Asymmetric Hydrogenation of γ-Branched Allylamines for the Efficient Synthesis of γ-Chirogenic Amines

The efficient construction of γ-chirogenic amines has been realized via asymmetric hydrogenation of γ-branched N-phthaloyl allylamines by using a bisphosphine-Rh catalyst bearing a large bite angle. The desired products possessing different types of γ-substituents were obtained in quantitative yields and with excellent enantioselectivities (up to >99.9% ee). This protocol provided a practical method for the preparation of γ-chirogenic amine derivatives such as the famous antidepressant drug Fluoxetine (up to 50000 S/C). The mechanism calculation shows a weak interaction-promoted activation mode which is completely different from the traditional coordination-promoted activation mode in the Rh-catalyzed hydrogenation.

Self-driven dual hydrogen production system based on bifunctional single-atomic Rh catalyst

Electrocatalytic hydrogen evolution is an efficient and economical technology to address environmental contamination and energy crises, but the development of such a sustainable hydrogen production system with high-efficiency and energy-saving...

Role of Surface Hydroxyl Groups on Single-Atomic Rh1/ZrO2 Catalyst for Direct Methane Oxidation

Single atomic Rh catalyst immobilized on zirconia (Rh1/ZrO2) was modified by hydrothermal treatment to have surface hydroxyl groups and used for direct methane oxidation. Both O2 and H2O2 were used...