Severe bronchial asthma patient care organization in various regions of the Russian Federation. From endotypes and phenotypes of bronchial asthma to personalized choice of therapy

The meeting of the Expert board was held in Moscow on June 24, 2019, at which the following issues were considered: the applicability of a new terminology characterizing asthma endotypes and phenotypes in real clinical practice, the effect of phenotypes and biomarkers in patients with bronchial asthma on the choice of biological drug, as well as the optimal clinical profiles of patients for whom dupilumab is most effective, taking into account the data of the III phase clinical trials, regional features of medical care and changes in updated international clinical guidelines for the diagnosis and treatment of asthma. The Expert board included members of leading Russian scientific and educational medical institutions: S.N. Avdeev, corresponding member of the Russian Academy of Sciences, prof., MD; O.A. Volkova, Ph.D.; I.V. Demko, prof., MD; G.L. Ignatova, prof., MD; I.V. Leshchenko, prof., MD; Kanukova N.A.; Kudelya L.M., prof., MD; V.A. Nevzorova, prof., MD; N.G. Nedashkovskaya; O.P. Ukhanova, prof., MD; L.V. Shulzhenko, prof., MD; R.S. Fassakhov, prof., MD.

Factors Affecting the Non-Adherence to Inhalational Medication in Bronchial Asthma: A Cross Sectional Study in a Tertiary Care Hospital

Introduction: Modern management of bronchial asthma requires prolonged medications to prevent symptoms and airflow limitations. An important issue in proper management of bronchial asthma is adherence to treatment. Objective: To see the non-adherence rate to inhalational medication in bronchial asthma patient as well as to see the factors responsible for non-adherence. Materials and Method: It was a cross sectional study conducted from 1st September 2017 to 31st March 2018 in Medicine unit of Sir Salimullah Medical College and Hospital (SSMCH). Result: Among the 136 respondents 70% were male and 30% were female. Non adherent rate was 93.7% for male and 100% for female. High cost of medicine, poor counseling, lack of family support, lack of immediate efficacy, forgetfulness, knowledge on how to use device are the main factors for non-adherence. Conclusion: The rate of non-adherence is very high amongst the participants. Therefore promoting optimal medication adherences through education, proper counseling is essential to optimize the benefits of treatment J MEDICINE JAN 2020; 21 (1) : 41-45

Pengaruh Tekhnik Pernafasan Buteyko Terhadap Fungsi Ventilasi Oksigenasi Paru

Patients suffering from asthmadevelop bronchospasm and bronchokontriksi resulting in hyperventilation resulting in decreased ventilation and oxygenation. Interventions to maintain lung oxygenation ventilation function one of them with Buteyko respiratory technique intervention. The purpose of this study was to identify the effect of Buteyko respiratory technique on lung oxygenation ventilation function in bronchial asthma patients. The research design used quasy experiment nonequivalent pre-post control group, and sample number of both groups respectively 15 respondents.The intervention group performed Buteyko breathing technique for 6 weeks.Sampling by consecutive sampling technique. The results of this study indicated that there was a significant difference in pulmonary oxygen ventilation function after Buteyko's breathing technique for 6 weeks (p = 0.00, α = 0.05). The researcher's recommendation is to improve the ventilation function of lung oxygenation by intervening Buteyko respiratory technique in bronchial asthma patient

Calvarial tuberculosis - a case report

Tuberculosis is an infectious disease caused by acid fast bacilli, Mycobacterium tuberculosis that usually affects the lung although it may affect any organ. Tuberculous osteitis of the cranial bone is known as calvarial tuberculosis. The disease is considered secondary to an active or latent tuberculous lesion elsewhere in the body, but direct spread from orbit, paranasal sinuses and face has also been implicated. Though tuberculosis is endemic in Bangladesh, calvarial tuberculosis is very very rare. We report a case of a female, diabetic, hypertensive, chronic kidney disease(CKD), bronchial asthma patient presented with osteolytic lesion in skull with adjacent subcutaneous swelling. She was eventually diagnosed as calvarial tuberculosis on the basis of positive MTB- PCR from the pus aspirated from the swelling.Bangladesh Crit Care J March 2016; 4 (1): 41-43

