Efficient and stable radiolabeling of polycyclic aromatic hydrocarbon assemblies: in vivo imaging of diesel exhaust particulates in mice

As a robust radioanalytical method for tracking carbonaceous particulates in vivo, polycyclic aromatic hydrocarbons from diesel exhaust were labeled with a radioactive-iodine-tagged pyrene analogue.

Study of radiotoxic 210Po in Indian tobacco using liquid scintillation spectrometry

A fast radioanalytical method has been developed to measure 210Po in tobacco samples. After microwave digestion polonium is extracted quantitatively from a 1 M hydrochloric acid solution into a solution of triisooctylamine in toluene. The extract was measured by liquid scintillation counting in α mode. Caused by the high counting efficiency the counting time per sample can be reduced significantly compared to conventional α spectrometry, allowing for high sample throughput. The method was applied to 11 brands of cigarettes, beedis and or chewing tobaccos from India. Based on the resulting activity concentrations and typical consumption habits, annual and lifetime equivalent doses were calculated. They were found to be ~100–700 μSv/a or ~5–35 mSv, respectively.

Public Health Laboratories and Radiological Readiness

ABSTRACTObjective: To document the ability of public health laboratories to respond to radiological emergencies.Methods: The Association of Public Health Laboratories developed, distributed, and analyzed two separate surveys of public health laboratories representing the 50 US states and major nonstate jurisdictions. The 2009 All-Hazards Laboratory Preparedness Survey examined overall laboratory capability and capacity, with a subset of questions on radiation preparedness. A 2011 survey focused exclusively on radiation readiness.Results: The 50 state and District of Columbia public health laboratories responded to the 2009 All-Hazards Laboratory Preparedness Survey, representing a 98% response rate. In addition to the above laboratories, environmental and agricultural laboratories responded to the 2011 Radiation Capabilities Survey, representing a 76% response rate. Twenty-seven percent of the All-Hazards Survey respondents reported the ability to measure radionuclides in clinical specimens; 6% reported that another state agency or department accepted and analyzed these samples via a radioanalytical method. Of the Radiation Capabilities Survey respondents, 60% reported the ability to test environmental samples, such as air, soil, or surface water, for radiation; 48% reported the ability to test nonmilk food samples; 47% reported the ability to test milk; and 56% reported sending data for drinking water to the Environmental Protection Agency.Conclusions: Survey data reveal serious gaps in US radiological preparedness. In 2007, federal experts estimated it would take more than 4 years to screen 100 000 individuals for radiation exposure and 6 years to test environmental samples from a large-scale radiological emergency, relying on existing laboratory assets. Although some progress has been made since 2007, public health laboratory radiological test capabilities and capacities remain insufficient to respond to a major event. Adequate preparation requires significant new investment to build and enhance laboratory emergency response networks, as well as investments in the broader public health system in which public health laboratories function.(Disaster Med Public Health Preparedness. 2011;5:213-217)