Integrated Design of Process-Tolerance for Remanufacturing Based on Failure Feature

The uncertainty failure of the used part leads the complexity selection of remanufacturing processes. The different remanufacturing process combinations among used parts of used products also make the formulation of tolerance schemes more difficult. It is hard to guarantee the optimality of process-tolerance schemes by traditional serial production modes in general, in which tolerance design is followed by process formulation. In order to generate the optimal remanufacturing scheme of process and tolerance for used products, an optimization method to integrate designs of process-tolerance (IDP-T) based on fault features was presented. In this work, the failure description set of used parts was constructed by combining the attribute characteristics and failure characteristics. Case-based reasoning (CBR) was first utilized to generate the feasible remanufacturing process plans of used parts. Then, based on the feasible process plans, the factors of cost, quality loss, closed-loop accuracy and machining ability of remanufacturing were comprehensively considered to construct the optimization model of IDP-T. The Beetle Antennae Search algorithm (BAS) was used for the optimal alternative selection. Finally, a used gearbox was taken as an example to illustrate the validity and practicality of the proposed method. The results showed that the proposed method was effective in the optimization of IDP-T for remanufacturing.

Diffraction mechanism of five-port transmission gratings

This paper designs a five-port transmission grating under normal incidence. Rigorous coupled-wave approach is used to optimize the grating parameters. The energy of the grating is mainly dispersed to the 0th, ±1st and ±2nd orders. The efficiency of each diffraction order under both polarizations is close to 20%. The modal method is used to describe the propagation mechanism of the two polarized lights in the grating, and the diffraction behavior of the grating is analyzed. In addition, the grating has a wide range of incident characteristics and a large process tolerance. Therefore, this five-port beam splitter with a connecting layer will be a good polarization-independent beam splitting device.

Formation of 1 × 3 splitting by embedded double-layer reflective grating under second Bragg illumination

In order to obtain a [Formula: see text] grating with high performance, we designed a double-layer reflective grating beam splitter with a covering layer at a wavelength of 1550 nm. We obtain a better grating structure by modal analysis and rigorous coupled-wave method. The reflectivity of the three diffraction orders for the grating is close to 33.3%. The optimized data show that the grating beam splitter has a large period process tolerance for TE polarization. The grating performance has high incident performance and uniform splitting effect.

PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancer

Background Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibody therapy. This study aimed to identify PD-1/PD-L1 correlated genes and pathways as well as investigate their potential as prognostic marker in BC. Materials and methods By analysing transcriptional data of BC from TCGA, we identified PD-1 and PD-L1 correlated genes by WGCNA analysis and explored the biological process as well as pathways they enriched. Co-expression analysis were performed for PD-1/PD-L1 with immune infiltration and checkpoints. The prognostic value of PD-1 and PD-L1 were also investigated. Results PD-1 and PD-L1 expression showed significant difference in different molecular subtypes and stages. PD-1 correlated genes enriched in T cell activation, lymphocyte activation, leukocyte migration while PD-L1 correlated genes demonstrated enrichment including T cell apoptotic process, tolerance induction and cytolysis. Immune infiltration analysis suggested that PD-1 and PD-L1 were related with Neutrophils (r = 0.65, r = 0.48) and Fibroblasts (r = 0.59, r = 0.47). For immune checkpoints analysis, PD-1 was associated with HLA-A (r = 0.804) and INPP5D (r = 0.782) while PD-L1 correlated with CTLA4 (r = 0.843) and CD27 (r = 0.823). PD-1 was associated favorable survival of BC (HR = 0.67, P = 0.012) while PD-L1 did not demonstrate significant association with BC prognosis (HR = 0.85, P = 0.313). Conclusion PD-1 and PD-L1 correlated genes participated in biological process including T cell activation, lymphocyte activation, leukocyte migration, T cell apoptotic process, tolerance induction and cytolysis. PD-1/PD-L1 expression also demonstrated relation with immune infiltration and immune checkpoints. High PD-1 expression predicted better survival of breast cancer patients.