RISK FACTOR FOR UNSUCCESSFUL RATE OF PRETERM LABOR INHIBITION WITH TOCOLYTIC AGENT IN PREGNANT WOMEN 240/7-336/7 WEEKS OF GESTATION AT MAHARAT NAKHON RATCHASIMA HOSPITAL

The objective is aimed to Assessing risk factors for unsuccessful rate of uterus contraction inhibition in pregnant women 240/7-336/7 weeks of gestation in Maharat Nakhon Ratchasima Hospital The retrospective cohort study approved by the Research Ethics committee of, Maharat Hospital, Nokhon Ratchasima Province Thailand studying pregnant women who were diagnosed with preterm labor pain with gestrational age of 240/7-336/7 weeks at the delivery ward of Maharat Nakhon Ratchasima Hospital and received Dexamethasone(corticosteroid) for the first time in every case between 1 January 2016 – 31 December 2018. From 361 pregnant women with preterm labor pain, 169 women were successful inhibition which was 54.29%. The group with failure inhibition were 165 women which was 45.71%. The factors relating to unsuccessful inhibition of uterus contraction were ANC less than 5 times, Adjusted odd ratios(AORs) 1.74; 95%CI 1.01-3.03, multiple pregnancy AORs 4.42 ; 95%CI 1.96-9.97 Cervical dilatation ≥3 cm AORs 5.93; 95%CI 3.44-10.22, the Effacement ≥ 80%, AORs 3.39; 95%CI 2.07-5.55, transfer from another hospital AORs 13.96; 95%CI 5.24-37.19. The research concludes that the factors relating to unsuccessful inhibition of uterus contraction were ANC less than 5 times, multiple pregnancy, Cervical dilatation ≥3 centimeters, Effacement ≥ 80%,and pregnant women referred from Secondary care center

Review: Practical Use of n-3 Fatty Acids to Improve Reproduction Parameters in the Context of Modern Sow Nutrition

The effects of long-chain polyunsaturated fatty acids (LC PUFAs) have been frequently investigated in sows because the profitability of pig production depends mainly on reproduction performance. In feeding trials, different sources and doses of n-3 PUFAs-rich feeds were used with various breeds and stages of production; however, a discrepancy in the response of n-3 PUFAs on sow reproduction has been observed. According to the results of the previous studies, n-3 fatty acids can postpone the time of parturition, decreasing the synthesis of prostaglandins, which are necessary for uterus contraction during labour. These effects could also be useful during the post-weaning period when low prostaglandin levels are indispensable for embryo survival. The n-3 fatty acids fed during the lactation period secreted in milk, may improve piglet performance. In this review, we will focus on the contradictory results of previous studies concerning practical swine nutrition. The main purpose of the review is to highlight those periods of swine breeding when the use of n-3 fatty acids may be advantageous in case of the deficiency of these essential nutrients. In finding the appropriate dose of n-3 PUFAs in terms of sow nutrition, the n-6 PUFAs levels in the given feeds must be taken into account to ensure that there are no significant reductions in the final n-6/n-3 ratio. Despite the numerous previous field trials, there are no current feeding recommendations available for PUFAs in swine nutrition. Hence, more research is required in different practical feeding situations to certify the assumptions and conclusions of this review.

Effect of Matricaria chamomilla hydro-alcoholic and flavonoids rich extracts on rat isolated uterus

Introduction: Pharmacological studies confirm antispasmodic activities of chamomile (Matricaria chamomilla) extract on intestinal smooth muscles and it has been suggested that chamomile increases uterus tone, but so far there is no scientific studies which support this assumption. Therefore, this study was designed to determine spasmodic and spasmolytic activities of M. chamomilla extracts on rat isolated uterus. Methods: Hydro-alcoholic extract of M. chamomilla was prepared by maceration technique. Flavonoids rich extract was prepared by liquid in liquid extraction technique. The spasmodic effects of the extracts were assessed on spontaneously contracting rat uterus. The myorelaxant effect of M. chamomilla extracts was validated on isolated uterus contractions induced by KCl, acetylcholine (ACh), electrical field stimulation (EFS) and oxytocin. Results: Hydro-alcoholic extract of M. chamomilla (0.8 and 1.6 mg/mL) enhanced spontaneous movement of rat isolated uterus smooth muscle suspended in an organ bath. On the other hand, flavonoids rich fraction only diminished uterus contractile activities. Flavonoids rich extract of the plant at bath concentration ranges of 40 μg/mL to 400 μg/mL attenuated uterus response to ACh, KCl, EFS and oxytocin. The hydro-alcoholic extract of M. chamomilla at higher concentration ranges (250 μg/mL to 1.5 mg/mL) inhibited uterus contractions induced by the above spasmogens. Conclusion: The present study confirms both spasmodic and spasmolytic activities M. chamomilla hydro-alcoholic extract. Therefore, medicinal use of the crude extract of M. chamomilla may initiate uterus contraction which could increase risk of spontaneous miscarriage or premature parturition.

Regulation of Actin Dynamics in the C. elegans Somatic Gonad

The reproductive system of the hermaphroditic nematode C. elegans consists of a series of contractile cell types—including the gonadal sheath cells, the spermathecal cells and the spermatheca–uterine valve—that contract in a coordinated manner to regulate oocyte entry and exit of the fertilized embryo into the uterus. Contraction is driven by acto-myosin contraction and relies on the development and maintenance of specialized acto-myosin networks in each cell type. Study of this system has revealed insights into the regulation of acto-myosin network assembly and contractility in vivo.

Correlation of Calcium Levels With The Strenght of Uterus Contraction on The Active Phase of First Stage Labor

Contributing factor to uterus contraction mechanism is the imbalance of the extracellular calcium level. When extracellular calcium level is inadequate, response of the myometrium to oxytocin decreased and the calcium influx inter-cell membranes are suppressed, thus inhibit uterine contractions. The aim of this research is to know the correlation between levels of calcium and the strength of uterine contraction in the active phase of first stage labor. This was a cross-sectional analytic correlative study in the Dr. Rasidin Hospital Padang and UPTD Health Laboratory in West Sumatra province, in was conducted from November 1st, 2014 till February 2016. Sampling was takes by using non probability sampling with consecutive sampling. Subjects of this research were the active phase of first stage labor of 62 people. Kolmogorof Smirnov normality test was used to the normality of the data. Pearson correlation test was conducted to examine the correlation between dependent and independent variables. Mean levels of calcium in the the stage I of labor respondents active phase (8.94 ±0,71), while mean strength of uterine contractions in active phase of first stage labor(56.77±11,84), there was positive correlation (r = 0,62) between the levels of calcium in the strength of uterine contractions (p < 0.05). The conclusion of the study there was a significant correlation between the levels of calcium in the strength of uterine contractions.