aortic strip
Recently Published Documents


TOTAL DOCUMENTS

57
(FIVE YEARS 0)

H-INDEX

12
(FIVE YEARS 0)

2013 ◽  
Vol 62 (6) ◽  
pp. 530-538 ◽  
Author(s):  
Takeharu Niioka ◽  
Hisayuki Ohata ◽  
Kazutaka Momose ◽  
Kazuo Honda

2013 ◽  
Vol 2013 ◽  
pp. 1-10
Author(s):  
Mossad Gamaleddin Ahmed Elsayed ◽  
Ashraf Abdelhakim Ahmed Elkomy ◽  
Mohamed Elbadawy

Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained. Cefepime maximally stimulated isolated guinea pig's ileum, rat's colon (80 μg/mL bath), and rabbit's duodenum (400 μg/mL bath). Contrarily, complete relaxation of isolated rat's fundic strip was produced by 80 μg/mL bath. Effects of cefepime on isolated rat's uterine muscle were different according to stage of sex cycle. Cefepime did not induce any effects on the resting tonus of isolated guinea pig's tracheal chain and rabbit's aortic strip. Concentrations of 200 and 400 μg/mL bath induced marked inhibition in the force of muscular twitches of the isolated frog's gastrocnemius muscle which was less potent than that induced by procaine hydrochloride 2%. Cefepime completely blocked the neuromuscular transmission of frog's rectus abdominis muscle (40 μg/mL bath) and rat's phrenic nerve hemidiaphragm preparation (200 μg/mL bath). This blockade was reversed by acetylcholine and neostigmine. Cefepime produced dose-dependent negative inotropic effect on isolated rabbit's heart and guinea pig's auricles. There were no changes in blood pressure and rate of respiration in anaesthetized dog after cefepime injection. These findings indicate that cefepime has a low potential to produce adverse reactions at therapeutic doses.


Pharmacologia ◽  
2013 ◽  
Vol 4 (5) ◽  
pp. 371-382
Author(s):  
Eric Woode ◽  
Felix Amissah ◽  
George Agyapong ◽  
George Kwaw Ainooson

Health ◽  
2013 ◽  
Vol 05 (06) ◽  
pp. 1016-1020
Author(s):  
Hozeifa Mohamed Hassan ◽  
Imad Mohamed Taj Eldin ◽  
Elhadi Mohamed Ahmed ◽  
Abd Elwahab Hassan Mohamed ◽  
Nizar Sirag

Life Sciences ◽  
2005 ◽  
Vol 77 (13) ◽  
pp. 1416-1424 ◽  
Author(s):  
Chin-Chuan Tsai ◽  
Tung-Yuan Lai ◽  
Wei-Chan Huang ◽  
I-Min Liu ◽  
Shorong-Shii Liou
Keyword(s):  

Sign in / Sign up

Export Citation Format

Share Document