Molecular mechanisms of a traditional Chinese medicine in the treatment of dysfunctional uterine bleeding

Dysfunctional uterine bleeding (DUB) is a common gynecological disease regulated by multiple hormones, which seriously affects female physical and mental health. Some drugs have been prompted to cure this disease, but most drugs have certain side effects and limitations. In the present study, we demonstrated an unexploited Chinese traditional medicine, a combination of Saururus chinensis, Celosia cristata and Spatholobus suberectus (Referred to as XBR), was capable of exerting hemostatic, coagulation and anti-inflammatory effects on SD rats. Furthermore, the XBR decreased the value of erythrocyte, hemoglobin, and hematocrit in serum for lowering blood stasis caused by DUB. Further studies were conducted to provide direct evidence that the recovery of endometrial hyperplasia was associated with the modulation of the hormones (follicle-stimulating hormone, luteinizing hormone, estradiol and progesterone). Besides, XBR altered mRNA expression levels of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 on the uterine endometrium, thereby promoting the repair of proliferating endometrium in the rats. Collectively, our study indicates that XBR harbors a profoundly curative effect on the treatment of DUB, and explains the mechanism at the molecular and genes expression levels.

A COMPREHENSIVE REVIEW OF PHYTOCHEMICAL AND PHARMACOLOGICAL OVERVIEW ON CELOSIA CRISTATA FOR FUTURE PROSPECTIVE RESEARCH

Celosia cristata (CC) is used in traditional medicine to cure several disorders. It is a member of the genus Celosia and is commonly known as cockscomb, since the flower looks like the head on a rooster. Many sensitive ingredients were isolated from different parts of the plant. The recent studies showed that the plant exerted a wide range of pharmacological activities. The chemical constituents and pharmacological activities of CC were presented in this review.