acetogenic bacterium
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Author(s):  
Jimyung Moon ◽  
Judith Dönig ◽  
Sina Kramer ◽  
Anja Poehlein ◽  
Rolf Daniel ◽  
...  

Author(s):  
Dragan TrifunoviĆ ◽  
Jimyung Moon ◽  
Anja Poehlein ◽  
Rolf Daniel ◽  
Volker Müller

2021 ◽  
Vol 321 ◽  
pp. 124521
Author(s):  
Ji-Yeon Kim ◽  
Sehoon Park ◽  
Jiyeong Jeong ◽  
Mungyu Lee ◽  
Byeongchan Kang ◽  
...  

2021 ◽  
Vol 9 (2) ◽  
pp. 258
Author(s):  
Anja Wiechmann ◽  
Volker Müller

In times of global warming caused by the extensive use of fossil fuels, the need to capture gaseous carbon compounds is growing bigger. Several groups of microorganisms can fix the greenhouse gas CO2. Out of these, acetogenic bacteria are role models in their ability to reduce CO2 with hydrogen to acetate, which makes acetogens prime candidates for genetic modification towards biotechnological production of value-added compounds from CO2, such as biofuels. However, growth of acetogens on gaseous substrates is strongly energy-limited, and successful metabolic engineering requires a detailed knowledge of the bioenergetics. In 1939, Clostridium aceticum was the first acetogen to be described. A recent genomic study revealed that this organism contains cytochromes and therefore may use a proton gradient in its respiratory chain. We have followed up these studies and will present data that C. aceticum does not use a H+ but a Na+ gradient for ATP synthesis, established by a Na+-Rnf. Experimental data and in silico analyses enabled us to propose the biochemistry and bioenergetics of acetogenesis from H2 + CO2 in C. aceticum.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Luise Göbbels ◽  
Anja Poehlein ◽  
Albert Dumnitch ◽  
Richard Egelkamp ◽  
Cathrin Kröger ◽  
...  

AbstractBiohybrids composed of microorganisms and nanoparticles have emerged as potential systems for bioenergy and high-value compound production from CO2 and light energy, yet the cellular and metabolic processes within the biological component of this system are still elusive. Here we dissect the biohybrid composed of the anaerobic acetogenic bacterium Moorella thermoacetica and cadmium sulphide nanoparticles (CdS) in terms of physiology, metabolism, enzymatics and transcriptomic profiling. Our analyses show that while the organism does not grow on l-cysteine, it is metabolized to acetate in the biohybrid system and this metabolism is independent of CdS or light. CdS cells have higher metabolic activity, despite an inhibitory effect of Cd2+ on key enzymes, because of an intracellular storage compound linked to arginine metabolism. We identify different routes how cysteine and its oxidized form can be innately metabolized by the model acetogen and what intracellular mechanisms are triggered by cysteine, cadmium or blue light.


2020 ◽  
Vol 1861 (11) ◽  
pp. 148263 ◽  
Author(s):  
Martin Kuhns ◽  
Verena Schuchmann ◽  
Silke Schmidt ◽  
Thorsten Friedrich ◽  
Anja Wiechmann ◽  
...  

2020 ◽  
Vol 11 ◽  
Author(s):  
Nilanjan Pal Chowdhury ◽  
Lydia Alberti ◽  
Mark Linder ◽  
Volker Müller

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