Development and application of numerical model of thermal sensors for thermal protective clothing evaluation based on CFD simulation

PurposeThe purpose of this paper is to study the heat transfer effect of copper sensor and skin simulant on skin.Design/methodology/approachFor the sensor, the physical and mathematical models of the thermal sensors were used to obtain the definite conditions in the heat transfer process of the sensor, and the heat transfer models of the two sensors were developed and solved respectively by using ANSYS WORKBENCH 19.0 software. The simulation results were compared with the experimental test results. For the skin, the numerical model of the skin model was developed and calculated. Finally, the heat transfer simulation performance of the two sensors was analyzed.FindingsIt is concluded that the copper sensor is more stable than the skin simulant, but the material and structure of the skin simulant is more suitable for skin simulation. The skin simulant better simulates the skin heat transfer. For all the factors in the model, the thermal properties of the material and the heat flux level are the key factors. The convective heat transfer coefficient, radiation heat transfer rate and the initial temperature have little influence on the results, which can be ignored.Research limitations/implicationsThe results show that there are still some differences between the experimental and numerical simulation values of the skin simulant. In the future, the thermal parameters of skin simulant and the influence of the thermocouple adhesion should be further examined during the calibration process.Practical implicationsThe results suggest that the skin simulant needs to be further calibrated, especially for the thermal properties. The copper sensor on the flame manikin can be replaced by the skin simulant with higher accuracy, which will be helpful to improve the accuracy of performance evaluation of thermal protective clothing.Social implicationsThe application of computational fluid dynamics (CFD) technology can help to analyze the heat transfer simulation mechanism of thermal sensor, explore the influence of thermal performance of thermal sensor on skin simulation, provide basis for the development of thermal sensor and improve the application system of thermal sensor. Based on the current research status, this paper studies the internal heat transfer of the sensor through the numerical modeling of the copper sensor and skin simulant, so as to analyze the effect of the sensor simulating skin and the reasons for the difference.Originality/valueIn this paper, the sensor itself is numerically modeled and the heat transfer inside the sensor is studied.

Metal-dependent allosteric activation and inhibition on the same molecular scaffold: the copper sensor CopY from Streptococcus pneumoniae

The dynamics and marginal stability of CopY enable allosteric activation of DNA binding by Zn(ii) and inhibition by Cu(i).

Overlap of copper and iron uptake systems in mitochondria in Saccharomyces cerevisiae

In Saccharomyces cerevisiae , the mitochondrial carrier family protein Pic2 imports copper into the matrix. Deletion of PIC2 causes defects in mitochondrial copper uptake and copper-dependent growth phenotypes owing to decreased cytochrome c oxidase activity. However, copper import is not completely eliminated in this mutant, so alternative transport systems must exist. Deletion of MRS3 , a component of the iron import machinery, also causes a copper-dependent growth defect on non-fermentable carbon. Deletion of both PIC2 and MRS3 led to a more severe respiratory growth defect than either individual mutant. In addition, MRS3 expressed from a high copy number vector was able to suppress the oxygen consumption and copper uptake defects of a strain lacking PIC2 . When expressed in Lactococcus lactis , Mrs3 mediated copper and iron import. Finally, a PIC2 and MRS3 double mutant prevented the copper-dependent activation of a heterologously expressed copper sensor in the mitochondrial intermembrane space. Taken together, these data support a role for the iron transporter Mrs3 in copper import into the mitochondrial matrix.