interdigitating cell
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2018 ◽  
Vol 93 (2) ◽  
pp. 519-524 ◽  
Author(s):  
Eishin Yaoita ◽  
Yutaka Yoshida ◽  
Masaaki Nameta ◽  
Hiroki Takimoto ◽  
Hidehiko Fujinaka

2014 ◽  
Vol 127 (6) ◽  
pp. 937-939 ◽  
Author(s):  
Caterina Giannini ◽  
Jonathan D. Fratkin ◽  
Josephine Wyatt-Ashmead ◽  
Patrice C. Abell Aleff

2012 ◽  
Vol 15 (1_suppl) ◽  
pp. 181-210 ◽  
Author(s):  
Jennifer Black ◽  
Cheryl M. Coffin ◽  
Louis P. Dehner

Fibrohistiocytic tumors (FHTs) in children and adolescents range from the benign fibrous histiocytoma, or dermatofibroma, to a variety of intermediate and malignant neoplasms, such as dermatofibrosarcoma protruberans and high-grade undifferentiated pleomorphic sarcoma (malignant fibrous histiocytoma). Those tumors as a group are comprised of fibroblasts, myofibroblasts, and histiocytes-dendritic cells with a variably prominent inflammatory infiltrate consisting of lymphocytes and eosinophils. Dendritic cells are also a major constituent of another group of neoplasms that include Langerhans cell histiocytosis, follicular and interdigitating cell sarcomas, and juvenile xanthogranuloma. These latter tumors are considered in this discussion for the sake of differential diagnosis and their possible histogenetic relationship to FHTs. Recent studies have suggested that the relationship between the fibroblast and histiocyte in the FHTs may reflect the intrinsic capacity to transdifferentiate from one to the other morphologic and functional state. The so-called “facultative fibroblast,” as a cell with fibroblastic and histiocytic properties, was discussed in the context of the fibrous xanthoma 50 years ago. Possibly the entire histogenetic concept of FHTs should be reconsidered in light of current studies.


2008 ◽  
Vol 44 (5) ◽  
pp. 374-386 ◽  
Author(s):  
Shigeo Nakamura ◽  
Takashi Koshikawa ◽  
Kuniyoshi Kitoh ◽  
Atsuo Nakayama ◽  
Mitsunori Yarnakawa ◽  
...  

Blood ◽  
2008 ◽  
Vol 111 (12) ◽  
pp. 5433-5439 ◽  
Author(s):  
Andrew L. Feldman ◽  
Daniel A. Arber ◽  
Stefania Pittaluga ◽  
Antonio Martinez ◽  
Jerome S. Burke ◽  
...  

Abstract Rare cases of histiocytic and dendritic cell (H/DC) neoplasms have been reported in patients with follicular lymphoma (FL), but the biologic relationship between the 2 neoplasms is unknown. We studied 8 patients with both FL and H/DC neoplasms using immunohistochemistry, fluorescence in situ hybridization (FISH) for t(14;18), and polymerase chain reaction (PCR)/sequencing of BCL2 and IGH rearrangements. There were 5 men and 3 women (median age, 59 years). All cases of FL were positive for t(14;18). The H/DC tumors included 7 histiocytic sarcomas, 5 of which showed evidence of dendritic differentiation, and 1 interdigitating cell sarcoma. Five H/DC tumors were metachronous, following FL by 2 months to 12 years; tumors were synchronous in 3. All 8 H/DC tumors showed presence of the t(14;18) either by FISH, or in 2 cases by PCR with the major breakpoint region (MBR) probe. PCR and sequencing identified identical IGH gene rearrangements or BCL2 gene breakpoints in all patients tested. All H/DC tumors lacked PAX5, and up-regulation of CEBPβ and PU.1 was seen in all cases tested. These results provide evidence for a common clonal origin of FL and H/DC neoplasms when occurring in the same patient, and suggest that lineage plasticity may occur in mature lymphoid neoplasms.


Cell ◽  
2005 ◽  
Vol 120 (5) ◽  
pp. 687-700 ◽  
Author(s):  
Ying Fu ◽  
Ying Gu ◽  
Zhiliang Zheng ◽  
Geoffrey Wasteneys ◽  
Zhenbiao Yang

2005 ◽  
Vol 45 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Kunihiko Maeda ◽  
Tomoko Takahashi ◽  
Chihiro Saitoh ◽  
Keiko Watarai ◽  
Kiriko Wada ◽  
...  

1992 ◽  
Vol 97 (1) ◽  
pp. 139-146 ◽  
Author(s):  
Mitsunori Yamakawa ◽  
Mikio Matsuda ◽  
Yutaka Imai ◽  
Shigeru Arai ◽  
Kohji Harada ◽  
...  

1991 ◽  
Vol 7 (5) ◽  
pp. 553-555 ◽  
Author(s):  
Shigeo Nakamura ◽  
Sadayuki Kaba ◽  
Takashi Koshikawa ◽  
Taizan Suchi ◽  
Soji Kurita

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