Hydrogen Bonding Directed Self-Assembly of a Binuclear Ag(I) Metallacycle into a 1D Supramolecular Polymer

An Ag(I) metallacycle obtained unexpectedly during the preparation of Pd(II) complexes of the bifunctional ligand 5-([2,2’-bipyridin]-5-yl)pyrimidine-2-amine (L) has been characterized using X-ray structure determination as a binuclear, metallacyclic species [Ag2L2](SbF6)2, where both the bipyridine and pyrimidine-N donors of L are involved in coordination to the metal. The full coordination environment of the Ag(I) defines a case of highly irregular 4-coordination. In the crystal, the Ag-metallacycles assemble into one-dimensional supramolecular metalladynamers linked together by hydrogen-bonding interactions.

Bifunctional Ligand-Assisted Cu-Catalyzed Intermolecular Cyclo-hexenone γ‑C(sp3)-H Amination: Controlled Synthesis of p-Aminophenols

A 1,10-phenanthroline-type bifunctional ligand has been developed for Cu catalyzed direct γ-C(sp3)-H amination with intermolecular anilines. Stabilizing N-centered radicals via amide group installed on the bifunctional ligands, a new catalytic system for site-selective γ-C(sp3)-H amination to synthesize p-aminophenols was established. The economical and practical approach by using oxygen as the terminal oxidant was mild and environmental friendly.

Detection of four quinolone antibiotic by chemiluminescence based on a novel Nor-Biotin bifunctional ligand and SA-ALP technology

A simple and effective direct competitive chemiluminescence immunoassay for detection of four kind of quinolone antibiotics in milk was established using Nor-Biotin(biotin-modified Norfloxacin) bifunctional ligand and SA-ALP signal amplification technology. The polyclonal antibody was obtained after immunization of New Zealand White rabbits using Norfloxacin-derived antigen. ”Click chemistry” was used for the rapid and facile synthesis of the Nor-Biotin bifunctional ligand. After the optimization of the incubation time and reaction buffer, the direct competitive ChemiLuminescence assay (dcCLIA) method was developed and used for sensitive detection of four kinds of quinolone drugs (norfloxacin (NOR), pefloxacin (PFLX), ciprofloxacin (CIP), and danofloxacin (DFLX)). The IC50 of the four kinds of quinolone drugs ranged from 7.35 ng/mL to 24.27 ng/mL, and the lowest detection limits (LOD) ranged from 0.05 ng/mL to 0.16 ng/mL, which were below their maximum residue levels (MRLs), approved by the EU for treatment of food-producing animals. To demonstrate the applicability of the assay, artificially contaminated milk samples with the four-quinolone drugs were analyzed. The mean recovery rates of the drugs ranged from 86.31% to 112.11%.

Luminescence sensing and photocatalytic activities of four Zn(ii)/Co(ii) coordination polymers based on a pyridinephenyl bifunctional ligand

Four Zn(ii)/Co(ii) CPs act as bifunctional materials in the detection of Fe(iii) cation, Cr(vi) anion, and nitrofuran antibiotics and removal of methylene blue in aqueous media.