Effect of Tooth Agenesis on Mandibular Morphology and Position

Congenital missing teeth (OMIM #106600) is the most common dental abnormality. The aim of the study was to evaluate the effects of tooth agenesis on the total mandibular length, length of the mandibular body and alveolar process, and the mandibular anteroposterior position. The material was obtained from the Department of Orthodontics, Medical University of Warsaw. The study group included 116 patients aged 9–18 years with a congenital absence of at least two permanent tooth buds in the maxilla and/or mandible (mean: 6.2 teeth missing/patient). All patients were Caucasians: 68 (59%) females and 48 (41%) males. The control group included 115 patients without tooth agenesis matched with the age and gender of the study group. A cephalometric analysis was performed, and it was focused on assessing anteroposterior mandibular measurements. This assessment was based on 17 measurements (12 linear and 5 angular). Statistical analysis of the cephalometric measurements between the study group and the control group showed significant changes regarding selected mandibular measurements. Tooth agenesis does not affect the total length of the mandible and the length of the mandibular body, but it might reduce the length of the mandibular arch length and result in a more retrusive mandibular position.

Case Report: Variations in the ALPL Gene in Chinese Patients With Hypophosphatasia

Background: Hypophosphatasia (HPP) is an autosomal genetic disorder characterized biochemically by abnormal of bone parameters and serum alkaline phosphatase (ALP) activity as well as clinically by deficiency of teeth and bone mineralization. The clinical presentation is a continuum ranging from a prenatal lethal form with no skeletal mineralization to a mild form with late adult onset presenting with non-pathognomonic symptoms. ALP deficiency is the key to the pathogenesis of abnormal metabolism and skeletal system damage in HPP patients.Methods: We investigated five patients with skeletal dysplasia in the clinic. Whole-exome sequencing was performed in order to aid diagnosis of the patients.Results: Eight variants in the ALPL gene in the five unrelated Chinese patients (PA-1: c.649_650insC and c.707A > G; PA2: c.98C > T and c.707A > G; PA3: c.407G > A and c.650delTinsCTAA; PA4: c.1247G > T (homozygous); PA5: c.406C > T and c.1178A > G; NM_000478.5) were found. These variations caused two types of HPP: perinatal HPP and Odonto HPP. All cases reported in this study were autosomal recessive. Among the variants, c.1247G > T/p.Gly416Val (PA-4); c.1178A > G/p.Asn393Ser (PA-5) and c.707A > G/p.Tyr236Cys (PA-1, PA-2) have never been reported before.Conclusion: Clinical phenotypes of perinatal HPP (PA-1,PA-2,PA-3 and PA-4) include skeletal dysplasia, shorter long bones, bowing of long bones, tetraphocomelia, abnormal posturing and abnormal bone ossification. Odonto HPP (PA-5) only presents as dental abnormality with severe dental caries and decreased ALP activity. Our study extends the pool of ALPL variants in different populations.

Palatal rugoscopy: Individuality and gender differences in subset of population of Karachi.

Objectives: To evaluate the individuality of palatal rugae patten and correlate them in males and females in different age groups by using Trobo’s classification. Study Design: Cross Sectional. Setting: Department of Prosthodontics, Dow Dental College, Dow University of Health Sciences. Period: September 2019 to January 2020. Material & Methods: This study comprised of ninety-four participants with equal number of males and females from 10 years to 70 years, visiting the Prosthodontic department. Study casts included were free of dental abnormality, trauma, malocclusion, orthodontic problems, and deformity in palatal rugae area. Sample size was calculated from software name openepi.com with 95% confidence interval. Data was tabulated and SPSS version 22.0 was used to identify the results. Results: Frequency distribution was performed among age groups in which second group (20 to 39 years) has highest frequency with 52 in number. The cross tab between age group and type of rugae was made which showed group II, having age between 20 to 39 years, had the highest number of palatal rugae configurations amongst all. Conclusion: Sinuous or type E was the predominant type of palatal rugae found in this study. The study did not show significant difference in gender, however number of rugae were found consistently more in young adults with propensity towards individuality. Their use can thus be justified for dental identification in forensic odontology.

