Fluid-Structure Interaction Simulations of Parachute Deployment and Inflation

The numerical simulation of the parachute deployment/inflation process involves fluid structure interaction problems, the inherent complexities in the fluid structure interaction have been posing several computational challenges. In this paper a high fidelity Eulerian computational approach is proposed for the simulation of parachute deployment/inflation. Unlike the arbitrary Eulerian Lagrangian (ALE) method widely employed in this area, the Eulerian computational approach is established on three computational techniques: computational fluid dynamics, computational structure dynamics and computational moving boundary. A set of stationary, non-deforming Cartesian grids is adopted in our computational fluid dynamics, our computational structure dynamics is enhanced by non-linear finite element method and membrane wrinkling algorithm, instead of conventional computational mesh dynamics, an immersed boundary method is employed to avoid insurmountable poor grid quality brought in by moving mesh approaches. To validate the proposed numerical approach the deployment/inflation of C-9 parachute is simulated using our approach and the results show similar characteristics compared with experimental results and previous literature. The computed results have demonstrated the proposed method to be a useful tool for analyzing dynamic parachute deployment and subsequent inflation.

Ocular findings in patients with transfusion-dependent β-thalassemia in southern Iran

Background Ocular involvement may occur via several mechanisms in patients with transfusion-dependent β-thalassemia (TDT) mainly chronic anemia, iron overload and iron chelator toxicity. We aimed to evaluate the frequency of abnormal ocular findings and their relationship with hematologic parameters in TDT patients. Methods In this cross-sectional study from January 2018 to January 2019, a total of 79 patients with TDT over the age of 18 who were on iron-chelation therapy (ICT) were consecutively investigated. All patients were registered at the Thalassemia Comprehensive Center affiliated with Shiraz University of Medical Sciences, Shiraz, Southern Iran. Complete ophthalmic examination was performed by an expert ophthalmologist. Clinical and hematologic parameters were collected from the patients´ medical records. Results The mean age ± standard deviation (SD) of the patients was 28.4 ± 5.6 years (range: 18–43). Twenty-four patients (30.4%) were male and 29 (36.7%) were splenectomized. The mean ± SD of the best-corrected visual acuity (VA) was 0.960 ± 0.086 decimal, (range: 0.6–1), 0.016 ± 0.046 logMar, (range: 0–0.2). The frequency of patients with VA > 0.1 logMar was 3 (3.8%). The mean intraocular pressure (IOP) was 14.88 ± 3.34 (6–25) mmHg. Fundus abnormalities were observed in 8 patients (10.1%), consisting of increased cup-disk ratio (3.8%), vessel tortuosity (2.5%), retinal pigment epithelium degeneration (2.5%), myelinated nerve fiber layer (1.3%), and internal limiting membrane wrinkling (1.3%). No significant association was observed between fundus abnormalities, VA, or IOP with hematologic parameters (P > 0.05). TDT patients with diabetes mellitus had significantly higher IOP (P = 0.010) but similar frequency of fundus abnormalities with non-diabetic patients (P > 0.05). Conclusions The frequency of ocular abnormalities in our patients was lower than the previous reports. The frequency of fundus abnormalities were similar in diabetic and non-diabetic thalassemia patients indicating close monitoring and proper management of the disease and comorbidities in these patients.