Validated RP-HPLC Method for the Estimation of Amiloride and Hydrochlorothiazide in Combined Tablet Dosage Form

The aim of this work is to build up a rapid, exact, precise and accurate reverse phase liquid chromatographic method for the simultaneous analysis of amiloride and hydrochlorothiazide in tablet dose structure. The chromatographic strategy was normalized utilizing Hypersil ODS coulmn (250×4.6mm, 5μm molecule size) with UV detection at 210nm and flow rate of 1ml/min. The mobile phase includes phosphate buffer (pH acclimated to 2.5 with dilute Ortho Phosphoric acid) and acetonitrile in the proportion of 60:40 v/v. The linearity of proposed technique was found in the range of 5-30μg/ml (R²=0.999) for amiloride and 50-300μg/ml (R²=0.999) for Hydrochlorothiazide appropriately. The limit of detection (LOD) was discovered to be 0.10μg/ml and 0.40μg/ml for Amiloride and Hydrochlorothiazide appropriately. The limit of quantitation (LOQ) was discovered to be 0.30μg/ml and 1.20μg/ml for Amiloride and Hydrochlorothiazide separately. The retention times of Amiloride and Hydrochlorothiazide were found to be 3.258min and 2.383min separately. The technique was truly recommended and %RSD was found to be under 2 demonstrating high degree of exactness and accuracy. Subsequently proposed strategy can be effectively evaluated for the simultaneous estimation of Amiloride and Hydrochlorothiazide in promoted formulations.

Cheney–Sharma type operators on a triangle with two and three curved edges

UDC 517.5 We construct some Cheney–Sharma type operators de ned on a triangle with two and three curved edges, their product and Boolean sum. We study their interpolation properties and the degree of exactness.

Quadratic quadrature formula for curves with third degree of exactness

In this article, a quadrature formula of degree 2 is given that has degree of exactness 3 and order 5. The formula is valid for any planar curve given in parametric form unlike existing Gaussian quadrature formulas that are valid only for functions.

Interpolation Operators on a Triangle With all Curved Sides

This paper contains a survey regarding interpolation and Cheney-Sharma type operators defined on a triangle with all curved sides; we considers as well some of the product and Boolean sum operators. We study their interpolation properties and the degree of exactness

Quadrature rules with an even number of multiple nodes and a maximal trigonometric degree of exactness

This paper is devoted to the interpolatory quadrature rules with an even number of multiple nodes, which have the maximal trigonometric degree of exactness. For constructing of such quadrature rules we introduce and consider the so-called s- and ?-orthogonal trigonometric polynomials. We present a numerical method for construction of mentioned quadrature rules. Some numerical examples are also included.

Interpolation operators on a triangle with two and three curved edges

We construct Lagrange, Hermite and Birkhoff-type operators, which interpolate a given function and some of its derivatives on the border of a triangle with two and three curved edges. We also consider some of their product and boolean sum operators. We study the interpolation properties and the degree of exactness of the constructed operators.