Modulation of tactile feedback for the execution of dexterous movement

While dexterity relies on the constant transmission of sensory information, unchecked feedback can be disruptive to behavior. Yet how somatosensory feedback from the hands is regulated as it first enters the brain, and whether this modulation exerts any influence on movement, remain unclear. Leveraging molecular-genetic access in mice, we find that tactile afferents from the hand recruit neurons in the brainstem cuneate nucleus whose activity is modulated by distinct classes of local inhibitory neurons. Selective manipulation of these inhibitory circuits can suppress or enhance the transmission of tactile information, affecting behaviors that rely on movement of the hands. Investigating whether these local circuits are subject to top-down control, we identify distinct descending cortical pathways that innervate cuneate in a complementary pattern. Somatosensory cortical neurons target the core tactile region of cuneate, while a large rostral cortical population drives feed-forward inhibition of tactile transmission through an inhibitory shell. These findings identify a circuit basis for tactile feedback modulation, enabling the effective execution of dexterous movement.

CONAN: Complementary Pattern Augmentation for Rare Disease Detection

Rare diseases affect hundreds of millions of people worldwide but are hard to detect since they have extremely low prevalence rates (varying from 1/1,000 to 1/200,000 patients) and are massively underdiagnosed. How do we reliably detect rare diseases with such low prevalence rates? How to further leverage patients with possibly uncertain diagnosis to improve detection? In this paper, we propose a Complementary pattern Augmentation (CONAN) framework for rare disease detection. CONAN combines ideas from both adversarial training and max-margin classification. It first learns self-attentive and hierarchical embedding for patient pattern characterization. Then, we develop a complementary generative adversarial networks (GAN) model to generate candidate positive and negative samples from the uncertain patients by encouraging a max-margin between classes. In addition, CONAN has a disease detector that serves as the discriminator during the adversarial training for identifying rare diseases. We evaluated CONAN on two disease detection tasks. For low prevalence inflammatory bowel disease (IBD) detection, CONAN achieved .96 precision recall area under the curve (PR-AUC) and 50.1% relative improvement over the best baseline. For rare disease idiopathic pulmonary fibrosis (IPF) detection, CONAN achieves .22 PR-AUC with 41.3% relative improvement over the best baseline.

Hedgehog signaling patterns the oral-aboral axis of the mandibular arch

Development of vertebrate jaws involves patterning neural crest-derived mesenchyme cells into distinct subpopulations along the proximal-distal and oral-aboral axes. Although the molecular mechanisms patterning the proximal-distal axis have been well studied, little is known regarding the mechanisms patterning the oral-aboral axis. Using unbiased single-cell RNA-seq analysis followed by in situ analysis of gene expression profiles, we show that Shh and Bmp4 signaling pathways are activated in a complementary pattern along the oral-aboral axis in mouse embryonic mandibular arch. Tissue-specific inactivation of hedgehog signaling in neural crest-derived mandibular mesenchyme led to expansion of BMP signaling activity to throughout the oral-aboral axis of the distal mandibular arch and subsequently duplication of dentary bone in the oral side of the mandible at the expense of tongue formation. Further studies indicate that hedgehog signaling acts through the Foxf1/2 transcription factors to specify the oral fate and pattern the oral-aboral axis of the mandibular mesenchyme.

The Pattern of Cooperation between the Ministry of Environment and Forestry of the Republic of Indonesia and the Wildlife Conservation Society-Indonesia Programme in Dealing with the Illegal Transnational Trade of Pangolins in Indonesia

Indonesia is home to one of the world’s pangolins species whose status is protected internationally in the Appendix 1 Category of CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora). This means that pangolins are categorized vulnerable to extinction and are prohibited to be freely traded. However, since 1990, the number of pangolin populations in Indonesia has declined because of the threat of environmental degradation, illegal hunting and illegal trade. In responding the threat of pangolin extinction in Indonesia, the Indonesian government formed a collaborative initiative with International Non-Government Organizations working on wildlife conservation. This study aims to analyze the pattern of cooperation between the Ministry of Environment and Forestry (KLHK) with the Wildlife Conservation Society-Indonesia Programme (WCS-IP) in dealing with the illegal transnational trade of pangolins. This study used an analysis of interaction patterns of supplementary, complementary, and adversary in a state-non-state actor cooperation approach. The findings in this study showed that cooperation established based on supplementary patterns is carried out by providing capacity building assistance of law enforcement officers from WCS-IP to KLHK. The complementary pattern was by giving mandate to carry out the program from KLHK to WCS-IP, and the adversary pattern was by providing support as well as input by WCS-IP on government regulations and policies. Based on the analysis of the all of the patterns, the cooperation established is more dominated by using supplementary and complementary patterns because of the compatibility of the vision and mission, the intensity of coordination and trust of both parties.

