Treatment of Hepatitis C with Glecaprevir/Pibrentasvir in a Patient with Concurrent Stricturing Crohn’s Disease on Adalimumab

A 22-year-old male with long standing, active Crohn’s disease on Adalimumab had presented with increasing levels of his transaminases. A full workup was conducted and the patient was found to have hepatitis C (HCV) based on a positive HCV antibody, polymerase chain reaction (PCR) and genotyping. He was started on a regimen of Glecaprevir/Pibrentasvir with excellent response defined by complete normalization of his transaminitis and an undetectable PCR at the end of 8 weeks of treatment and achieved sustained viral response at 12 weeks of treatment. This is the first case reporting the use of a combination of Glecaprevir/Pibrentasvir and Adalimumab in a patient with HCV and Crohn’s disease. Key words: Hepatitis C, Glecaprevir/Pibrentasvir, Crohn’s Disease

TREATMENT OF CHRONIC HEPATITIS C GENOTYPE 6 PATIENT WITH TRIPLE THERAPY PEG-IFN, RIBAVIRIN AND SOFOSBUVIR: CASE REPORT AND REVIEW OF LITERATURE

The author presents a case with chronic hepatitis C, genotype 6, treated with triple regime: Peg-IFN combined to ribavirin and sofosbuvir. After 3 months of therapy and 3 months follow up, patient has good clinical and virological response (SVR 12). Some results of similar studies in Vietnam and abroad, especially the studies concerning the new agents DAAs were also presented, analysed and compared with author’s results. Key words: Hepatitis C, treatment, Peg-IFN, Ribavirin, Sofosbuvir

Risk factors for hepatitis C disease in Tando Allahyar, Pakistan: a case-control study

Objective: Present study was undertaken to explore the epidemiological and dietary risk factors for hepatitis C disease in Tando Allahyar during June to December 2007. Materials and methods: 140 Hepatitis C patients and 149 controls (age, sex and locality matched with no personal or family history of hepatitis C) were randomly selected from the Tando Allahyar population during June 2007 to December 2007. A standard questionnaire specially developed for that purpose, was distributed among patients and controls. Accurate rapid card test was performed to confirm Hepatitis C virus (HCV) positive or negative patients and controls. O.R with 95% confidence interval was computed and p values were calculated by chi square test. Results: Over all findings showed that among 140 HCV patients 64% were females and 36% males (mean age range was 20-48 years). Our results showed strong positive association of sedentary life style (OR=4, 95% CI, 1.48-10.6, p=0.005), marital status, +ve family history, B+ve blood group, piercing, syringe use (70%), multiple pregnancies (OR=4.72, 95% CI, 1.47-15.15, p=0.008), blood transfusion (OR=4.4, 95% CI, 1.2-14.95, p=0.017), take out food debris by office pins (NS), shave at barber’s shop (NS), dental procedures (NS), medicines used in past (OR=3.08, 95% CI, 1.2-7.71, P=0.016), G.I.T diseases (OR =8.66, 95% CI, 1.28-55.58, p=0.023), stones of kidney or gallbladder, jaundice, Tuberculosis and psychological problems (OR =2.5, 95% CI, 1.04-6.13, P=0.04) with hepatitis C disease. We did not find any association of surgery, BMI, ENT, diseases, meat consumption and smoking with the disease. Vegetables OR =0.842, 95% CI, 0.361-1.964, P=0.694), pulses, tomatoes (OR =0.31, 95% CI, 0.041-2.53, P=0.31), and tea (OR =0.598, 95% CI, 0.251-1.431, P=0.25) were found to be the protective factors for Hepatitis C disease. Conclusion: Sedentary life style, multiple pregnancies, blood transfusion, medicines used in past, G.I.T diseases, and psychological problems are significantly positively associated with Hepatitis C disease. Key words: Hepatitis C disease, HCV infection, epidemiological risk factors, Diet, blood transfusion, G.I.T diseases, and psychological problems. DOI: http://dx.doi.org/ 10.3329/bjms.v10i3.8359 BJMS 2011; 10(3): 163-169

Seroprevalence of Hepatitis C Virus among Health Care Workers

Context: Hepatitis C virus is one of the leading causes of liver disease and represents a major public health problem. It is a common cause of cirrhosis and hepatocellular carcinoma (HCC) as well as the most common reason for liver transplantation. Methods: A cross sectional study was carried out during the period of April 2007 to April 2008 among health care workers including phlebotomists, dialysis staffs and laboratory personnel handling blood and blood products. Total 200 health care workers from phlebotomists working at one stop collection centre of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka Medical College Hospital (DMCH), Dialysis staff working at haemodialysis units of BSMMU, Bangladesh Institute of Rehabilitation for Diabetes, Endocrine & Metabolic Diseases (BIRDEM), DMCH, National Institute of Kidney Diseases & Urology (NIKDU) had at least more than one year working exposure was enrolled in this study. After taking informed written consent detailed history was taken, clinical examination was done. 0.3 ml of venous blood was collected from each patient and tested for anti HCV by commercial kit, confirmed by ELISA method. Result: Among 200 patients majority (55.5%) of patients were below 30 years of age and there was equal prevalence among male and female. Out of 200 health care workers 1% was found to be anti HCV positive. All positive patient had duration of exposure of >5 years and had history of needle stick injury. Key words: Hepatitis C virus; seroprevalence; health care workers. DOI: 10.3329/jdmc.v18i1.6310 J Dhaka Med Coll. 2009; 18(1) : 70-74