Dental abnormalities in a patient with autosomal dominant hyper-IgE syndrome: A case control study

Autosomal-dominant hyper-IgE (AD-HIES) is mainly characterized by eczematous dermatitis, staphylococcal skin abscesses, connective tissue defects, and elevated serum IgE. This disorder is largely associated with heterozygous dominant-negative mutations in STAT3 gene. Herein, we reported a patient with AD-HIES suffering from dental abnormality and allergic reactions.

Child Perception Questionnaire for Oral Symptoms of Hypodontia Children

Background: The congenital absence of one or more deciduous or permanent teeth is called hypodontia. It is the most prevalentcongenital dental abnormality. Hypodontia could be caused by a number of genetic and environmental factors.Objectives: The aim of the current study was to find out the impact of hypodontia on oral health and quality of life of children.Material and Methods: A cross sectional comparative study was carried out on 40 patients suffering from hypodontia and 40healthy controls in the outpatient department of Nishtar institute of dentistry, Multan. Patients and healthy controls were selected bynon-probability convenient sampling technique without any gender discrimination. Age of the selected patients and controls was11-14 years. Oral health was checked by using dental examination instruments. Urdu Proformas were used for betterunderstanding of children.Results: Mean age of the study subjects was 11.9 (± 0.94) years with range of 11 to 14 years. There was 36 (45%) male and 44(55%) female. In our study, maxillary lateral incisor was the most commonly missing tooth. Out of 40 patients suffering fromhypodontia, about 37 (92.5%) patients presented with poor oral health, 38 (95%) patients were affected by their condition and31(77.5%) patients were dissatisfied from their appearance.Conclusion: Hypodontia had great impact on the quality of life of the children. Patients presented with poor oral health and werehighly dissatisfied from their condition.Keywords: Hypodontia, oral health, quality of life

Features of clinical manifestations in patients suffering from dental abnormality

Anomalies of the dentition represent one of the most common groups of pathologies in dentistry. Many complaints made by patients with dentofacial anomalies (CCA) make this problem quite relevant. In this regard, of particular interest is a more detailed study of the features of clinical manifestations in patients suffering from RF.Material and methods. The study involved 118 people with deep incisal overlap (hydraulic fracturing), the average age was 38.7 8.5 years; women accounted for 54.24%; men-45.76%. Determining the dental status for studying the clinical manifestations of abnormalities included: studying the anamnesis, patient complaints, internal and external oral examinations. When analyzing the results of the study, biostatistical methods were used.Results. An analysis of the data allows clustering of patients' complaints into the following groups: painful, functional and aesthetic. During a dental examination of patients with hydraulic fracturing, increased abrasion of the teeth, increased tone of the chewing muscles proper, and a change in the ratio of elements of the temporomandibular joint (TMJ) were visualized.Conclusions. The variety of patient complaints with this pathology indicates the relevance of this problem. Most complaints of an aesthetic nature both among women and among men are a manifestation of dissatisfaction with the appearance.

Clinical and Epidemiological Study of Supernumerary Teeth in Patients from Plovdiv Region