Long-term results of physiotherapy in treatment of bronchial asthma – case study

Bronchial asthma is a common disease in this day and age, but despite our vast knowledge on it, it still represents a great challenge for contemporary medicine. The paper describes a case of a bronchial asthma patient from the moment of diagnosis until the present day. Based on extensive documentation of multiple stays in sanatoriums, and of outpatient treatment, the paper shows the course of the disease, as well as the applied treatment, rehabilitation and diagnostic tests (spirometry, blood gas test, radiography) that gave grounds for objective assessment of patient’s health and demonstrated the improvement.

Gambaran Jumlah Eosinofil Darah Tepi Penderita Asma Bronkial di Bangsal Paru RSUP Dr. M. Djamil Padang

AbstrakAsma merupakan penyakit gangguan inflamasi kronis saluran pernapasan dengan banyak sel serta elemen seluler yang berperan. Asma dihubungkan dengan hiperresponsif bronkus, keterbatasan aliran udara dan gejala pernapasan yang bersifat reversibel. Salah satu sel yang diketahui berperan besar dalam patogenesis asma adalah eosinofil. Eosinofil melepaskan berbagai mediator seperti Major Basic Protein, Eosinophil Cationic Protein, peroksidase eosinofil, leukotrien C4, serta Platelet-Activating Faktor yang akan merusak epitel saluran napas serta menyebabkan peradangan. Penelitian ini dilaksanakan pada bulan Januari sampai Desember 2012 di Bagian Rekam Medik RSUP Dr. M. Djamil Padang dengan tujuan untuk melihat gambaran jumlah eosinofil darah tepi pada penderita asma bronkial yang dirawat inap. Penelitian yang dilakukan bersifat deskriptif dengan tinjauan retrospektif. Penelitian dilakukan dengan melihat data rekam medis penderita asma bronkial yang dirawat inap di Bangsal Paru RSUP Dr. M. Djamil Padang periode Januari 2010-Desember 2012. Dalam periode dua tahun tersebut, diperoleh 18 sampel yang digunakan pada penelitian ini. Hasil yang diperoleh ialah 4 penderita memiliki jumlah eosinofil darah tepi normal (40-400/mm3) (22,22%) dan 14 penderita memiliki jumlah eosinofil darah tepi dibawah normal (<40/mm3) (77,78%). Tidak ditemukan penderita asma dengan eosinofilia (>400/mm3). Jumlah eosinofil darah tepi pada penderita asma bronkial lebih banyak dibawah normal.Kata kunci: Asma Bronkial, EosinofilAbstractAsthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. Asthma is associated with hyperresponsif bronchi, airflow limitation, and respiratory symptomps that are reversible. One of cells which is known to play a major role in asthma pathogenesis is eosinophil. Eosinophil release a variety of mediators such as Major Basic Protein, Eosinophil Cationic Protein, Eosinophil Peroxidase, Leukotriene C4, and Platelet Activating Factor that will damage airway epithelium and cause inflammation. The research was conducted in January 2012 through December 2012 at Medical Records Department of RSUP Dr. M. Djamil Padang aiming to see the overview of peripheral blood eosinophil number in patient with bronchial asthma who are hospitalized. The research conducted is using descriptive retrospective review. The study is done by looking medical record data of bronchial asthma patient hospitalized in pulmonary ward of RSUP Dr. M. Djamil Padang in the period of January 2010-December 2012. In the two year period, there are 18 patients which are used in the study. The results are 4 patients had normal peripheral blood eosinophil number (40-400/mm3)(22,22%), 14 patients had low peripheral blood eosinophil number (<40/mm3)(77,78%). There is no patient with eosinophilia (>400/mm3). Peripheral blood eosinophil number in bronchial asthma patient is mostly low.Keywords: Bronchial Asthma, Eosinophil