Evaluation and image quality comparison of ultra-thin fibre endoscopes for vascular endoscopy

Medical applications like vascular endoscopy can provide additional diagnostic value for future procedures [1]. For these applications an optimal compromise between image quality and fibre flexibility has to be identified. Image quality of endoscopes is normally estimated using flat test objects or charts. For the application of vascular endoscopy a tubular test set up seems to be more beneficial. We compare three fibre endoscopes with different diameters and number of integrated fibre according to image quality and flexibility. Based on the results a recommendation for possible applications in vascular endoscopy is given.

Photoacoustic viscoelasticity imaging dedicated to mechanical characterization of biological tissues

Since changes in mechanical properties of biological tissues are often closely related to pathology, the viscoelastic properties are important physical parameters for medical diagnosis. A photoacoustic (PA) phase-resolved method for noninvasively characterizing the biological tissue viscoelasticity has been proposed by Gao et al. [G. Gao, S. Yang, D. Xing, “Viscoelasticity imaging of biological tissues with phase-resolved photoacoustic measurement,” Opt. Lett. 36, 3341–3343 (2011)]. The mathematical relationship between the PA phase delay and the viscosity–elasticity ratio has been theoretically deduced. Moreover, systems of PA viscoelasticity (PAVE) imaging including PAVE microscopy and PAVE endoscopy were developed, and high-PA-phase contrast images reflecting the tissue viscoelasticity information have been successfully achieved. The PAVE method has been developed in tumor detection, atherosclerosis characterization and related vascular endoscopy. We reviewed the development of the PAVE technique and its applications in biomedical fields. It is believed that PAVE imaging is of great potential in both biomedical applications and clinical studies.