annexin a10
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2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Yosuke Katsuda ◽  
Kenichi Tanaka ◽  
Tomohisa Mori ◽  
Michiko Narita ◽  
Hideyuki Takeshima ◽  
...  

AbstractChronic postsurgical pain (CPSP) is a serious problem. We developed a mouse model of CPSP induced by electrocautery and examined the mechanism of CPSP. In this mouse model, while both incision and electrocautery each produced acute allodynia, persistent allodynia was only observed after electrocautery. Under these conditions, we found that the mRNA levels of Small proline rich protein 1A (Sprr1a) and Annexin A10 (Anxa10), which are the key modulators of neuropathic pain, in the spinal cord were more potently and persistently increased by electrocautery than by incision. Furthermore, these genes were overexpressed almost exclusively in chronic postsurgical pain-activated neurons. This event was associated with decreased levels of tri-methylated histone H3 at Lys27 and increased levels of acetylated histone H3 at Lys27 at their promoter regions. On the other hand, persistent allodynia and overexpression of Sprr1a and Anxa10 after electrocautery were dramatically suppressed by systemic administration of GSK-J4, which is a selective H3K27 demethylase inhibitor. These results suggest that the effects of electrocautery contribute to CPSP along with synaptic plasticity and epigenetic modification.


2021 ◽  
Vol 41 (3) ◽  
pp. 1349-1355
Author(s):  
AKIRA ISHIKAWA ◽  
KAZUYA KURAOKA ◽  
JUNICHI ZAITSU ◽  
AKIHISA SAITO ◽  
TOSHIO KUWAI ◽  
...  

2020 ◽  
Vol 53 (5) ◽  
pp. 113-119
Author(s):  
Akira Ishikawa ◽  
Kazuya Kuraoka ◽  
Junichi Zaitsu ◽  
Akihisa Saito ◽  
Toshio Kuwai ◽  
...  

2020 ◽  
Vol 26 (4) ◽  
pp. 2509-2521
Author(s):  
Benjamin Marquet ◽  
Aude Marchal Bressenot ◽  
Caroline Fichel ◽  
Nicole Bouland ◽  
Coralie Barbe ◽  
...  

2020 ◽  
Vol 526 (3) ◽  
pp. 692-698
Author(s):  
Hirosato Mashima ◽  
Kenichi Takahashi ◽  
Masanari Sekine ◽  
Satohiro Matsumoto ◽  
Takeharu Asano ◽  
...  

Author(s):  
Akira Ishikawa ◽  
Naoya Sakamoto ◽  
Ririno Honma ◽  
Daiki Taniyama ◽  
Kaho Fukada ◽  
...  

2019 ◽  
Vol 25 ◽  
pp. 5666-5673 ◽  
Author(s):  
Jing Wang ◽  
Shanshan Zhao ◽  
Fangfang Wang ◽  
Jing Wang ◽  
Yuhua Zhang

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
LiHong Sun ◽  
Qi Xu ◽  
WenXin Zhang ◽  
CuiCui Jiao ◽  
Hui Wu ◽  
...  
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