An Integrative Co-localization (INCO) Analysis for SNV and CNV Genomic Features With an Application to Taiwan Biobank Data

Genomic studies have been a major approach to elucidating disease etiology and to exploring potential targets for treatments of many complex diseases. Statistical analyses in these studies often face the challenges of multiplicity, weak signals, and the nature of dependence among genetic markers. This situation becomes even more complicated when multi-omics data are available. To integrate the data from different platforms, various integrative analyses have been adopted, ranging from the direct union or intersection operation on sets derived from different single-platform analysis to complex hierarchical multi-level models. The former ignores the biological relationship between molecules while the latter can be hard to interpret. We propose in this study an integrative approach that combines both single nucleotide variants (SNVs) and copy number variations (CNVs) in the same genomic unit to co-localize the concurrent effect and to deal with the sparsity due to rare variants. This approach is illustrated with simulation studies to evaluate its performance and is applied to low-density lipoprotein cholesterol and triglyceride measurements from Taiwan Biobank. The results show that the proposed method can more effectively detect the collective effect from both SNVs and CNVs compared to traditional methods. For the biobank analysis, the identified genetic regions including the gene VNN2 could be novel and deserve further investigation.

Collective labor relations and juridification: A marriage proposal

Contributing to debates over relations between the collective and juridified regulation of labor, this article analyzes a rich case study in the Israeli construction sector to claim that juridification can spur unions and employers’ associations to initiate strategic and inclusive change. By subsuming processes of juridification into traditional IR frameworks and embracing its logic and practices, the corporatist social partners broaden the relevance of collective labor relations to workers otherwise excluded from direct union representation. In this way, while not increasing union density or improving wages, these ‘traditional’ IR actors reassert their monopolistic control over worker and employer representation, as well as over the sectoral labor market.

Indwelling without the indwelling Holy Spirit: a critique of Ray Yeo’s modified account

In 2014, Ray Yeo published a modified account of the Spirit’s indwelling in “Towards a Model of the Indwelling: A Conversation with Jonathan Edwards and William Alston.” Yeo utilizes a conglomerate of Two-Minds Christology and Spirit Christology to provide a metaphysical framework for his model which he believes offers a viable alternative to more traditional merger accounts like those of Edwards and Alston. After providing an overview of Yeo’s objections to the merger accounts of Alston and Edwards, I will summarize Yeo’s modified model. I will argue Yeo’s emphasis on the humanity of Christ in lieu of a literal, internal, and direct union of the Holy Spirit and the human person cannot alleviate the core metaphysical concerns which surface in all accounts of union between the divine and human. Yeo’s misunderstanding of Two-Minds Christology leads him to deny the full humanity of Christ; a humanity upon which his entire account of the indwelling relies. Yeo’s modified model will be shown unsuccessful as an account of the indwelling of the Holy Spirit even if one accepts both his conception of Two-Minds Christology and his conditions for indwelling.

Movement strategies ASJ the basis for creating transcendence in the composition of The Tree of Life by Ivana Stefanović

The composition The Tree of Life by Ivana Stefanović, for string orchestra, was written in 1997. It is composed of several entities of similar meaning, which derive from one motif. This fact alone suggests that this composition is essentially a powerful allegory that achieves a complex picture of the birth of human life and its development. The compositional techniques of decorating, superimposing and improvisation are powerful metaphors that indicate the flowering of living wood. From the analytical point of view, the composition by Ivana Stefanović is interesting to observe for it avoids postmodernist procedures. On the contrary, it is like reinterpreting the modernist idea of construction, but tying itself to the transcendent metaphor of life. The aforementioned procedures, which render their perpetual branching to be perceived as a single entity, lead to a complete musical gesture that begins, matures, and ends in transcendence. The common mode of all the procedures used in this piece is the movement that arises from one constant, a pulsation. Musical gestures related to several strategies will be examined in an analytical way. The first is decorating, which is directly related to similar strategies: growing, blooming and improvisation. The binding together of such situations leads to the creation of a unique musical gesture that points to life itself. Such symbolic unity, from the beginning to the end, has been realized in a transcendent mode. In this capacity, the composition The Tree of Life by Ivana Stefanović stands aside from most of the usual stylistic procedures of the time in which it was created. The combination of the strategies used points to a ludic game of linking the pulsation, that is, movements, which stand in direct union with the inexpressible sphere of symbolic, that is, unstoppable eternal currents. The work deals with the analysis of strategies by which motor musical movements, as symbols, at the signifying level, are placed as gestures of expressing the transcendent. Moving lines and their collisions, places for creating prolongation, spreading and shrinking of the texture with the change of its layers, development of motifs with the pronounced application of the variation procedure, all these procedures will be treated as methods of building a unique tree of life. The composer began her narrative network with the basic motif cell, with the first statement, "in the beginning it was [...]". Based on the identification and method of combining the compositional strategies of the movement, it will be possible to prove the thesis of a transcendental musical gesture, formed as a result of the complex interrelations between the individual meaningful units.

On sentences which are true of direct unions of algebras

It is well known that certain sentences corresponding to similar algebras are invariant under direct union; that is, are true of the direct union when true of each factor algebra. An axiomatizable class of similar algebras, such as the class of groups, is closed under direct union when each of its axioms is invariant. In this paper we shall determine a wide class of invariant sentences. We shall also be concerned with determining sentences which are true of a direct union provided they are true of some factor algebra. In the case where all the factor algebras are the same, a further result is obtained. In §2 it will be shown that these criteria are the only ones of their kind. Lemma 7 below may be of some independent interest.We adopt the terminology and notation of McKinsey with the exception that the sign · will be used for conjunction. Expressions of the form ∼∊, where ∊ is an equation, will be called inequalities. In accordance with the analogy between conjunction and disjunction with product and sum respectively, we shall call α1, …, αn the terms of the disjunctionand the factors of the conjunctionEvery closed sentence is equivalent to a sentence in prenez normal form,where x1, …, xm distinct individual variables, Q1, …, Qm are quantifiers, and the matrix S is an open sentence in which each of the variables x1, …, xm actually occurs. The sentence S may be written in either disjunctive normal form:where αi,j is either an equation or an inequality, or in conjunctive normal form:.