Successful Chemotherapy of an Acute Myeloid Leukemia Case Infected with SARS-CoV-2

Introduction: New coronavirus or severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in Wuhan, China at the end of 2019. There is not enough data for managing acute myeloid leukemia patients with concomitant infection with SARS-COV-2. This is a report of a unique case with acute leukemia and SARS-CoV-2 infection that recovered from both. Case Presentation: a 44-year man was admitted with fever and sweating. He was treated with broad-spectrum antibiotics. Pancytopenia was detected and a bone marrow biopsy revealed acute leukemia. During his management, the patient developed a dry cough. He was transferred to our center for chemotherapy. Chest CT scan revealed bilateral peripheral patchy ground-glass infiltrations, indicating SARS-CoV-2 infection. Two weeks later, after antiviral and broad-spectrum antibiotic therapy, he developed severe dyspnea and became bedridden. Modified chemotherapy was started. He was rapidly recovered and developed complete remission. Conclusions: Immune system response to SARS-CoV-2 is under investigation. Cytokine storm was postulated for acute respiratory distress syndrome in these patients. Severe dyspnea in our patient may be due to cytokine storms and some degrees of leukostasis. We presented a successful chemotherapy of an acute leukemia patient that was simultaneously infected with COVID-19.

Genome Sequence of Staphylococcus aureus Strain CBS2016-05, Isolated from Contaminated Platelet Concentrates in Canada

We present the genome sequence of Staphylococcus aureus strain CBS2016-05, which was isolated from contaminated platelet concentrates by Canadian Blood Services in 2016. This strain caused a septic reaction in an acute leukemia patient. Genome sequence analysis revealed the presence of one chromosome (2,766,936 bp) and one plasmid (36,441 bp).

Fusarium Endophthalmitis, Unusual and Challenging Infection in an Acute Leukemia Patient

Invasive fungal infections bring serious mortality and morbidity during the treatment of acute myeloid leukemia. Especially, mold infections are challenging, and each case is unique in feature. These cases are usually fatal, and there is no consensus regarding optimal treatment. AML patients receive antifungal prophylaxis and may further require IFI (invasive fungal infection) treatments, but fusarium mold infections are often unrecognized and could be overlooked. In this case report, we try to emphasize the importance of this infection with a high-risk AML patient.