Newtons. GloGermTM MIST and the spray gun most closely resemble physiological coughs and breathing respectively. In conclusion, none of the simulators tested accurately modeled all physiologic characteristics (droplet size, 3-D dispersion velocity, and force) of a cough, while there were various strengths and weaknesses of each method. One should take this into account when performing simulations with these devices.

Delivery Strategies for Skin: Comparison of Nanoliter Jets, Needles and Topical Solutions

Drug diffusion within the skin with a needle-free micro-jet injection (NFI) device was compared with two well-established delivery methods: topical application and solid needle injection. A permanent make-up (PMU) machine, normally used for dermal pigmentation, was utilized as a solid needle injection method. For NFIs a continuous wave (CW) laser diode was used to create a bubble inside a microfluidic device containing a light absorbing solution. Each method delivered two different solutions into ex vivo porcine skin. The first solution consisted of a red dye (direct red 81) and rhodamine B in water. The second solution was direct red 81 and rhodamine B in water and glycerol. We measured the diffusion depth, width and surface area of the solutions in all the injected skin samples. The NFI has a higher vertical dispersion velocity of 3 × 105μm/s compared to topical (0.1 μm/s) and needle injection (53 μm/s). The limitations and advantages of each method are discussed, and we conclude that the micro-jet injector represents a fast and minimally invasive injection method, while the solid needle injector causes notable tissue damage. In contrast, the topical method had the slowest diffusion rate but causes no visible damage to the skin.

A Comparison of Drug Delivery into Skin Using Topical Solutions, Needle Injections and Jet Injections

Drug diffusion within the skin with a needle-free micro-jet injection (NFI) device was compared with two well-established delivery methods: topical application and solid needle injection. A permanent make-up (PMU) machine, normally used for dermal pigmentation, was utilized as a solid needle injection method. For NFIs a continuous wave (CW) laser diode was used to create a bubble inside a microfluidic device containing a light absorbing solution. Each method delivered two different solutions intoex-vivoporcine skin. The first solution consisted of a red dye (direct red 81) and rhodamine B in water. The second solution was direct red 81 and rhodamine B in water and glycerol. For PMU experiments, the skin samples were kept stationary and the diffusion depth, width and surface area were measured. The NFI has a higher vertical dispersion velocity of 3 × 105μm/s compared to topical (0.1 μm/s) and needle injection (53μm/s). The limitations and advantages of each method are discussed, and we conclude that the micro-jet injector represents a fast and minimally invasive injection method, while the solid needle injector causes notably tissue damage. In contrast, the topical method had the slowest diffusion rate but causes no visible damage to the skin.

Evaluation and validation of large-eddy simulation sub-grid spray dispersion models using high-fidelity volume-of-fluid simulation data and engine combustion network experimental data

A sub-grid model accounting for the interaction of spray and sub-grid turbulence was developed and tested. The model predicts the sub-grid scale dispersion velocity used for calculating the slip velocity in Lagrangian–Eulerian Large-eddy simulation spray models. The dispersion velocity is assumed to be decomposed into a deterministic and a stochastic part, and it is updated in every turbulence correlation time for each computational parcel. The model was validated against two datasets: volume-of-fluid simulations and Engine Combustion Network experiments. The volume-of-fluid data showed that dispersion velocities at the centerline are anisotropic. This qualitative feature is well captured by the current model. For the Engine Combustion Network Spray A cases, it was found that sub-grid scale dispersion has profound impact on the prediction of the spatial distribution of liquid mass. Neglecting the sub-grid scale dispersion model results in underprediction of the width of the lateral projected liquid mass density profiles. Also, the prediction of the projected liquid mass density is sensitive to the two model constants determining the sub-grid scale dispersion velocity magnitude and turbulence time scale. However, the predictions of resolved gas-phase statistics are relatively insensitive to different sub-grid scale dispersion model setups. The primary reason for this was investigated. It was found that the motion of high-momentum liquid blobs in the near-nozzle region leading to air entrainment and subsequent gas jet development is minimally influenced by sub-grid scale dispersion. The importance of sub-grid scale dispersion inversely correlates with drag force magnitude: the larger the drag force, the less critical the sub-grid scale dispersion. Moving further downstream, quasi-equilibrium between the two phases is established, resulting in relatively small slip velocity and drag force.

Analysis of instability of systems composed by dark and baryonic matter

In this work, the dynamics of self-gravitating systems composed by dark and baryonic matter is analyzed. Searching for a description of this dynamics, a system of collisionless Boltzmann equations for the two constituents and the Poisson equation for the gravitational field are employed. Through the solution of these equations, the collapse criterion is determined from a dispersion relation. The collapse occurs in an unstable region where the solutions grow exponentially with time. It is shown that the unstable region becomes larger if the dispersion velocity of dark matter becomes larger than the one of the baryonic matter. The results obtained are also compared with the case where only the dark matter is present. The model of the present work has a higher limit of instability and therefore exhibited an advantage in the structure formation.

Motion Simulation of Cluster Warhead Based on MATLAB

External trajectory equations of a certain cluster warhead were established according to the analysis of force during the motion process. The distribution on ground and some related motion parameters were got by MATLAB to solve the external trajectory equations. The influence of some factors on the distribution and terminal motion parameters were researched. The results show that the dispersion height and dispersion velocity are the most important factors. This paper can provide some reference for the research on the distribution of cluster warhead and determining operational scheme.

Numerical Study on Dispersion Characteristics and Damage Results of Pre-Fragment Warhead

The dispersion characteristics, damage region and destroy results of typical defending materials by pre-fragment warhead using explosively driven were numerical studied by non-linear finite code of LS-DYNA with fluid-structure interaction algorithm, meanwhile, the influence of different detonation types and explosive properties on dispersion characteristics and damage results of kinetic energy rod were analysed. Results show that: 1.fragments disperse symmetrically with greater damage region when center detonation and line detonate are adopted, and the dispersion velocity of fragments reach the maximum when line detonate is used; 2.explosive of higher detonation velocity in favour of improving the initial velocity of fragments, strengthing the damage ability; 3.the penetration kinetic energy of fragments increase with the decrease of axial angle between fragment and damage target.

Measuring velocity dispersion and attenuation in the exploration seismic frequency band

No perfectly elastic medium exists in the earth. In an anelastic medium, seismic waves are distorted by attenuation and velocity dispersion. Velocity dispersion depends on the petrophysical properties of reservoir rocks, such as porosity, fractures, fluid mobility, and the scale of heterogeneities. However, velocity dispersion usually is neglected in seismic data processing partly because of the insufficiency of observations in the exploration seismic frequency band (∼5 through [Formula: see text]). The feasibility of determining velocity dispersion in this band is investigated. Four methods are used in measuring velocity dispersion from uncorrelated vibrator vertical seismic profile (VSP) data: the moving window crosscorrelation (MWCC) method, instantaneous phase method, time-frequency spectral decomposition method, and cross-spectrum method. The MWCC method is a new method that is satisfactorily robust, accurate, and efficient in measuring the frequency-dependent traveltime in uncorrelated vibrator records. The MWCC method is applied to the uncorrelated vibrator VSP data acquired in the Mallik gas hydrate research well. For the first time, continuous velocity dispersion is observed in the exploration seismic frequency band using uncorrelated vibrator VSP data. The observed velocity dispersion is fitted to a straight line with respect to log frequency to calculate [Formula: see text]. This provides an alternative method for [Formula: see text] measurement.