High-Frequency Three-Dimensional Lumen Volume Ultrasound Is a Sensitive Method to Detect Early Aneurysmal Change in Elastase-Induced Murine Abdominal Aortic Aneurysm

Objective The aim of this study was to investigate the reproducibility of anterior–posterior diameter (APdmax) and three-dimensional lumen volume (3DLV) measurements of abdominal aortic aneurysms (AAA) in a classical murine AAA model. We also compared the magnitude of change in the aortic size detected with each method of assessment. Methods Periadventitial application of porcine pancreatic elastase (PPE AAA) or sham surgery was performed in two cohorts of mice. Cohort 1 was used to assess for observer variability with the APdmax and 3DLV measurements. Cohort 2 highlighted the relationship between APdmax and 3DLV and changes in AAA detected. Results There was no significant observer variability detected with APdmax measurement. Similarly, no significant intraobserver variability was evident with 3DLV; however, a small but significant interobserver difference was present. APdmax and 3DLV measurements of PPE AAA significantly correlated. However, changes in the AAA morphology were detected earlier with 3DLV. Conclusion APdmax and 3DLV are both reliable methods for measuring an AAA. Both these methods correlate with each other. However, changes in AAA morphology were detected earlier with 3DLV, which is important to detect subtle but important changes to aortic geometry in a laboratory setting. 3DLV measurement of AAA is a simple, reproducible, and comprehensive method for assessing changes in disease morphology.

Right lobo-isthmic agenesis of the thyroid: A case report

The authors report the observation of a 36-year-old woman with right lobo-isthmic agenesis complicated by an adenoma developed at the expense of the left lobe. The patient presented for many years a presumed cystic nodule developed at the expense of the left lobe, having recently increased in volume. Ultrasound and scannographic studies suggested that the right lobe and isthmus were absent. At cervicotomy, it was a hypoplasia of the right lobe and isthmus. Keywords: Congenital Anomaly; Thyroid; Lobar Agenesis; Clinical Case

Assessment of fetal ribs at first trimester of gestation

Experience of prenatal volume ultrasound diagnosis of ribs anomalies at first trimester of gestation is presented.