Jaccoud’s Arthropathy in Gout: An Unusual Association

Jaccoud’s arthropathy (JA) is a deforming arthropathy observed mainly in patients with systemic lupus erythematosus. We report the case of a 41-year-old Brazilian man with a 10-year history of intermittent monoarthritis followed by bouts of polyarthritis affecting large and small joints. He presented deformities typical of JA and subcutaneous nodules. Histopathological findings of a nodule biopsy were consistent with gouty tophi. To our knowledge, this is the first report of JA secondary to chronic gout.

Ochronosis

• Metabolic disorder of deforming arthropathy • Homogentisic acid in urine, which becomes dark on standing and is characteristic • May be first diagnosed on lateral CXR • Eventually pigmentation of skin, sclerae, and ear and nose cartilage • Earliest change is laminated calcification of intervertebral disk, followed by collapse of disk spaces and osteoporosis. Osteophytes are a later occurrence, as is involvement of weight-bearing joints...

Bone Fracture With Cushing Disease

• See next slide • Metabolic disorder of deforming arthropathy • Homogentisic acid in urine, which becomes dark on standing and is characteristic...