pithed rabbit
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1987 ◽  
Vol 91 (3) ◽  
pp. 457-466 ◽  
Author(s):  
J.M. Bulloch ◽  
J.R. Docherty ◽  
N.A. Flavahan ◽  
J.C. McGrath ◽  
C.E. McKean

1985 ◽  
Vol 7 (2) ◽  
pp. 251-257 ◽  
Author(s):  
H. Majewski ◽  
L. Hedler ◽  
C. Schurr ◽  
K. Starke

1985 ◽  
Vol 68 (s10) ◽  
pp. 25s-30s ◽  
Author(s):  
T. L. Grant ◽  
N. A. Flavahan ◽  
J. Greig ◽  
J. C. McGrath ◽  
C. E. McKean ◽  
...  

1. By the sequential administration of α1- and α2-blockers it can be shown, in the pithed rabbit, that the dose/pressor response curve to noradrenaline consists of two separate curves, one for each receptor. α2-mediated responses predominate at low doses and α1-mediated responses predominate at high doses. Pressor responses to sympathetic nerve stimulation have, similarly, an α2 component at low frequencies and a dominant α1-mediated response at high frequencies: a residual response is resistant to combined α1- plus α2-blockade. 2. This α-blocker-resistant pressor nerve response was further analysed in the pithed rat and was found to be partly susceptible to α,β-methylene ATP, which densitizes purinergic responses. However, reserpine pretreatment produced a greater reduction of nerve-mediated pressor responses than did α-blockade, suggesting that part of the ‘α-blocker resistant’ response might be adrenergic. 3. It is concluded that sympathetic vasopressor nerve transmission is mediated for the greater part by α1- and α2-adrenoceptors but that there is evidence for contributions from non-α-adrenergic and ‘purinergic’ elements. An even greater proportion of the responses to circulating catecholamines is attributable to the α-receptors with a relatively small but significant ‘resistant’ component.


1984 ◽  
Vol 6 (5) ◽  
pp. 888-896 ◽  
Author(s):  
H. Majewski ◽  
L. Hedler ◽  
C. Schurr ◽  
K. Starke

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