Income inequality not gender inequality positively covaries with female sexualization on social media

Publicly displayed, sexualized depictions of women have proliferated, enabled by new communication technologies, including the internet and mobile devices. These depictions are often claimed to be outcomes of a culture of gender inequality and female oppression, but, paradoxically, recent rises in sexualization are most notable in societies that have made strong progress toward gender parity. Few empirical tests of the relation between gender inequality and sexualization exist, and there are even fewer tests of alternative hypotheses. We examined aggregate patterns in 68,562 sexualized self-portrait photographs (“sexy selfies”) shared publicly on Twitter and Instagram and their association with city-, county-, and cross-national indicators of gender inequality. We then investigated the association between sexy-selfie prevalence and income inequality, positing that sexualization—a marker of high female competition—is greater in environments in which incomes are unequal and people are preoccupied with relative social standing. Among 5,567 US cities and 1,622 US counties, areas with relatively more sexy selfies were more economically unequal but not more gender oppressive. A complementary pattern emerged cross-nationally (113 nations): Income inequality positively covaried with sexy-selfie prevalence, particularly within more developed nations. To externally validate our findings, we investigated and confirmed that economically unequal (but not gender-oppressive) areas in the United States also had greater aggregate sales in goods and services related to female physical appearance enhancement (beauty salons and women’s clothing). Here, we provide an empirical understanding of what female sexualization reflects in societies and why it proliferates.

On Creating Complementary Pattern Databases

A pattern database (PDB) for a planning task is a heuristic function in the form of a lookup table that contains optimal solution costs of a simplified version of the task. In this paper we introduce a method that sequentially creates multiple PDBs which are later combined into a single heuristic function. At a given iteration, our method uses estimates of the A* running time to create a PDB that complements the strengths of the PDBs created in previous iterations. We evaluate our algorithm using explicit and symbolic PDBs. Our results show that the heuristics produced by our approach are able to outperform existing schemes, and that our method is able to create PDBs that complement the strengths of other existing heuristics such as a symbolic perimeter heuristic.

Eye and head movements are complementary in visual selection

In the natural environment, visual selection is accomplished by a system of nested effectors, moving the head and body within space and the eyes within the visual field. However, it is not yet known if the principles of selection for these different effectors are the same or different. We used a novel gaze-contingent display in which an asymmetric window of visibility (a horizontal or vertical slot) was yoked to either head or eye position. Participants showed highly systematic changes in behaviour, revealing clear differences in the principles underlying selection by eye and head. Eye movements were more likely to move in the direction of visible information—horizontally when viewing with a horizontal slot, and vertically with a vertical slot. Head movements showed the opposite and complementary pattern, moving to reveal new information (e.g. vertically with a horizontal slot and vice versa). These results are consistent with a nested system in which the head favours exploration of unknown regions, while the eye exploits what can be seen with finer-scale saccades.

Liturgy or private devotion? Reappraising Warsaw, Biblioteka Narodowa, I. 3311

Scholars have typically characterized Warsaw, Biblioteka Narodowa, I. 3311, an unlocalized Anglo-Saxon gospel lectionary of the late tenth or early eleventh century, as a book intended for use in private devotional reading. Despite this, a study of the contents of the book indicates that it was used liturgically, possibly by an individual priest or a small clerical community. This article offers a reappraisal of the manuscript and its use based on the complementary pattern of gospel readings that is evident in the two sections of the book and the presence of previously unnoticed musical notation. It is argued that the volume was in fact used in the celebration of mass and should be added to the corpus of Anglo-Saxon liturgical books.

PAPC couples the Segmentation Clock to somite morphogenesis by regulating N-cadherin dependent adhesion

Vertebrate segmentation is characterized by the periodic formation of epithelial somites from the mesenchymal presomitic mesoderm (PSM). How the rhythmic signaling pulse delivered by the Segmentation Clock is translated into the periodic morphogenesis of somites remains poorly understood. Here, we focused on the role of Paraxial protocadherin (PAPC/Pcdh8) in this process. We show that in chicken and mouse embryos, PAPC expression is tightly regulated by the Clock and Wavefront system in the posterior PSM. We observed that PAPC exhibits a striking complementary pattern to N-Cadherin (CDH2), marking the interface of the future somite boundary in the anterior PSM. Gain and loss of function of PAPC in chicken embryos disrupt somite segmentation by altering the CDH2-dependent epithelialization of PSM cells. Our data suggest that clathrin-mediated endocytosis is increased in PAPC expressing cells, subsequently affecting CDH2 internalization in the anterior compartment of the future somite. This in turn generates a differential adhesion interface, allowing formation of the acellular fissure that defines the somite boundary. Thus periodic expression of PAPC downstream of the Segmentation Clock triggers rhythmic endocytosis of CDH2, allowing for segmental de-adhesion and individualization of somites.

Waders (Aves, Charadriiformes) in a Mediterranean remnant wetland: a year-round pilot study evidences contrasting patterns in diversity metrics

Around a yearly cycle (August 2011 - July 2012), we studied the assemblages of waders (Aves Charadriiformes) occurring in a Mediterranean remnant wetland, obtaining a set of diversity metrics. Mean total abundance shows a complementary pattern when compared to species richness and diversity: the highest values of mean total abundance were observed in December-January, due to high dominance of only one very abundant and gregarious species (the lapwing Vanellus vanellus). On the contrary, in this period, species richness and diversity showed the lowest values. These last metrics were highest in values during the April-September period when a large number of species of conservation concern utilize muddy areas as trophic and stop-over sites, due to the seasonal water stress. The highest values in species turnover index were observed between December-January and February-March when passage migrants (high richness, low abundance) substitute the wintering species (low richness, high abundance). Our data highlight that, in Mediterranean remnant wetlands, strategies should be addressed to increase the muddy suitable areas in the April-September period in order to maximize species richness and diversity. In fact, in these months these habitats host pre- and post-breeding migrant waders of conservation concern.