Abnormalities in the number of teeth are conditions that occur predominantly in childhood. Therefore, monitoring the prevalence and early diagnosis is very important for the timely and appropriate therapeutic approach. The aim of the study was to investigate the incidence of supernumerary teeth in patients from the city of Plovdiv.Methods and equipment: 1,000 dental patients were studied. Data were collected from patients seeking medical attention at the Faculty of Dental Medicine in Plovdiv. We used clinical, X-ray and statistical methods for investigation.Results: A 1.1% prevalence of supernumerary teeth (ST) was observed in the studied patients. A statistically significant difference was found between the presence of ST in the permanent and mixed dentition, with a 3% relative proportion of ST in the mixed and 0.62% in the permanent dentition (p < 0.05). The relative proportion of ST in the maxilla was 90.9%, and in the mandible – 9.1%. A statistically significant difference (p < 0.05) was found in the distribution of ST by jaws. In our study, a higher frequency of mesiodens and distomolar (1.08% and 0.22%, respectively) was found in males, and a decreasing relative proportion from the midline to distally in females (mesiodens – 0.56%, paramolar – 0.19%, distomolar – 0.19%).Conclusion: Supernumerary teeth are a relatively rare dental abnormality in the Bulgarian population. Its distribution by sex and morphology corresponds to the prevalence in Caucasians and populations of southern countries.

Assessing the Validity of Animal-Based Indicators of Sheep Health and Welfare: Do Observers Agree?

Sixteen animal-based indicators of sheep welfare, previously selected by a stakeholder panel, and based on the Farm Animal Welfare Council (FAWC) Five Freedoms, were assessed in terms of the level of inter-observer agreement achieved during on-farm testing. Eight observers independently tested the 16 indicators on 1158 sheep from 38 farms in England and Wales. Overall inter-observer agreement was evaluated by Fleiss’s kappa (κ), and the pair-wise agreement of each observer was compared to a ‘test standard’ observer (TSO). Inter-observer assessments of the welfare indicators; dental abnormality, cleanliness score (ventral abdomen), mastitis, tail length, skin lesions, body condition scoring and lameness produced ‘fair to good’ levels of agreement (0.40 < κ < 0.75) and joint swellings had ‘excellent’ levels of agreement (κ ≥ 0.75). The very low apparent prevalence (<0.8%) of sheep with specific outcomes such as pruritis, wool loss, myiasis, thin body condition, diffuse or severe skin lesions limited kappa analysis for these indicators. Overall, findings suggest that observers of differing experience, training and occupation were reliable in assessing key animal-based indicators of sheep health and welfare.

Concrescence: Cone-Beam Computed Tomography Imaging Perspective

Concrescence is a form of twinning, formed by the confluence of cementum of two teeth at the root level. The diagnosis of concrescence has largely relied on the conventional 2D imaging. The 2D imaging has inherent limitations such as distortion and superimposition. Cone-Beam CT eliminates these limitations. The aim of this article was to describe a case of dental abnormality using Cone-Beam CT imaging modality. Volumetric data demonstrated confluence of left mandibular third molar with a paramolar, a supernumerary tooth. To our knowledge, this is the second case in the dental literature reported demonstrating the use of Cone-Beam CT in the diagnosis of concrescence.

Double teeth: evaluation of 10-years of clinical material

The aim of the study was to evaluate 10-years of clinical material referring to the rare dental abnormality of double teeth. The study material consisted of case records, operation-books and radiographic or photographic documentation on patients treated in the Department of Oral Surgery, Silesian Medical University, Katowice, from the 1st of June 2000 to the 31st of May 2010. The following features were considered important: age and sex, the reason why the patient reported for treatment, general state of health, the time of recognition and type of double teeth, location of double teeth, complaints and disturbances connected with double teeth, types of radiographs, the radiographic and macroscopic appearance of double teeth and treatment method. Diagnoses were as follows: eight conrescent teeth, two fused teeth, two geminated teeth and one invaginated tooth. The anomaly of a deciduous tooth was referred to in one case only. Double teeth were most often seen in the region of maxillary incisors and molars but rarely in the mandible. The region of incisors was affected chiefly in children and the region of molars in adults. Double incisors are usually recognized prior to treatment whereas double molars as late as during their extraction. In many cases, neither intraoral radiographs nor pantomographs help to confirm double teeth or provide sufficient information to plan the treatment. In such a situation, CT or CBCT should be used in addition to imaging diagnostics. Double teeth among incisors are usually accompanied by occlusal disorders. Therefore the therapeutic management is conducted by a team, including orthodontists.